Champions League Best Bets for Wednesday, September 17: Picks & Predictions
The action in the first week of the 2025/26 UEFA Champions League continues Wednesday with six more matches after an action-packed six-game slate from Tuesday. Here are my three best bets for Wednesday's slate.
UEFA Champions League SGP for Inter Milan at Ajax
Both teams to score and over 2.5 total goals -103
Ajax are one of the top title contenders in the Eredivisie and have enjoyed a solid start after going undefeated in their first five league matches (W3, D2). However, it's unclear if that strong domestic start will translate to European success, especially when facing opponents such as Inter Milan.
The Nerazzurri are in dire need of a bounce-back performance since they have lost their previous two Serie A matches, including a classic against Juventus by a 4-3 score the last time out.
On paper, all signs point to this game being a back-and-forth match. Inter have the edge in terms of personnel and individual talent, but their defensive problems have been noticeable over their last two league matches. Ajax have endured a fair share of woes at the back, as well, routinely conceding against lesser rivals, so it's unclear if they'll have enough quality to contain an Inter side that scored three goals against Juventus only a few days ago.
With far more talent in the attacking third than at the back for both clubs, it's fair to envision a scenario with both sides scoring and over two goals on Dutch soil.
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UEFA Champions League Best Bets for Chelsea at Bayern Munich
Luis Diaz anytime goalscorer +160
Bayern Munich have been one of the most dominant teams in Europe in the early stages of the season and have won their five competitive matches while scoring at least three goals in all but one. With impressive results such as the 6-0 win over RB Leipzig and the 5-0 thrashing of Hamburger SV, it's hard to see most teams in Europe trying to slow down Bayern's potent attack. The trio of Luis Diaz, Michael Olise and Harry Kane is going to create nightmare matchups for every defensive line they face.
Diaz knows a thing or two about scoring against Chelsea, as the Colombian found the back of the net in his last two starts against the Blues when he was playing for Liverpool. Kane will be the focal point of Bayern's attack, but Diaz has enjoyed an excellent start to the campaign with four goals and two assists in five appearances across all competitions.
Diaz seems to have rediscovered his best form with the move to Bayern, and it wouldn't be surprising if he extends his impressive debut campaign with Die Roten with a goal against a former Premier League opponent.
Atletico Madrid at Liverpool Betting Odds & Best Bet
Liverpool to win at HT/FT +125
Liverpool have enjoyed a perfect start to the Premier League season and have looked better with each passing game. After a couple of subpar defensive performances in the wins over Bournemouth and Newcastle United, Arne Slot's men have recorded back-to-back clean sheets against Arsenal and Burnley.
The Reds should be motivated to extend their impressive run of play against an Atletico Madrid side that has underperformed to start the campaign. With only one win in their first four LaLiga matches, Diego Simeone's men are far from their best version, which shouldn't be a recipe for success ahead of a tough trip to Anfield.
Liverpool will have Alexander Isak available to make his club debut Wednesday after missing the win over Burnley, and integrating the Swede will give Slot another elite attacking weapon to slot alongside Mohamed Salah, Florian Wirtz, Cody Gakpo and Hugo Ekitike.
Atletico will be shorthanded for this trip to Anfield, with Julian Alvarez (knee), Johnny Cardoso (ankle), Thiago Almada (leg), Jose Maria Gimenez (strain) and Alex Baena (strain) all sidelined. The lack of depth will be too much to overcome for Los Colchoneros, and Liverpool should be able to control the game right from the start. Expect Slot's men to win this game with ease, establishing the lead in HT and cruising to a FT victory.
Champions League Betting Picks Wednesday, September 17
- Both teams to score and over 2.5 total goals in Ajax vs. Inter Milan -103
- Luis Diaz to score anytime for Bayern Munich +160
- Liverpool to win at HT/FT +125
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