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Jordan Mason
Starter through Week 6
With Christian McCaffrey not expected to return from injured reserve when eligible for Week 6 against the Seahawks, Mason will continue to serve as the 49ers' starting running back, Adam Schefter of ESPN reports.
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Trent Williams
Not considering retirement
Williams is not considering retirement, David Bonilla of the 49erswebzone.com reports.
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Ricky Pearsall
Expected to resume practicing
Pearsall is likely to be activated from the NFI list and return to practice with the 49ers when first eligible this week, Nick Wagoner of ESPN.com reports.
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Deebo Samuel
Garners questionable tag for Week 4
Samuel, who missed the Week 3 loss to the Rams with a calf injury, is listed as questionable for Sunday's Week 4 contest versus the Patriots, Nick Wagoner of ESPN.com reports.
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George Kittle
Expected to play Week 4
Kittle, who missed the Week 3 loss to the Rams with a hamstring injury, is expected to play in Sunday's Week 4 matchup against the Patriots, Nick Wagoner of ESPN.com reports.
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Jauan Jennings
Historic effort in Week 3 loss
Jennings became the first 49ers wide receiver since Jerry Rice in 1995 to post at least 10 catches, 150 yards and three touchdowns in a game during Sunday's 27-24 loss to the Rams, David Lombardi of the San Francisco Standard reports.
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Brandon Aiyuk
Could see massive target volume
Aiyuk is set to see a significant increase in targets due to George Kittle now being likely to join Deebo Samuel as pass catchers sidelined for Sunday's Week 3 game against the Rams, per Nick Wagoner of ESPN.com.
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Jauan Jennings
Could be very busy Sunday
Jennings is set to draw a start in place of the injured Deebo Samuel in Sunday's game against the Rams and could see even more targets due to George Kittle now being doubtful for the contest as well, Nick Wagoner of ESPN.com reports.
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Brock Purdy
Likely to play very short-handed
Purdy appears headed toward having to play Sunday's game against the Rams without three key offensive weapons, Nick Wagoner of ESPN.com reports.
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Charvarius Ward
Carrying questionable tag in Week 3
Ward is questionable to play in Sunday's game against the Rams due to hamstring and knee soreness, Nick Wagoner of ESPN.com reports.
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Nick Bosa
Questionable to play Sunday
Bosa, who sustained a rib injury in Thursday's practice, is questionable to play Sunday against the Rams, Nick Wagoner of ESPN.com reports.
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George Kittle
Doubtful for Week 3
Kittle, who is dealing with a hamstring injury, is listed as doubtful to play against the Rams in Sunday's Week 3 matchup, Nick Wagoner of ESPN.com reports.
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Jacob Cowing
May be asked to step up
Cowing could be used as a replacement for Deebo Samuel in the "gadget player" role, Matt Barrows of The Athletic reports.
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Brock Purdy
Sans key weapon again Sunday
Purdy will be helming a 49ers offense without Christian McCaffrey for the second straight game in Week 2 against the Vikings, Nick Wagoner of ESPN.com reports.
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Deebo Samuel
Bigger role to persist
Samuel is likely to see more rushing opportunities as a complement to his receiver role in the coming weeks, as Nick Wagoner of ESPN.com reports Christian McCaffrey is a candidate for injured reserve.
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Jordan Mason
Multi-game starting stint possible
Mason is a candidate to serve as the 49ers' starting running back beyond Sunday's Week 2 game against the Vikings, as San Francisco is considering placing Christian McCaffrey on injured reserve with a designation to return, per Nick Wagoner of ESPN.com.
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Christian McCaffrey
IR becomes a possibility
McCaffrey, who was ruled out Friday for Sunday's Week 2 game against the Vikings, could be headed to injured reserve due to his Achilles and calf injuries, Nick Wagoner of ESPN.com reports.
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Christian McCaffrey
Trending toward sitting again
McCaffrey is considered a longshot to play Sunday versus the Vikings due to Achilles and calf injuries, per Ian Rapoport of NFL Network.
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Jordan Mason
Could get another start Week 2
Mason could be poised to lead San Francisco's backfield again in Week 2 against the Vikings, as Ian Rapoport of NFL Network reports that Christian McCaffrey is considered a long shot to play due to Achilles and calf injuries.
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Christian McCaffrey
Inactive status 'group decision'
McCaffrey said Wednesday that the decision to make him inactive for Monday's win over the Jets was made in conjunction with the coaching and training staff and viewed as a prudent one with respect to the rest of the season, Nick Wagoner of ESPN.com reports.
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Talanoa Hufanga
Chance to return in Week 2
Hufanga has the chance to play Week 2 against Minnesota, David Bonilla of 49erswebzone.com reports.
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Christian McCaffrey
Would have played in postseason
Coach Kyle Shanahan said that McCaffrey would have played Monday night against the Jets had it been a postseason game, David Bonilla of 49erswebzone.com reports.
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Jauan Jennings
Bigger role for Week 1?
Jennings could see a larger workload on offense during Monday's game against the Jets due to Brandon Aiyuk operating on a reduced snap count, Nick Wagoner of ESPN.com reports.
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Christian McCaffrey
Expecting usual workload Week 1
McCaffrey, who's been dealing with calf and Achilles injuries since early in training camp, expects to play and handle his usual workload in Monday night's Week 1 matchup against the Jets, Nick Wagoner of ESPN.com reports.
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Joshua Dobbs
Third on QB depth chart
Dobbs will begin the season as San Francisco's third-string quarterback, as coach Kyle Shanahan said Thursday that Kyle Allen will back up Brock Purdy against the Jets in Monday's regular-season opener, per Eric Branch of the San Francisco Chronicle.
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