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Best Bets for Tampa Bay Buccaneers vs. Buffalo Bills | Tampa Bay Buccaneers +5.5 (-110)
Baker Mayfield and Josh Allen lead their teams into a huge interconference NFL matchup in Orchard Park, New York, at Highmark Stadium this afternoon. Buffalo is a -5.5 point favorite with a 48.5 point total.
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Tampa Bay and Buffalo both lost outright in Week 10. The Buccaneers fell to the red-hot New England Patriots, while the Bills got routed in a shocking upset in Miami.
Buffalo is 2-3 SU in its last five games played. They've lost at home to New England in Week 5 but bounced back with a win over the Chiefs in Week 9 during their last home game.
The Buccaneers have been very good on the road in 2025. Aside from a 24-9 loss to Detroit, Tampa Bay has covered +5.5 in four of five road contests, including a big-time win over the Seattle Seahawks in Week 5.
Buffalo's run defense is porous and struggles to contain opposing running backs. The Buccaneers are expected to get RB1 Bucky Irving back for this game, so let's bet Tampa Bay +5.5 against the Bills.
Best Bets for Tampa Bay Buccaneers vs. Buffalo Bills | Baker Mayfield O 1.5 Passing Touchdowns (-110)
Baker Mayfield's been very reliable as Tampa Bay's franchise quarterback in 2025. Mayfield has thrown two or more touchdowns in six of nine games this season, although he's only gone over this line once in the Buccaneers' previous three outings.
Buffalo has a talented secondary. However, the Bills did give up a pair of passing touchdowns to the Dolphins last weekend.
The Buccaneers will be able to move the football downfield into the red zone, even if Irving winds up sitting out due to injury again. Mayfield has plenty of young talent to target within his wide receiving corps, so let's bet on him to go over 1.5 passing touchdowns at Highmark Stadium today.
Best Bets for Tampa Bay Buccaneers vs. Buffalo Bills | Khalil Shakir O 51.5 Receiving Yards
Let's turn our attention to Buffalo's offense. Specifically, wideout Khalil Shakir.
Shakir has been one of Josh Allen's favorite targets this season. He's racked up at least seven targets in three straight matchups, turning this volume into 88-43-58 receiving yards.
Tampa Bay is typically much better at stopping the run than the pass. New England hit a few big explosive runs to win the game last week. Expect the Buccaneers to be prepared to contain Bills RB1 James Cook and Allen on the ground.
Allen's big arm talent means we may only need three or four receptions for Shakir to hit over 51.5 receiving yards. The Buccaneers have allowed 269 or more passing yards to Mac Jones, Sam Darnold, and Drake Maye in the last five games played.
Shakir is going to have a busy day for Buffalo. Let's bet on him to go over 51.5 receiving yards for the third time in four games.
Tampa Bay Buccaneers vs. Buffalo Bills Picks
- Tampa Bay Buccaneers +5.5 (-110)
- Baker Mayfield O 1.5 Passing Touchdowns (-110)
- Khalil Shakir O 51.5 Receiving Yards (-110)
Best Events to Use the bet365 Bonus Code For November 16
- NFL: Los Angeles Chargers vs. Jacksonville Jaguars. High-stakes AFC matchup with the Chargers laying -2.5 on the road and a 43.5 point total. Kickoff at 1 p.m. ET on CBS.
- NFL: Seattle Seahawks vs. Los Angeles Rams. First meeting between these two NFC West powerhouses in 2025. Rams -3.5 with a 48.5 point total. Kickoff at 4:05 p.m. ET on FOX.
- NHL: Detroit Red Wings vs. New York Rangers. Pair of above .500 Eastern Conference opponents face off at Madison Square Garden. Puck drop at 7 p.m. ET on NHL Network.
- NBA: Miami Heat vs. Philadelphia 76ers. Tyrese Maxey and the 76ers host Jamie Jaquez Jr. and the Heat. Early tip-off at 1 p.m. ET.
- College Basketball: Houston Cougars vs. Auburn Tigers. No. 1 Houston travels to Birmingham to face No. 22 Auburn. 3 p.m. ET tip-off on ESPN.
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