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Brock Purdy
Multi-week absence on table
Purdy, who's sitting out Thursday night's game against the Rams, is considered week-to-week, Grant Gordon of NFL.com reports.
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Christian McCaffrey
Massive volume likely again
McCaffrey could see an increase in the 25 touches per game he's averaging thus far this season during Thursday night's contest against the Rams, as multiple 49ers skill-position players will be sidelined due to injury, Nick Wagoner of ESPN.com reports.
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Demarcus Robinson
Big role in second game?
Robinson, who just made his 49ers debut in Sunday's Week 4 loss to the Jaguars after serving a season-opening three-game suspension, is projected to serve as one of San Francisco's top two wide receivers in Thursday's game against the Rams, Nick Wagoner of ESPN.com reports.
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Jauan Jennings
Sitting out vs. Rams
Jennings will not play in Thursday night's Week 5 matchup against the Rams due to ankle and ribs injuries, Nick Wagoner of ESPN.com reports.
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Ricky Pearsall
Won't play Week 5
Pearsall has been ruled out for Thursday night's game against the Rams due to his knee injury, Nick Wagoner of ESPN.com reports.
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Mac Jones
Back in starting role Thursday
Jones will draw his third start in five games in Thursday night's divisional matchup against the Rams due to Brock Purdy being sidelined with his toe injury, Nick Wagoner of ESPN.com reports.
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Brock Purdy
Officially out Thursday
Purdy has been ruled out for Thursday's Week 5 divisional matchup against the Rams due to his toe injury, Nick Wagoner of ESPN.com reports.
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Brock Purdy
Hoping to start Week 5
Purdy expressed optimism that he'll be able to play through a toe injury to start in Week 5 against the Rams, David Lombardi of SFStandard.com reports.
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Ricky Pearsall
Expects to play Sunday
Pearsall, who's listed as questionable due to a knee injury for Sunday's Week 4 clash against the Jaguars, said earlier in the week he expects to play, Nick Wagoner of ESPN.com reports.
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Jauan Jennings
Iffy again for Week 4
Jennings only logged a limited Friday practice this week and appears headed for another game-time decision for Sunday's home matchup against the Jaguars due to his shoulder and ankle injuries, Nick Wagoner of ESPN.com reports.
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Mac Jones
Back to No. 2 role, at best, Sunday
Jones appears slated to operate as no better than the No. 2 quarterback for the 49ers' Week 4 game against the Jaguars due to Brock Purdy's confirmed availability for the game and Jones' own questionable tag because of a PCL sprain, Nick Wagoner of ESPN.com reports.
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Brock Purdy
Confirmed as Week 4 starter
Purdy, who's missed the last two games with shoulder and toe injuries, will start Sunday's Week 4 contest against the Jaguars, Nick Wagoner of ESPN.com reports.
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Nick Bosa
MRI coming for knee injury
Bosa will undergo an MRI for the knee injury that forced his exit from Sunday's win over the Cardinals, Nick Wagoner of ESPN.com reports.
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Mac Jones
Facing depleted Cards secondary
Jones and the 49ers face a Cardinals defense Sunday that could be without its two starting outside corners, Will Johnson and Max Melton.
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Jauan Jennings
Headed for another game-time call
Jennings failed to practice all week due to shoulder and ankle injuries and is listed as questionable for Sunday's Week 3 matchup against the Cardinals, Nick Wagoner of ESPN.com reports.
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Brock Purdy
'Highly unlikely' to start Sunday
Purdy's chances of starting Sunday's Week 3 matchup against the Cardinals has been termed "highly unlikely" by head coach Kyle Shanahan, Nick Wagoner of ESPN.com reports.
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Mac Jones
Slated for another start Sunday
Jones is expected to draw a second consecutive start in Sunday's Week 3 matchup against the Cardinals due to Brock Purdy's toe injury, Nick Wagoner of ESPN.com reports.
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Mac Jones
Still getting first-team reps
Jones has been first up for quarterback reps in individual drills during the first two practice sessions of the week, keeping the No. 2 signal-caller prepared in the event Brock Purdy isn't able to suit up for Sunday's Week 3 matchup against the Cardinals, Nick Wagoner of ESPN.com reports.
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Brock Purdy
May be 'game-time' call Sunday
Purdy said Thursday that his turf toe variant is a day-to-day concern, and the 49ers "gotta see at game time how I feel" Sunday against the Cardinals, Matt Barrows of The Athletic reports.
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Mac Jones
Week 3 return possible for Purdy
Jones, who threw for 279 yards and three touchdowns in a Week 2 spot start against the Saints, might move back to the No. 2 role in Sunday's Week 3 matchup against the Cardinals due to Brock Purdy potentially making his return from toe and shoulder injuries, Nick Wagoner of ESPN.com reports.
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Brock Purdy
Could make Week 3 return
Purdy, who missed the Week 2 win over the Saints with toe and shoulder injuries, has a chance to return for Sunday's Week 3 matchup against the Cardinals, Nick Wagoner of ESPN.com reports.
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Eddy Pineiro
SF's kicker moving forward
Pineiro agreed to a one-year contract with the 49ers on Tuesday, per Adam Schefter of ESPN, after the team waived Jake Moody earlier in the day.
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Ricky Pearsall
Mixed outlook for Week 2
Pearsall should be in line for a boost in targets in Sunday's Week 2 matchup against the Saints due to injuries to other pass catchers, but he's likely to be working with No. 2 quarterback Mac Jones, Nick Wagoner of ESPN.com reports.
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Christian McCaffrey
Offensive unit in shambles
McCaffrey could face the Saints in Week 2 without Brock Purdy and Jauan Jennings in addition to George Kittle due to multiple injuries, Nick Wagoner of ESPN.com reports.
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Mac Jones
Could have multi-game run
Jones could be set to start multiple games in place of Brock Purdy, who's dealing with shoulder and toe injuries, Nick Wagoner of ESPN.com reports.
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