Barcelona have to make up a big 3-0 deficit to Juventus, and if they are to do it, it'll take big performances from Lionel Messi and Neymar.
Borussia Dortmund need to make up a big deficit to overcome Monaco, and if they are to do it, Pierre-Emerick Aubameyang is likely to play a part.
Despite struggling lately and being away from home, Arsenal are the biggest favorites on Monday's two-game slate, with Alexis Sanchez expected to carry the load once again.
Sunday's Manchester United v. Chelsea match is expected to be much closer than their initial encounter this season, with United likely to rely heavily on Zlatan Ibrahimovic.
Sacha Kljestan has started off slowly this season, but JD Bazzo is expecting a breakout performance Saturday against D.C. United.
Sergio Aguero has the second-best anytime goal-scoring odds on the slate, but Kevin Swanson explains why he may be a key differential on Saturday.
Romelu Lukaku leads the Premier League in goals scored this season, and he has an excellent opportunity to add to his total Saturday against Burnley.
Romelu Lukaku has a league-high 23 goals this season, and he is expected to add to his total this weekend against Burnley at Goodison Park.
Atletico Madrid are the biggest favorites on this week's slate, but is Antoine Griezmann the best place to go for fantasy points?
The Borussia Dortmund-Monaco matchup is expected to be high scoring, with Pierre-Emerick Aubameyang likely to contribute.
The Champions League quarterfinal matchups are stacked with high-end fantasy options, with Cristiano Ronaldo looking to make an impact against Bayern Munich in Germany.
Manchester United are heavy favorites over Sunderland on Sunday, even at the Stadium of Light, which means many fantasy managers will be looking toward Zlatan Ibrahimovic.
Sebastian Giovinco has struggled to get going this season, but he could finally break out Saturday against Atlanta United at home.
Manchester City are heavy favorites Saturday against Hull City at the Etihad, and getting exposure to their attack will be key.
After a disappointing midweek performance against Spurs, Kevin Swanson dives in to see if it's worth going back to Gylfi Sigurdsson.
Manchester City are the biggest favorites Saturday as they take on Hull City at the Etihad, and bookmakers are expecting a big game from Sergio Aguero.
Arsenal have been struggling of late, but Alexis Sanchez continues to be a very strong fantasy option.
James Milner's price is very high for a defender, but there are a few reasons why he should be in consideration Wednesday against Bournemouth.