This article is part of our NFL Picks series.
No write ups again for this week, but we'll have a special holiday write up for Week 17 relatively early in the week so that everyone can take advantage of the betting action throughout the multitude of NFL days to come.
Below you'll find my picks against the spread and on the totals for each game on the Week 16 NFL slate. For more NFL betting content here at RotoWire, check out our NFL picks series with several articles dropping each week.
NFL Week 16 Betting Picks For Each Game
| Date | Game Matchup | Week 16 Picks |
| Thursday, December 19 | Broncos vs. Chargers | Broncos +2.5, under 41.5 |
| Saturday, December 21 | Texans vs. Chiefs | Chiefs -3.5, over 42.5 |
| Saturday, December 21 | Steelers vs. Ravens | Ravens -6.5, over 45 |
| Sunday, December 22 | Browns vs. Bengals | Bengals -8.5, over 46.5 |
| Sunday, December 22 | Giants vs. Falcons | Giants +8.5, under 42 |
| Sunday, December 22 | Cardinals vs. Panthers | Panthers +5, under 47 |
| Sunday, December 22 | Lions vs. Bears | Lions -6.5, over 48 |
| Sunday, December 22 | Titans vs. Colts | Colts -3.5, over 42.5 |
| Sunday, December 22 | Rams vs. Jets | Rams -3, under 46.5 |
| Sunday, December 22 | Eagles vs. Commanders | Eagles -3.5, over 45.5 |
| Sunday, December 22 | Vikings vs. Seahawks | Vikings -3, over 42.5 |
| Sunday, December 22 | Patriots vs. Bills | Patriots +14, over 46.5 |
| Sunday, December 22 | Jaguars vs. Raiders | Jaguars +1.5, under 40.5 |
| Sunday, December 22 | 49ers vs. Dolphins | 49ers -1, over 44.5 |
| Sunday, December 22 | Buccaneers vs. Cowboys | Buccaneers -4, over 48 |
| Monday, December 23 | Saints vs. Packers | Packers -14, over 42.5 |
Week 15 Record ATS: 12-4
Week 15 Record on Totals: 7-9
Season Record ATS: 125-99-3
Season Record on Totals: 110-112-1
NFL Week 16 Best Bets
Next, we take a look at our favorite Week 16 NFL best bets at the best NFL betting sites. For the first time doing this series, I hit on a perfect 8-0 among my best bets including a handful of plus-money parlays. While I'm obligated to pick against the spread above, the best bets section highlights my favorite leans and also tries to take advantage of a few of the parlay props offered as of this writing.
BetMGM Best Bets for NFL Week 16
BetMGM offers some of the best odds available for Week 16. If you're not signed up at BetMGM yet, new players at BetMGM can use the BetMGM bonus code ROTOBONUS for a risk-free bet worth up to $1,000. Here are our NFL best bets for Week 3 at BetMGM.
- Brenton Strange over 35.5 receiving yards (-130)
- (+350) DAL/TB three-item SGP -- Mike Evans over 71.5 receiving yards, Ceedee Lamb over 73.5 receiving yards and Buccaneers moneyline
Caesars Sportsbook Best Bets for NFL Week 16
Caesars Sportsbook also has great betting odds for NFL Week 16. If you are not registered yet, use the Caesars Sportsbook promo code ROTOFULL for a first bet on Caesars.
- Two-item parlay (+149) -- Colts and Vikings moneyline
- 49ers pick-em (-110)
DraftKings Best Bets for NFL Week 16
DraftKings Sportsbook has special offers for new users just in time for Week 16 of the NFL season. here are our best picks available at DraftKings Sportsbook this week.
- (+248) Three-item parlay -- Kyren Williams, Derrick Henry and James Conner all for anytime touchdown
FanDuel Best Bets for NFL Week 16
One of the most popular sportsbooks available is FanDuel Sportsbook. Let's take a look at our favorite betting picks with FanDuel odds.
- Rams -3 (-105)
- Jaguars moneyline (+106)
BetRivers Best Bets for NFL Week 16
BetRivers is an up-and-coming and underrated sportsbook, and they are offering up to $500 in second-chance bets with the BetRivers bonus code. Bettors can use those for these picks on NFL Week 16.
- Ravens -6 (-109)
Fanatics Sportsbook Best Bets for NFL Week 16
Fanatics Sportsbook is ringing in its first full NFL season. You can get in on the action at Fanatics by using the Fanatics Sportsbook promo for up to $1,000 in bonus bets over the first 10 days that your account is active. Here are our favorite picks this week using odds at Fanatics Sportsbook.
- Buccaneers -4.5 (-110)
Look ahead at the NFL Week 17 odds as well, if you're interested in getting ahead of the line movement.
