Coming back from a two-goal deficit won't be easy, but if Monaco are to do it, Radamel Falcao will likely be involved.
Juventus come in as the biggest favorite on Tuesday's two-game slate, with fantasy owners likely turning their attention toward Paulo Dybala.
Monaco have to make up a three-goal deficit on Manchester City in order to advance to the quarter-final, but they have two away goals in their pocket to help the cause.
Sunday's three-game interleague slate includes a number of high-impact fantasy options, with Real Madrid's Cristiano Ronaldo all but guaranteed to score at least once.
He put up a dud in Montreal's opener, but RotoWire's JD Bazzo is expecting a bounce-back performance from Ignacio Piatti on Saturday against the Sounders.
Saturday's five-game slate doesn't include a plethora of goal-scorers, with Atletico Madrid's Antoine Griezmann the best bet to score.
Gylfi Sigurdsson is the most expensive player on Saturday's three-game slate, but fading him could make it impossible to score enough points for a winning lineup.
Sacha Kljestan is one of the steadiest fantasy producers in Major League Soccer, but JD Bazzo has his eyes set on a few other Red Bulls for Saturday's early slate.
Juventus will try to avenge their previous Serie A loss to AC Milan, with Gonzalo Higuain leading the charge.
Saturday's eight-game slate features a number of impact players, but the Red Bulls' Bradley Wright-Phillips has the best anytime goal-scoring odds.
Gylfi Sigurdsson is looking at another week of high ownership, but Kevin Swanson explains why the Swans attacker may be unavoidable for fantasy managers.
Saturday's three-game slate does not have a ton of high upside players, but fantasy managers can still turn to Everton's Romelu Lukaku.
Ever want to have a roster with Lionel Messi and Charlie Adam? Now is your chance thanks to DraftKings' three-game slate on Wednesday.
With Barcelona having to make up a four-goal deficit at home against Paris Saint-Germain, Lionel Messi is likely to be firing shots all night.
Borussia Dortmund will try to overturn a 1-0 deficit at home against Benfica, which means all eyes will be on striker Pierre-Emerick Aubameyang.
Despite playing on the road, Robert Lewandowski comes in with the best goal-scoring odds on the slate, but is he worth paying up for?
Diego Costa got back on the goal-scoring track last weekend, and he'll look to start a streak Monday against West Ham.
Barcelona have a significant deficit to make up when they host Paris Saint-Germain on Wednesday, and if they are going to get close, it'll take a huge performance from Lionel Messi.