Top MLB Betting Picks for September 16

Get the best MLB bets today as Michael Rathburn breaks down his expert picks for Tuesday's action. Is this a good spot to back the White Sox at home?
Top MLB Betting Picks for September 16
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Top MLB Betting Picks for September 16: Expert Predictions and Best Bets

Previous article 0-1  ( -1.00 units)  (Dodgers/Giants picks were voided as Logan Webb did not start)

Season 132-138-2 (-10.05 units)

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Key MLB Betting Trends and Matchups Analysis

Before locking in your MLB bets Tuesday, be sure to check out these key betting numbers.

As teams fall out of the playoff race, we will start to see inflated moneylines.

Road Favorites - Braves -190 at Nationals

Home Favorites - Brewers -255 vs Angels 

Totals - Marlins/Rockies 10.0-10.5, Braves/Nationals 7.0, Cubs/Pirates 7.0-7.5

Line Movement - Guardians -51, Yankees -26, 

Guardians/Tigers 7.0 to 8.0

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Chicago Cubs vs Pittsburgh Pirates Best Bets and Predictions

I have been doing this all season and no reason to stop now. We are going to bank on Paul Skenes not allowing a run in the first three innings.  Cade Horton on the other side for the Cubs has been impressive and should win the NL Rookie of the Year. 

Both starting pitchers have ERA's sub 1.60 in their last 7 starts. Horton has a 1.24 ERA in his last 7 starts with just 2 homeruns allowed along with a 36:7 K:BB ratio. The Cubs are averaging 4.0 runs per game in their last 10 and the Pirates are at just 2.8 runs per game over their last 10. 

As I writing this article on Monday night, I had locked in the total of 7.5 to the UNDER and sure enough the line already moved to 6.5-7.0. This one will most likely get to 6.5 across the board, so grab it quickly if you can find a 7.0. 

Best Bet: Cubs UNDER 0.5 runs for 1 unit (DraftKings ); Cubs/Pirates UNDER 7.0 runs for 1 unit (Caesars -109)

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Baltimore Orioles vs Chicago White Sox Best Bets and Predictions

It is not often that you find the White Sox as home favorites (first time in 2025), but they deserve it here with Shane Smith pitching against Dean Kremer. Smith has actually gotten the win in 3 out of his last 4 starts, which says a lot pitching for the White Sox. Kremer has not pitched terribly, but he got walloped in two starts against the Giants and Astros, which have blown up his overall stats. Kremer is also returning to the mound after having his last start skipped due to forearm discomfort.

The White Sox are just 3 games under .500 since the All-Star Break (25-28). 

Best Bet: White Sox ML for 1 unit (FanDuel -130)

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Tuesday's MLB Best Bets

  • Cubs UNDER 0.5 runs for 1 unit (DraftKings )
  • Cubs/Pirates UNDER 7.0 runs for 1 unit (Caesars -109)
  • White Sox ML for 1 unit (FanDuel -130)
  • BONUS PICK - Phillies ML for 1 unit (BetRivers +100). Love getting Cristopher Sanchez at EVEN money against the Dodgers who are still not playing great and the Phillies are heating up again.
  • BONUS PICK - Padres ML for 1 unit () I can not get behind the Mets at all right now. 
ABOUT THE AUTHOR
Known as “Rath” in the Daily Fantasy Sports (DFS) community, he has helped run operations for two prominent daily fantasy sports startups. Michael has taken his insider knowledge and expertise in daily fantasy sports to the content side. Rath won the 2016 FSWA "Baseball Article of the Year, Online" award and was a finalist for the FSWA Best Baseball Series in 2011.
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