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Saints vs Cardinals Odds, Lines, Spreads & Totals 2025

Cardinals
24.0 Pts
Saints
18.5 Pts
Sunday September 7, 2025 at 1:00 PM ET
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Cardinals Lineup
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Cardinals News
#2 SCB
Jaylon Jones: Two tackles in preseason debut
Aug 10th
Jones (shoulder) recorded two solo tackles in Saturday's 20-17 preseason win over the Chiefs.
#2 FS
Joey Blount: Four tackles versus KC
Aug 10th
Blount (illness) recorded four total tackles (two solo) in Saturday's 20-17 preseason win over the Chiefs.
#1 P
Blake Gillikin: Over foot injury
Aug 10th
Gillikin (foot) punted three times in Saturday's preseason opener against the Chiefs.
#2 RT
Christian Jones: Injures knee
Aug 10th
Cardinals head coach Jonathan Gannon said Saturday that Jones suffered a knee injury during the team's preseason opener, Bo Brack of GoPHNX.com reports.
#2 RB
Trey Benson: Strong start to preseason
Aug 9th
Benson rushed nine times for 29 yards and brought in his only target for 20 yards during the Cardinals' 20-17 preseason win over the Chiefs on Saturday night.
#11 WR
Trishton Jackson: Has thumb injury
Aug 9th
Cardinals head coach Jonathan Gannon said Saturday that Jackson picked up a thumb injury during Saturday's 20-17 preseason win over the Chiefs, Josh Weinfuss of ESPN.com reports.
#1 RB
James Conner: Three carries to open preseason
Aug 9th
Conner rushed three times for 11 yards in the Cardinals' 20-17 preseason win over the Chiefs on Saturday night.
#1 WR
Marvin Harrison: Flashes on one catch Saturday
Aug 9th
Harrison brought in his only target for 15 yards in the Cardinals' 20-17 preseason win over the Chiefs on Saturday night.
#1 TE
Trey McBride: Big gain on one reception
Aug 9th
McBride brought in his only target for 21 yards during the Cardinals' 20-17 preseason win over the Chiefs on Saturday night.
#1 QB
Kyler Murray: Exceeds 100 total yards Saturday
Aug 9th
Murray completed seven of eight passes for 96 yards with no touchdowns and one interception while adding two rushes for nine yards during the Cardinals' 20-17 preseason win over the Chiefs on Saturday night.
#2 WR
Michael Wilson: Ditches non-contact jersey
Aug 7th
Wilson (concussion) practiced Thursday without a yellow non-contact jersey, Tyler Drake of ArizonaSports.com reports.
#3 RG
Will Hernandez: Re-ups with Arizona for one year
Aug 7th
Hernandez (knee) signed a one-year contract with the Cardinals on Thursday, Mike Garafolo of NFL Network reports.
#3 WR
Zay Jones: First-teamer on initial depth chart
Aug 4th
Jones is listed among the first-team offense on the Cardinals' first unofficial depth chart of training camp, Bo Brack of GoPHNX.com reports.
#4 LT
Valentin Senn: Set to miss 2025 season
Aug 3rd
Senn (undisclosed) was placed on injured reserve by the Cardinals on Sunday, Aaron Wilson of KPRC 2 Houston reports.
#3 SLB
BJ Ojulari: Uncertain for Week 1
Aug 3rd
Ojulari (knee) is progressing well, but Cardinals head coach Jonathan Gannon wasn't ready Saturday to commit to the defensive end being ready for Week 1 of the regular season, Theo Mackie of The Arizona Republic reports.
#10 WR
Nate McCollum: Gets chance with Cardinals
Aug 3rd
Arizona signed McCollum on Saturday.
#3 LCB
Elijah Jones: Participating at camp
Jul 31st
Jones (ankle) is practicing at the Cardinals' camp this week, Tyler Drake of ArizonaSports.com reports.
#1 RT
Jonah Williams: Healthy at camp
Jul 31st
Williams (knee) has been healthy for the start of the Cardinals' camp, Theo Mackie of the Arizona Republic reports.
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Saints News
#2 C
Will Clapp: Dealing with significant injury
Aug 11th
Clapp (foot) is expected to miss significant time, Nick Underhill of NewOrleans.Football reports.
#2 RCB
Rico Payton: Active for preseason opener
Aug 11th
Payton (illness) was active for the Saints' 27-13 preseason loss to the Chargers on Sunday.
#3 LILB
D'Marco Jackson: Checks into preseason opener
Aug 11th
Jackson (ankle) recorded one tackle (one solo) and a pass defensed during Sunday's 27-13 preseason loss against the Chargers.
#2 RILB
Jaylan Ford: Collects eight tackles Sunday
Aug 11th
Ford (fibula) recorded eight tackles (five solo) during Sunday's 27-13 preseason loss against the Chargers.
#1 TE
Juwan Johnson: Suits up for preseason loss
Aug 11th
Johnson (groin) played with the first-team offense during New Orleans' 27-13 preseason loss to the Chargers on Sunday.
#3 QB
Jake Haener: Third QB in the game Sunday
Aug 10th
Haener completed five of his eight pass attempts for 41 yards and an interception during Sunday's 27-13 preseason loss to the Chargers.
#5 RB
Clyde Edwards-Helaire: Sees action in second half Sunday
Aug 10th
Edwards-Helaire logged four carries for six yards and caught his lone target for nine yards during Sunday's 27-13 preseason loss to the Chargers.
#7 WR
Kevin Austin: Sees five targets Sunday
Aug 10th
Austin caught four of five targets for 42 yards during Sunday's 27-13 preseason loss to the Chargers.
#2 WR
Rashid Shaheed: Sits out preseason opener
Aug 10th
Shaheed did not play in Sunday's 27-13 preseason loss to the Chargers.
#6 WR
Mason Tipton: Scores 54-yard touchdown Sunday
Aug 10th
Tipton logged one reception (three targets) for 54 yards and one touchdown during Sunday's 27-13 preseason loss to the Chargers.
#1 LG
Trevor Penning: Injured in preseason opener
Aug 10th
Penning was carted to the locker room with an undisclosed injury Sunday against the Chargers, John Hendrix of AthlonSports.com reports.
#4 RB
Cam Akers: Third RB to see touches Sunday
Aug 10th
Akers had four carries for nine yards and was not targeted as a receiver in Sunday's 27-13 preseason loss to the Chargers.
#2 RB
Kendre Miller: Underwhelming against LAC
Aug 10th
Miller took six carries for 15 yards and brought in his only target for nine receiving yards in Sunday's 27-13 preseason loss to the Chargers.
#2 QB
Tyler Shough: Mixed results as backup Sunday
Aug 10th
Shough completed 15 of 22 pass attempts for 165 yards, one touchdown and one interception with one rushing attempt for three yards in Sunday's 27-13 preseason loss to the Chargers.
#1 QB
Spencer Rattler: Fumbles in first preseason start
Aug 10th
Rattler completed seven of 11 pass attempts for 53 yards and rushed three times for 22 yards while losing a fumble in Sunday's 27-13 preseason loss to the Chargers.
#4 WR
Bub Means: Leaves with apparent injury
Aug 10th
Means (lower leg) exited Sunday's preseason game against the Chargers due to an apparent lower leg injury, Jeff Nowak of Audacy Sports reports.
#1 WR
Chris Olave: Unlikely to play Sunday
Aug 10th
Based on pregame warmups, Olave (ankle) is not in line to play in Sunday's preseason opener against the Chargers, Luke Johnson of The New Orleans Times-Picayune reports.
#4 QB
Hunter Dekkers: Inks deal with New Orleans
Aug 6th
The Saints signed Dekkers on Wednesday, Luke Johnson of The New Orleans Times-Picayune reports.
#1 RB
Alvin Kamara: Won't play Sunday
Aug 5th
Saints coach Kellen Moore said Tuesday that Kamara will not suit up for Sunday's preseason opener against the Chargers, Nick Underhill of NewOrleans.Football reports.
#3 RB
Devin Neal: Out a few weeks
Aug 5th
Saints coach Kellen Moore said Tuesday that Neal (hamstring) will miss "a few weeks" of practice, Nick Underhill of NewOrleans.Football reports.
#3 RDE
John Ridgeway: Returns to practice
Aug 3rd
Ridgeway (undisclosed) returned to practice with the Saints on Saturday, Matthew Paras of The New Orleans Times-Picayune reports.
#6 TE
Treyton Welch: Returns to practice
Aug 3rd
Welch (undisclosed) was an active participant at the Saints' practice Saturday, Nick Underhill of NewOrleans.Football reports.
#4 LG
Nick Saldiveri: Slated to miss all of 2025
Aug 3rd
Saldiveri (knee) was placed on injured reserve Saturday, Mike Triplett of NewOrleans.Football reports.
#2 RG
Shane Lemieux: Signs with New Orleans
Aug 1st
The Saints signed Lemieux (knee) on Friday, Mike Garafolo of NFL Network reports.