Real Madrid need three points to keep their title hopes alive, while Celta Vigo are likely to rest starters ahead of the Europa League final, which means Cristiano Ronaldo could have a huge game Wednesday.
Arsenal have a big hill to climb if they want to finish in the top four, so they'll be relying heavily on Alexis Sanchez to make an impact Tuesday against Sunderland.
Nicolas Lodeiro has arguably been the best fantasy performer this season, and JD Bazzo likes him again at Chicago on Saturday.
Tottenham can clinch a second-place finish with a win Sunday against Manchester United, and fantasy owners will be looking for Harry Kane to do the damage.
Arsenal will look to keep their top-four hopes alive Saturday at Stoke City, and they'll likely need a big performance from Alexis Sanchez.
Swansea City continue to fight off relegation, and while an away match to Sunderland can be tricky, Kevin Swanson is still expecting Gylfi Sigurdsson to come up big.
Eden Hazard could be a popular fantasy option Friday, as Chelsea look to clinch the Premier League title against West Brom at The Hawthorns.
Arsenal continue to fight for a Champions League spot, and they'll need Alexis Sanchez to come up big Saturday at Stoke City.
Real Madrid are slight underdogs this week, but will fantasy owners be bold enough to fade Cristiano Ronaldo?
While plenty of fantasy managers are likely to focus on the two sides that need to make up deficits, Andrew Laird says don't forget about why they are behind.
Atletico Madrid have to make up a big three-goal deficit, and they'll be looking to Antoine Griezmann to lead the comeback.
Chelsea will get very close to clinching the Premier League title with three points Monday against Middlesbrough, and they're likely to rely heavily on Eden Hazard to get there.
Sacha Kljestan's price isn't nearly as high as it's been in the past, and JD Bazzo thinks the Red Bulls midfielder will be a great value Saturday against the Union.
Edin Dzeko has six goals and two assists in his last seven Serie A matches, and he'll look to add to his totals Sunday against AC Milan at the San Siro.
With Manchester United prioritizing the Europa League over their domestic matches, Paul Pogba may not get an opportunity to shine against Arsenal.
Gylfi Sigurdsson ended a 10-match goalless drought last weekend against Manchester United, and he'll now try to find the back of the net against Everton at the Liberty Stadium.
Jamie Vardy has scored seven goals in his last nine games, and no one on Saturday's slate has better anytime goal-scoring odds.
Spurs need to keep winning in order to stay within striking distance of Chelsea for the Premier League title, and they'll look for Harry Kane to make an impact Friday against West Ham.