With Tottenham hosting Manchester United on Wednesday, fantasy managers will likely be turning to Manchester City and Chelsea for their fantasy stars.
All three favorites on Tuesday's Premier League slate are playing away, something that isn't likely to slow down Liverpool's Mohamed Salah.
The oddsmakers are giving Lionel Messi an 83 percent chance of scoring at least one goal against Alaves, but fantasy players will have to sacrifice elsewhere to fit the Barcelona star into their lineups.
Chelsea and Manchester City are both big favorites on Sunday's two-game FA Cup slate, but with many of their regular fantasy stars start?
Landon Donovan is unlikely to play Saturday, but there are still plenty of fantasy points to be had on the four-game Liga MX slate.
Gonzalo Higuain's scoreless streak has reached seven matches in Serie A action will be be able to break through at Chievo on Saturday?
Friday's two-game slate isn't expected to have a ton of goals, which could make accumulators all the more important.
Manchester United are the most popular team on Friday's three-game slate, and their match against fourth-division Yeovil Town could have people targeting Romelu Lukaku and Paul Pogba, if they play.
Tottenham are the biggest favorites on Saturday's four-game slate, but there's no guarantee Christian Eriksen will get a start given the situation.
Real Madrid are heavily favored at home against Leganes in Wednesday's two-game Copa del Rey slate, which could push plenty of fantasy players toward Gareth Bale.
Gonzalo Higuain has gone six consecutive Serie A matches without a goal, but he has a great opportunity to break his stream Monday against Genoa.
Tottenham and Liverpool are the big favorites on the Sunday-Monday two-game slate, which means fantasy players will likely have to decide between Harry Kane and Mohamed Salah.
Riyad Mahrez's fine form of late has Schuyler Redpath looking his way as Leicester host Watford on Saturday.
With Alvaro Morata and Pedro suspended for Saturday's match against Brighton, RotoWire's Schuyler Redpath is expecting Willian to pick up the slack.
Paul Pogba has four assists in his last two games, and he has a great opportunity to keep his fine play going Saturday at Burnley.
Friday's two-game Liga MX slate isn't expected to have a ton of goals, but that doesn't mean there won't be plenty of fantasy points to be had.
Lucas Ocampos has been filling the stat sheet of late, and he'll look to keep it going Friday at Caen.
Manchester City are big favorites on Saturday's seven-game slate, and if fantasy players are going to stack them then Romelu Lukaku becomes a very intriguing GPP differential.