Arsenal are heavy favorites over West Ham on Wednesday, which means plenty of fantasy managers will be focusing on Alexis Sanchez.
Idrissa Gueye has won the most tackles in the Premier League this season, and he figures to get plenty of opportunities for more Tuesday against Manchester United.
Jamie Vardy has found the back of the net four times in his last four league matches, and he'll look to add to his total Tuesday against Sunderland.
Zlatan Ibrahimovic returns after his four-match suspension, and he comes in with the best anytime goal scoring odds as Manchester United host Everton at Old Trafford.
With Lionel Messi suspended for Sunday's trip to Granada, Barcelona will have to rely more on Neymar, something that should surely peak the interest of fantasy managers.
Despite playing at the Emirates, Manchester City are favored over Arsenal, with Sergio Aguero coming in with the best anytime goal-scoring odds.
Minnesota United have allowed a boatload of goals this season, and with RSL next on the schedule, fantasy managers will certainly be looking toward Albert Rusnak.
With Paul Pogba and Zlatan Ibrahimovic out, Kevin Swanson is looking for Henrikh Mkhitaryan to make a big impact against West Brom.
Yannis Salibur has taken the second-most shots and sent in the most crosses among players in Friday's two-game slate.
Jamie Vardy looks re-born under new manager Craig Shakespeare, and he'll look to continue his solid play on Saturday against Stoke City.
Despite a few players battling niggling injuries, including Eden Hazard, Chelsea are the biggest favorites among Saturday's seven-game slate.
Remember when you said you'd never roster Kei Kamara again in fantasy MLS? Andrew Laird explains why you could go back on your word Saturday.
There will be plenty of eyes on Christian Pulisic during Friday's match against Honduras, but should fantasy managers also see him in their lineups? Adam Zdroik weighs in.
Gylfi Sigurdsson has been one of the best fantasy options in the Premier League this season, and he'll now help lead the Iceland attack as they take on Kosovo in World Cup qualifying.
Lionel Messi is one of the most expensive options on Thursday's four-game CONMEBOL slate, and Tate McIntyre has a number of value plays to help fit the Argentina star in.
Sunday's three-game interleague slate includes three strong favorites, with Barcelona's Lionel Messi coming in with the best anytime goal-scoring odds.
JD Bazzo breaks down the Saturday MLS slate on DraftKings as Dom Dwyer is sure to break into the scoring column at any moment.
With a few elite goal scorers unavailable for Sunday's three-game slate, Manchester City's Sergio Aguero is likely to garner plenty of fantasy attention.