Isaac Guerendo

24-Year-Old Running BackRB

San Francisco 49ers

Questionable

Injury Knee - MCL

Est. Return 5/1/2025

2024 Rush/Rec Stats

ATT

YDS

420

YDS

152

2025 Projections

ATT

YDS

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2025 Fantasy Outlook

There was no outlook written for Isaac Guerendo in 2025. Check out the latest news below for more on his current fantasy value.

RANKS

Overall

Running Back

Height 6'0"

Weight 221

DOB 6/28/2000

College Louisville

Drafted 4th Rd 2024 #129 Overall

Has MCL, ankle sprains

RBSan Francisco 49ers

Knee - MCL

January 6, 2025

Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, Matt Barrows of The Athletic reports.

ANALYSIS
The 49ers' 2024 campaign is over, but the team's season finale included yet another RB injury. On only his second carry of Sunday's game, Guerendo had his left leg twisted under him as he was tackled, and he needed a cart to go to the locker room. While Guerendo did avoid a more serious ACL injury, he's still one of four San Francisco running backs who will enter the offseason focusing on rehab, along with Christian McCaffrey (knee), Jordan Mason (ankle) and Elijah Mitchell (hamstring). Guerendo, a 2024 fourth-round pick, proved to be effective when given the chance as a rookie, turning 84 carries into 420 yards (5.0 YPC) and four touchdowns and hauling in 15 of 16 targets for 152 yards in 16 appearances.

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NFL Stats

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Fantasy/Red Zone Stats

See red zone opportunities inside the 20, 10 and 5-yard lines along with the percentage of time they converted the opportunity into a touchdown.

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Advanced NFL Stats

How do Isaac Guerendo's 2024 advanced stats compare to other running backs?

This section compares his advanced stats with players at the same position. The bar represents the player's percentile rank. For example, if the bar is halfway across, then the player falls into the 50th percentile for that metric and it would be considered average. The longer the bar, the better it is for the player.

Broken Tackle %
The number of broken tackles divided by rush attempts.
Positive Run %
The percentage of run plays where he was able to gain positive yardage.
% Yds After Contact
The percentage of his rushing yards that came after contact.
Avg Yds After Contact
The average rushing yards he gains after contact.
Rushing TD %
Rushing touchdowns divided by rushing attempts. In other words, how often is he scoring when running the ball.
Touches Per Game
The number of touches (rushing attempts + receptions) he is averaging per game
% Snaps w/Touch
The number of touches (rushing attempts + receptions) divided by offensive snaps played.
Air Yards Per Game
The number of air yards he is averaging per game. Air yards measure how far the ball was thrown downfield for both complete and incomplete passes. Air yards are recorded as a negative value when the pass is targeted behind the line of scrimmage. All air yards data is from Sports Info Solutions and does not include throwaways as targeted passes.
Air Yards Per Snap
The number of air yards he is averaging per offensive snap.
% Team Air Yards
The percentage of the team's total air yards he accounts for.
% Team Targets
The percentage of the team's total targets he accounts for.
Avg Depth of Target
Also known as aDOT, this stat measures the average distance down field he is being targeted at.
Catch Rate
The number of catches made divided by the number of times he was targeted by the quarterback.
Drop Rate
The number of passes he dropped divided by the number of times he was targeted by the quarterback.
Avg Yds After Catch
The number of yards he gains after the catch on his receptions.
% Targeted On Route
Targets divided by total routes run. Also known as TPRR.
Avg Yds Per Route Run
Receiving yards divided by total routes run. Also known as YPRR.

Broken Tackle %

10.7%

Positive Run %

81.0%

% Yds After Contact

79.3%

Avg Yds After Contact

4.0

Rushing TD %

4.8%

Touches Per Game

6.2

% Snaps w/Touch

45.0%

Air Yards Per Game

3.1

Air Yards Per Snap

0.23

% Team Air Yards

1.2%

% Team Targets

3.1%

Avg Depth of Target

3.1 Yds

Catch Rate

93.8%

Drop Rate

0.0%

Avg Yds After Catch

7.1

% Targeted On Route

16.2%

Avg Yds Per Route Run

1.54

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2024

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Snap Distribution / Depth Chart

Snap Counts

Snap %

49ers 2024 RB Snap Distribution See more data like this | See last season's snap counts

J.Jordan Mason

I.Isaac Guerendo

P.Patrick Taylor

C.Christian McCaffrey

K.Ke'Shawn Vaughn

#% of Team Snaps

35935%

22021%

16316%

15715%

30%

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#2 RB

49ers

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Receiving Alignment Breakdown

See where Isaac Guerendo lined up on the field and how he performed at each spot.

Detailed

Grouped

Side

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2024 Isaac Guerendo Split Stats

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Measurables Review View College Player Page

How do Isaac Guerendo's measurables compare to other running backs?

This section compares his draft workout metrics with players at the same position. The bar represents the player's percentile rank. For example, if the bar is halfway across, then the player falls into the 50th percentile for that metric and it would be considered average.

Height

6' 0"

Weight

221 lbs

40-Yard Dash

4.33 sec

Shuttle Time

4.15 sec

Cone Drill

6.94 sec

Vertical Jump

41.5 in

Broad Jump

129 in

Hand Length

9.25 in

Arm Length

30.75 in

Recent RotoWire Articles Featuring Isaac Guerendo See More

NFL Free Agency: Breaking Down All 32 Teams

7 days ago

A third-down back no more: Jaylen Warren should be the next starting runner in Pittsburgh with Najee Harris off to the Chargers.

Best Ball Journal: Post-Combine ADP Movement Among Rookies

17 days ago

Jerry Donabedian looks at rookies whose ADPs shifted after the NFL Scouting Combine, including some like Ashton Jeanty who didn't even go through workouts.

NFL Best Ball Strategy: Analyzing 2025 ADPs on Underdog and Drafters

36 days ago

The popularity of Cincinnati stacks seems to be inflating ADPs for Tee Higgins and Joe Burrow. RW's Jerry Donabedian has the full scoop, looking at early ADP results from two best-ball sites.

Fantasy Football Rankings: Initial PPR Top 200 for 2025

41 days ago

RotoWire's Jerry Donabedian compares his Top 200 to early ADP and finds that most drafters don't share his optimism about Bucky Irving and Courtland Sutton.

2024 Fantasy Outlook

A 4.33 40-yard time and a strong overall performance at the Combine launched Guerendo up draft boards, and the 49ers traded up in the fourth round to make sure they got the 221-pound speedster. Kyle Shanahan's offense is arguably the best in the league for a running back, especially one with game-breaking speed, though Guerendo figures to begin his career behind three-down workhorse Christian McCaffrey and the brittle Elijah Mitchell. Guerendo was never a lead back during his time at Wisconsin and Louisville, but he averaged 6.1 yards on 132 carries for the Cardinals last season and now becomes one of the fastest running backs in the NFL.

More Fantasy News

MCL sprain likely, tests upcoming

RBSan Francisco 49ers

Knee

January 5, 2025

Coach Kyle Shanahan said after Sunday's 47-24 loss to the Cardinals that Guerendo (knee/ankle) likely suffered an MCL sprain and will undergo further testing Monday, Lindsey Pallares of the 49ers' official site reports.