Eden Hazard is likely to get plenty of fantasy attention Sunday, as Chelsea will host a Hull side that has been leaking goals all season.
Zlatan Ibrahimovic has 10 goals in his last 10 games, and he'll head into Saturday's match against Stoke City with the best goal-scoring odds on the slate.
You'll never guess, but Cristiano Ronaldo has a great chance for a big fantasy score this weekend as Real Madrid host Malaga on Saturday.
Romelu Lukaku has scored in three of his last four Premier League matches, and he could be a key captain differential with plenty of players focusing on Arsenal and Chelsea this weekend.
Manchester United's match against Stoke City is likely to push many people toward Zlatan Ibrahimovic for their Togga Perfect XI lineups this weekend.
Arsenal's home match against Burnley pushes a number of Gunners up the rankings, with Alexis Sanchez easily taking the top spot among midfielders.
Saturday's six-game slate is highlighted by the big Manchester City v. Tottenham clash, but there are plenty of fantasy points up for grabs from players like Manchester United's Henrikh Mkhitaryan.
Understanding formations and what certain players are responsible for goes a long way in figuring out where the fantasy points will be on certain slates. Jordan Cooper breaks down the key points to focus on.
Andrew Laird and Mike Gottlieb break down what happened in Gameweek 21 of the Premier League, including big wins from Chelsea and Arsenal, before discussing their new Togga strategy tests about whether scrubs can outperform stars.
Manchester United's Henrikh Mkhitaryan has scored double-digit fantasy points in six of his last seven starts, and the Red Devils will need him to be prolific if they want some points Sunday against Liverpool.
Sunday's two-game slate will make for tricky roster decisions because of no late swap, but Paul Pogba's spot in the starting XI is basically guaranteed.
Olivier Giroud has scored in three straight league games, and a matchup against Swansea City on Saturday should give him a great opportunity to extend his streak.
Andrew Laird and Chris Owen preview the upcoming weekend of Premier League matches, with a number of ugly encounters Saturday before two enticing matchups Sunday.
Mesut Ozil is expected to return from an illness, and he has an excellent matchup against Swansea to produce lots of fantasy points.
Sergio Aguero has the best goal-scoring odds for Sunday's two game slate, though much of the day's talk will be about the huge Manchester United-Liverpool match.
Real Madrid headline Sunday's La Liga slate, though their matchup against Sevilla isn't likely to produce a ton of fantasy points.
Barcelona are heavy favorites Saturday against Las Palmas, and the bookmakers think Lionel Messi's a near sure thing to score at least one goal.
Olivier Giroud has a goal in four straight games in all competitions, and Arsenal's matchup against Swansea City this weekend will likely make him a popular captain option.