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Chargers vs Chiefs Odds, Lines, Spreads & Totals 2025

Chiefs
24.3 Pts
Chargers
21.3 Pts
Friday September 5, 2025 at 8:00 PM ET
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KC
Chiefs Injury Report
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LAC
Chargers Injury Report
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KC
Chiefs Lineup
Inactives
    None reported yet.
LAC
Chargers Lineup
Inactives
    None reported yet.
KC
Chiefs News
#2 MLB
Jack Cochrane: Recovered from knee injury
Sep 2nd
Cochrane (knee) was listed as a full participant in Tuesday's practice report.
#1 WLB
Drue Tranquill: Logs full practice
Sep 2nd
Tranquill (back) was a full participant in Tuesday's practice.
#4 WR
Jalen Royals: DNP on Tuesday
Sep 2nd
Royals (knee) did not practice Tuesday, Pete Sweeney of ArrowheadPride.com reports.
#2 WR
Hollywood Brown: Good to go for Week 1
Sep 2nd
Kansas City head coach Andy Reid said Tuesday that Brown (ankle) has been a full practice participant this week and will be available for Friday's season opener versus the Chargers in Sao Paulo, Brazil, Sam McDowell of The Kansas City Star reports.
#4 TE
Robert Tonyan: Signed to active roster
Aug 28th
The Chiefs signed Tonyan from their practice squad to their active roster Thursday, Aaron Wilson of KPRC 2 Houston reports.
#2 LCB
Nazeeh Johnson: Moves to IR, designated to return
Aug 27th
Johnson (shoulder) was placed on injured reserve Tuesday with a designation to return.
#3 MLB
Brandon George: Placed on injured reserve
Aug 27th
George (undisclosed) was placed on injured reserve Tuesday.
#2 RG
Ethan Driskell: Starting season on NFI List
Aug 27th
Driskell (appendix) was placed on the reserve/non-football injury list Tuesday.
#8 WR
Rashee Rice: Six-game suspension made official
Aug 27th
The NFL officially suspended Rice for the first six games of the 2025 regular season Wednesday for violating the league's Personal Conduct Policy, Ian Rapoport of NFL Network reports.
#5 TE
Jake Briningstool: Starting season on IR
Aug 26th
The Chiefs placed Briningstool (hamstring) on injured reserve Tuesday with a designation to return, per the NFL's transaction log.
#1 RCB
Kristian Fulton: Tallies five stops
Aug 24th
Fulton recorded five tackles, a tackle for loss and a pass defensed in Friday's 29-27 preseason loss to the Bears.
#2 RCB
Nohl Williams: Two tackles in preseason defeat
Aug 24th
Williams (concussion) recorded two solo tackles in Friday's 29-27 preseason loss to the Bears.
#1 SCB
Jaylen Watson: Past concussion
Aug 24th
Watson recorded one pass defended in Friday's 29-27 preseason loss to the Bears.
#2 DT2
Derrick Nnadi: Going back to KC
Aug 24th
The Jets traded Nnadi to the Chiefs on Sunday in exchange for a conditional 2027 draft-pick swap, Jeremy Fowler of ESPN.com reports.
#1 WR
Xavier Worthy: Grabs one reception Friday
Aug 22nd
Worthy brought in his only target for nine receiving yards in Friday's 29-27 preseason loss to the Bears.
#2 RB
Kareem Hunt: Active for preseason finale
Aug 22nd
Hunt (quadriceps) took three carries for 15 yards and failed to bring in his only target in Friday's 29-27 preseason loss to Chicago.
#1 TE
Travis Kelce: Shakes off rust with two grabs
Aug 22nd
Kelce corralled two of three targets for 32 yards in Friday's preseason loss to Chicago.
#1 RB
Isiah Pacheco: Cracks end zone Friday
Aug 22nd
Pacheco rushed three times for 21 yards and a touchdown without receiving a target in Friday's preseason loss to the Bears.
#1 QB
Patrick Mahomes: Looks sharp in dress rehearsal
Aug 22nd
Mahomes completed eight of 13 pass attempts for 143 yards and a touchdown while adding 18 rushing yards on one attempt in Friday's 29-27 preseason loss to the Bears.
LAC
Chargers News
#1 RG
Mekhi Becton: Absent from injury report
Sep 2nd
Becton (undisclosed) was not listed on the Chargers' injury report Tuesday.
#4 WR
Tre' Harris: In clear for Week 1
Sep 2nd
Harris (undisclosed) isn't listed on the Chargers' initial Week 1 injury report that was released Tuesday.
#2 WR
Quentin Johnston: Off injury report
Sep 2nd
Johnston (concussion) isn't listed on the Chargers' initial Week 1 injury report that was released Tuesday.
#2 RB
Najee Harris: Turns in full practice
Sep 2nd
Harris (eye) was listed as a full practice participant Tuesday.
#2 LT
Austin Deculus: Gets traded to Chargers
Aug 30th
Houston traded Deculus to the Chargers on Tuesday in exchange for a conditional seventh-round pick, Omar Navarro of the Chargers' official site reports.
#4 RCB
Eric Rogers: Placed on IR
Aug 27th
Rogers (undisclosed) was placed on injured reserve by the Chargers on Wednesday.
#2 LCB
Deane Leonard: Placed on IR, designated to return
Aug 27th
Leonard (leg) was placed on injured reserve with a designation to return Wednesday.
#1 LS
Josh Harris: Placed on IR, designated to return
Aug 27th
Harris (undisclosed) was placed on injured reserve with a designation to return Tuesday.
#3 RILB
Junior Colson: Placed on season-ending IR
Aug 27th
The Chargers placed Colson (shoulder) on injured reserve Tuesday, ruling him out for the entire 2025 season,
#1 K
Cameron Dicker: Perfect in preseason finale
Aug 23rd
Dicker made all three of his field-goal attempts and both of his extra-point attempts in Saturday's 30-23 preseason loss to the 49ers.
#3 TE
Oronde Gadsden: Makes touchdown grab
Aug 23rd
Gadsden recorded three catches on four targets for 46 yards and a touchdown in Saturday's 30-23 preseason loss.
#2 QB
Trey Lance: Starts final preseason game
Aug 23rd
Lance completed five of eight passes for 38 yards in Saturday's 30-23 preseason loss to the 49ers.
#5 WR
KeAndre Lambert-Smith: No catches to close preseason
Aug 23rd
Lambert-Smith did not record a reception on one target in Saturday's 30-23 preseason loss to the 49ers.
#1 RCB
Cam Hart: Recovered from shoulder surgery
Aug 21st
Hart (shoulder) returned to team drills Wednesday, Daniel Popper of The Athletic reports.