San Francisco 49ers vs Seattle Seahawks Odds, Week 18, 2025

#1 WR

Jauan Jennings: Disappointing Week 18 performance

Jan 3rd

Jennings recorded four receptions on six targets for 35 yards in Saturday's 13-3 loss to the Seahawks.

#1 TE

George Kittle: One long catch

Jan 3rd

Kittle recorded five receptions on seven targets for 29 yards in Saturday's 13-3 loss to the Seahawks.

#1 QB

Brock Purdy: Struggles against Seahawks

Jan 3rd

Purdy completed 19 of 27 passes for 127 yards, no touchdowns and one interception in Saturday's 13-3 loss to the Seahawks.

#1 RB

Christian McCaffrey: Stifled by Seattle

Jan 3rd

McCaffrey rushed the ball eight times for 23 yards in Saturday's 13-3 loss to the Seahawks. He added six receptions on seven targets for 34 yards.

#3 MLB

Tatum Bethune: Dealing with groin issue

Jan 3rd

Bethune is questionable to return to Saturday's game against the Seahawks due to a groin injury, Nick Wagoner of ESPN.com reports.

#1 WLB

Dee Winters: Questionable to return in Week 18

Jan 3rd

Winters suffered an ankle injury in Saturday's game against the Seahawks and is questionable to return.

#1 LT

Trent Williams: Inactive for Saturday night

Jan 3rd

Williams (hamstring) is inactive for Saturday night's game against the Seahawks, Briana Jeannel of the 49ers' official site reports.

#3 LDE

Keion White: Active for Saturday night

Jan 3rd

White (groin) is active for Saturday night's game against the Seahawks, Briana Jeannel of the 49ers' official site reports.

#2 WLB

Curtis Robinson: Healthy scratch again

Jan 3rd

Robinson (coach's decision) is inactive for Saturday night's game against the Seahawks, Briana Jeannel of the 49ers' official site reports.

#4 WR

Kendrick Bourne: Stands to benefit with Pearsall out

Jan 3rd

Bourne is in line for more work Saturday versus the Seahawks due to Ricky Pearsall (knee/ankle) being inactive, Brianna Jeannel of the 49ers' official site reports.

#1 SCB

Upton Stout: Active for Week 18

Jan 3rd

Stout (concussion) is active for Saturday night's game against the Seahawks, Briana Jeannel of the 49ers' official site reports.

#2 WR

Ricky Pearsall: Inactive Saturday

Jan 3rd

Pearsall (knee/ankle) is inactive for Saturday's game against the Seahawks, Briana Jeannel of the 49ers' official site reports.

#2 LDE

Yetur Gross-Matos: Good to go for Week 18

Jan 1st

Gross-Matos (knee) will not carry an injury designation into Saturday's contest against the Seahawks.

#1 FB

Kyle Juszczyk: Good to go for Saturday

Jan 1st

Juszczyk (hip) does not have an injury designation for Saturday's matchup versus Seattle.

#3 RB

Jordan James: No run on offense in Week 17

Dec 31st

James played just two snaps -- both on special teams -- in Sunday's 42-38 win over the Bears.

#5 WR

Skyy Moore: Notches first down on rush

Dec 31st

Moore carried once for 10 yards and brought back two punts for 11 yards and four kickoffs for 92 yards in Sunday's 42-38 win over the Bears.

#8 WR

Jacob Cowing: Practice window could open soon

Dec 31st

San Francisco head coach Kyle Shanahan said Friday that Cowing (hamstring) could have his 21-day practice window opened during Week 18 prep, Matt Barrows of The Athletic reports.

#1 LCB

Renardo Green: No limitations Tuesday

Dec 30th

Green (neck) is expected to be listed as a full participant at practice Tuesday, Nick Wagoner of ESPN.com reports.

#1 FS

Malik Mustapha: Tallies three tackles vs. Chicago

Dec 29th

Mustapha registered three tackles (two solo) and one pass defense during San Francisco's 42-38 win over Chicago on Sunday.

#1 SS

Ji'Ayir Brown: Tallies four stops in Week 17 win

Dec 29th

Brown registered four tackles (one solo) and one pass defense during the 49ers' 42-38 win over the Bears on Sunday.

#3 QB

Kurtis Rourke: Officially out for 2025

Dec 29th

Rourke (knee) will remain on the 49ers' reserve/non-football injury list for the rest of the 2025 season, Matt Maiocco of NBC Sports Bay Area reports.

#3 TE

Luke Farrell: No targets sans Kittle in Week 17

Dec 29th

Farrell logged 27 snaps on offense and wasn't targeted in Sunday's 42-38 win over the Bears.

#3 WR

Demarcus Robinson: Grabs two receptions Sunday

Dec 29th

Robinson caught both of his targets for 30 yards in Sunday's 42-38 win over the Bears.

#2 RB

Brian Robinson: Garners five touches Sunday

Dec 29th

Robinson took four carries for 22 yards and grabbed his only target for six yards in Sunday's 42-38 win over Chicago.

#2 TE

Jake Tonges: Cashes in on prime opportunity

Dec 28th

Tonges corralled seven of nine targets for 60 yards and a touchdown in Sunday's 42-38 win over the Bears.

#1 K

Eddy Pineiro: Makes all six PATs in win

Dec 28th

Pineiro didn't attempt a field goal in Sunday's 42-38 win over the Bears but converted all six of his extra-point tries.

#4 RB

Isaac Guerendo: Healthy scratch again in Week 17

Dec 28th

Guerendo (coach's decision) is inactive for Sunday's game against Chicago.

#6 WR

Jordan Watkins: Inactive in Week 17

Dec 28th

Watkins (coach's decision) is inactive for Sunday's game against the Bears.

#2 MLB

Fred Warner: Could return during playoffs

Dec 27th

Warner (ankle) is ahead of schedule in his recovery and could be a candidate to return to action if the 49ers make a deep playoff run, Ian Rapoport and Mike Garafolo of NFL Network report.

#1 MLB

Eric Kendricks: Joins active roster

Dec 22nd

Kendricks was elevated from the 49ers' practice squad to the active roster Monday.

#1 LG

Spencer Burford: Ready for MNF

Dec 20th

Burford (ankle) doesn't have an injury designation ahead of Monday night's game against the Colts.

#2 DT2

Jordan Elliott: Ready for Week 16

Dec 20th

Elliott (knee) does not carry an injury designation for Monday's game against the Colts.

#1 RDE

Sam Okuayinonu: Ready to face Colts

Dec 20th

Okuayinonu (ankle) does not carry an injury designation for Monday's game against Indianapolis.

#3 WLB

Nick Martin: Lands on IR

Dec 20th

The 49ers placed Martin (concussion) on injured reserve Saturday.