Gonzalo Higuain has scored in nine of his last 10 domestic matches, and he's likely to be involved if Juventus are to take anything out of Wednesday's match at FC Porto.
Sergio Aguero has his starting job back for Manchester City, and he'll look to make an immediate impact this week against Monaco.
Radamel Falcao has resurrected his career with Monaco this season, and he could be a key piece if they are to upset Manchester City in England on Tuesday.
Sergio Aguero is back at the top of the Man City attack, and he'll head into this week's Champions League slate with the best anytime goal-scoring odds.
Saturday's four-game interleague slate doesn't offer a ton of firepower, though Nice's Mario Balotelli is always capable of putting up a big fantasy score.
Looking to bounce back after an embarrassing Champions League loss Tuesday, Barcelona will try to take out their frustrations against relegation-fighting Leganes.
Juventus take on lowly Palermo as part of Friday's three-match interleague slate, which puts the spotlight on striker Gonzalo Higuain.
Cristiano Ronaldo headlines Wednesday's two-game Champions League slate, but is his sky-high price worth the investment?
No player has more fantasy upside on Tuesday's slate than Lionel Messi, and while his salary is sky high, fading him could be very detrimental.
Lionel Messi and Cristiano Ronaldo highlight this week's Champions League slate, but Schuyler Redpath reminds everyone not to forget about Robert Lewandowski.
Despite playing on the road, Manchester City are heavy favorites over Bournemouth on Monday, putting Kevin De Bruyne in consideration for many fantasy players.
Gylfi Sigurdsson is likely to be heavily owned on Sunday's two-game slate, but fantasy owners who decide to fade him could fall behind quickly.
Despite playing away Sunday, Juventus are heavy favorites over Cagliari, who they defeated 4-0 earlier this season.
Diego Costa has only one goal in his last four games, but he'll look to break through against Burnley at Turf Moor on Sunday.
Barcelona travel to France to take on Paris Saint-Germain in the first leg of their Round of 16 matchup, but being away from home doesn't stop them from being favorites.
Henrikh Mkhitaryan looks to be a player to own on Saturday's six-game slate, with Manchester United coming in as heavy favorites against Watford at Old Trafford.
As long as he's taking corners, Stoke's Charlie Adam is going to garner some consideration from daily fantasy soccer players, especially at home against 19th-place Crystal Palace.
Edinson Cavani is extremely goal dependent to produce good fantasy value, but the PSG striker heads into Friday's match with nine goals in his last eight Ligue 1 starts.