The Latest 49ers Odds For NFL Season 2025
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San Francisco 49ers
0-0 (0-0 in the NFC West)
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49ers Week 1 Matchup
Sunday at 4:05 pm EST
San Francisco 49ers
23.5 Pts
23.5 Pts
@
Seattle Seahawks
22.0 Pts
22.0 Pts
Moneyline
DraftKings Spread
DraftKings Over Under
DraftKings PROBABILITY with vig removed
49ers Win (-122)
52.6%
Seahawks Win (+102)
47.4%
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Projected Record: 11-6 (3-3 NFC West)
Win Totals
DraftKings Wins
PROBABILITY with vig removed
Over 10.5 Wins(110)
45.7%
Under 10.5 Wins(-130)
54.3%
LINE MOVEMENT
No changes have been recorded yet.
No changes have been recorded yet.
No changes have been recorded yet.
Super Bowl
DraftKings LINE MOVEMENT
NFC Champ
DraftKings LINE MOVEMENT
NFC West
DraftKings LINE MOVEMENT
49ers Injury Report
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49ers News
S
George Odum: Sidelined entering 2025
Jul 18th
Odum (knee) was placed on the active/non-football injury list Friday.
OG
Ben Bartch: Out to begin camp
Jul 18th
Bartch (undisclosed) was placed on the active/non-football injury list Friday.
LB
Curtis Robinson: Not healthy to open camp
Jul 18th
Robinson (undisclosed) was placed on the active/PUP list Friday.
DE
Yetur Gross-Matos: Sidelined to begin training camp
Jul 18th
Gross-Matos (undisclosed) was placed on the active/PUP list Friday.
OT
Andre Dillard: Lands on PUP
Jul 18th
Dillard (undisclosed) was placed on the active/PUP list Friday.
49ers Depth Chart
Quarterback QB
Running Back RB
Wide Receiver WR
Fullback FB