Alexis Sanchez has been the subject of a plethora of transfer rumors of late, and if he is held out for Sunday's match against Bournemouth, Alexandre Lacazette is going to have to step up.
Chelsea are likely to take care of business at home against Leicester City on Saturday, and Andreas Christensen provides some cheap exposure to the Blues' back line.
Tottenham's Harry Kane is likely to be heavily owned on Saturday's seven-game slate, but for fantasy players looking for an alternative, Chelsea's Alvaro Morata fits the mold.
Tottenham are big favorites at home against Everton on Saturday, and fantasy players could turn to Son Heung-Min if they don't want to pay up for Harry Kane.
Willian continues to create chances at a high level, and a home match against Leicester City should allow him to keep it up.
Guingamp have four clean sheets in their last five Ligue 1 matches, and they'll look to do it again Friday against Strasbourg.
Andrew Laird and Jordan Cooper preview Saturday's seven-game fantasy Premier League slate, including whether or not the optimal lineup includes Harry Kane, who is the most expensive player on DraftKings.
Tottenham and Chelsea are the only top-six sides on Saturday's seven-game slate, which means plenty of fantasy players will be considering Harry Kane.
Atletico Madrid are big favorites against third-division Lleida, which means plenty of fantasy players could be stacking them on Tuesday's two-game Copa del Rey slate.
Another two-game slate that includes at least one FA Cup match? Bring it on!
Because who doesn't love a two-game FA Cup slate with staggered start times?
Gonzalo Higuain hasn't scored a Serie A goal since Dec. 1 against Napoli, but he has a pretty good shot at breaking his scoreless streak Saturday against Cagliari.
Manchester City are the biggest favorites on Saturday's four-game FA Cup slate, but if manager Pep Guardiola decides to rotate his lineup, we could see a number of value plays emerge.
Romelu Lukaku is fit again after suffering a nasty head injury, but there's no guarantee he'll get the start for Friday's FA Cup match against Derby County.
Harry Kane did not start Tottenham's match at Swansea City on Tuesday, but he's expected to lead the line Thursday at home against West Ham.
With Manchester City looking to fill the scoring voids left by Gabriel Jesus and Kevin De Bruyne, RotoWire's Schuyler Redpath says fantasy players should turn their attention to Raheem Sterling.
With Harry Kane dealing with an illness and Kevin De Bruyne unlikely to play, fantasy players seem likely to flock toward Sergio Aguero.
Manchester City are heavily favored on Tuesday's four-game slate, and Leroy Sane could be a key piece of the fantasy puzzle.