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Chargers vs Chiefs Odds, Lines, Spreads & Totals 2025

Chiefs
24.3 Pts
Chargers
21.3 Pts
Friday September 5, 2025 at 8:00 PM ET
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KC
Chiefs Injury Report
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LAC
Chargers Injury Report
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KC
Chiefs Lineup
Inactives
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LAC
Chargers Lineup
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KC
Chiefs News
#4 TE
Jared Wiley: One catch in preseason opener
Aug 9th
Wiley (undisclosed) brought in his only target for two yards in the Chiefs' 20-17 preseason loss to the Cardinals on Saturday night.
#4 RB
Brashard Smith: Five touches to open preseason
Aug 9th
Smith (finger) rushed four times for 10 yards and brought in in his only target for minus-6 yards in the Chiefs' 20-17 preseason loss to the Cardinals on Saturday night.
#5 WR
Jalen Royals: Totals 40 all-purpose yards in loss
Aug 9th
Royals brought in three of five targets for 14 yards and returned one kickoff for 26 yards in the Chiefs' 20-17 preseason loss to the 49ers on Saturday night.
#2 RB
Kareem Hunt: Three touches in preseason opener
Aug 9th
Hunt rushed twice for 12 yards and brought in one of two targets for five yards during the Chiefs' 20-17 preseason loss to the Cardinals on Saturday night.
#3 SS
Deon Bush: Suffers torn Achilles
Aug 9th
Chiefs coach Andy Reid said Saturday that Bush suffered a torn left Achilles tendon during Saturday's 20-17 preseason loss to the Broncos, Nate Taylor of ESPN.com reports.
#1 RB
Isiah Pacheco: Logs one carry in preseason loss
Aug 9th
Pacheco rushed once for eight yards in the Chiefs' 20-17 preseason loss to the Cardinals on Saturday night.
#1 QB
Patrick Mahomes: Maximizes one completion Saturday
Aug 9th
Mahomes completed his only pass attempt for a one-yard touchdown during the Chiefs' 20-17 preseason loss to the Cardinals on Saturday night.
#1 SCB
Jaylen Watson: Enters concussion protocol
Aug 9th
Watson (concussion) is ruled out for the remainder of Saturday's preseason contest against the Cardinals.
#3 WR
Hollywood Brown: Sitting out preseason opener
Aug 9th
Brown (ankle) isn't playing in Saturday's preseason contest against the Cardinals, Sam McDowell of The Kansas City Star reports.
#1 WR
Rashee Rice: Not playing in preseason opener
Aug 9th
Rice (groin) isn't suiting up for Saturday's preseason matchup versus Arizona, Sam McDowell of The Kansas City Star reports.
#1 RCB
Kristian Fulton: Back at practice
Aug 7th
Fulton (knee) was reinstated from the active/PUP list Thursday and was a limited participant in practice, Pete Grathoff of The Kansas City Star reports.
#4 LCB
Eric Scott: Placed on IR
Aug 3rd
Scott (undisclosed) reverted to injured reserve with Kansas City on Saturday, Aaron Wilson of KPRC 2 Houston reports.
#6 WR
Skyy Moore: Back at practice
Aug 3rd
Moore (hamstring) is practicing Sunday, Matt Derrick of ChiefsDigest.com reports.
#1 WLB
Drue Tranquill: Nursing back injury
Aug 2nd
Tranquill did not participate in Saturday's training camp practice due to a back injury, Matt Derrick of ChiefsDigest.com reports.
#13 WR
Key'Shawn Smith: Headed to Kansas City
Aug 1st
The Chiefs signed Smith on Friday.
#2 WR
Xavier Worthy: Didn't have concussion
Aug 1st
Coach Andy Reid revealed Friday that Worthy, who had been in the NFL's concussion protocol, actually didn't sustain a concussion upon further evaluation Thursday, Nate Taylor of ESPN.com reports.
#5 TE
Jake Briningstool: Misses practice Sunday
Jul 27th
Briningstool (hamstring) didn't participate in Kansas City's practice Sunday, Pete Sweeney of ArrowheadPride.com reports.
#1 RT
Jawaan Taylor: Returns from PUP
Jul 27th
Taylor (undisclosed) was activated from the active/PUP list Sunday, Pete Sweeney of ArrowheadPride.com reports.
#7 TE
Tre Watson: Activated off PUP list
Jul 27th
The Chiefs activated Watson (undisclosed) off the active/PUP list Sunday, Pete Sweeney of ArrowheadPride.com reports.
LAC
Chargers News
#4 LT
Rashawn Slater: Goes on IR
Aug 9th
The Chargers placed Slater (knee) on injured reserve Saturday.
#7 TE
Jordan Petaia: Moved to Bolts' IR
Aug 8th
Petaia (undisclosed) reverted to the Chargers' injured reserve list Friday, per the NFL's transaction log.
#1 RB
Najee Harris: Week 1 status TBD
Aug 8th
Coach Jim Harbaugh was noncommittal Friday about Harris' (eye) status for Week 1, Kris Rhim of ESPN reports.
#1 WR
Ladd McConkey: Taking part in Friday's walkthrough
Aug 8th
McConkey (undisclosed) is taking part in the team walkthrough Friday, Kris Rhim of ESPN.com reports.
#2 QB
Taylor Heinicke: Scheduled for preseason start
Aug 8th
Heinicke will start Sunday's preseason game against the Saints, NFL.com reports.
#1 RT
Trey Pipkins: Bumped up to starting role
Aug 8th
Pipkins is slated to start at right tackle since Rashawn Slater (knee) is out for the season, Ian Rapoport of NFL Network reports.
#1 QB
Justin Herbert: Won't play Sunday
Aug 8th
Herbert won't play in Sunday's preseason game against the Saints, NFL.com reports.
#1 LT
Joe Alt: Moving to LT after Slater injury
Aug 8th
Alt is expected to shift to left tackle in the wake of Rashawn Slater's season-ending knee injury, Kris Rhim of ESPN.com reports.
#6 TE
Thomas Yassmin: Signs with Chargers
Aug 7th
Yassmin signed a contract with the Chargers on Thursday, the team announced.
#4 RDE
Josh Fuga: Reverts to IR
Aug 5th
Fuga (undisclosed) reverted to the Chargers' injured reserve Tuesday, per the NFL's transaction log.
#3 WR
Keenan Allen: Headed back to Los Angeles
Aug 5th
Allen and the Chargers agreed on a one-year, $8.52 million contract Tuesday, Tom Pelissero of NFL Network reports.
#1 RG
Mekhi Becton: Injury not considered serious
Aug 4th
Becton (undisclosed) last practiced on July 28, but Chargers coach Jim Harbaugh described his injury as "not severe" Monday, Daniel Popper of The Athletic reports.
#1 RILB
Denzel Perryman: Has charges dropped
Aug 4th
Perryman, who was arrested Friday on a felony weapons charge, had the charge dropped Monday, Daniel Popper of The Athletic reports.
#1 RDE
Otito Ogbonnia: Dealing with undisclosed issue
Aug 3rd
Ogbonnia exited Saturday's practice with an undisclosed injury and did not return, Kris Rhim of ESPN.com reports.
#2 SCB
Ja'Sir Taylor: Plays in preseason opener
Aug 1st
Taylor (ribs) logged 29 defensive snaps and recorded three tackles (two solo) in Thursday's Hall of Fame Game versus Detroit.
#3 QB
Trey Lance: Good use of starting opportunity
Jul 31st
Lance completed 13 of 20 passes for 120 yards with two touchdowns and no interceptions while adding three rushes for eight yards during the Chargers' 34-7 preseason win over the Lions in Thursday's Hall of Fame Game. He also fumbled once but recovered.
#1 TE
Will Dissly: Finds end zone in preseason opener
Jul 31st
Dissly brought in both targets for 14 yards and a touchdown during the Chargers' 34-7 preseason win over the Lions in Thursday's Hall of Fame Game.
#4 WR
Tre Harris: Fails to bring in only target
Jul 31st
Harris didn't bring in his one target during the Chargers' 34-7 preseason win over the Lions in Thursday night's Hall of Fame Game.
#7 WR
KeAndre Lambert-Smith: Keeps rolling in preseason opener
Jul 31st
Lambert-Smith secured both targets for 43 yards and a touchdown in the Chargers' 34-7 preseason win over the Lions in Thursday night's Hall of Fame Game.
#2 RB
Omarion Hampton: Logs pair of touches in HOF Game
Jul 31st
Hampton rushed twice for nine yards and wasn't targeted during the Chargers' 34-7 preseason win over the Lions in Thursday night's Hall of Fame Game.
#2 WR
Quentin Johnston: Not on track to play Thursday
Jul 29th
Johnston isn't in line to play in Thursday's Hall of Fame Game against the Lions, Eric Smith of the Chargers' official site reports.
#6 WR
Jalen Reagor: Misses another practice
Jul 28th
Reagor (lower body) isn't practicing Monday, Kris Rhim of ESPN.com reports.