Borussia Dortmund will try to overturn a 1-0 deficit at home against Benfica, which means all eyes will be on striker Pierre-Emerick Aubameyang.
Despite playing on the road, Robert Lewandowski comes in with the best goal-scoring odds on the slate, but is he worth paying up for?
Diego Costa got back on the goal-scoring track last weekend, and he'll look to start a streak Monday against West Ham.
Barcelona have a significant deficit to make up when they host Paris Saint-Germain on Wednesday, and if they are going to get close, it'll take a huge performance from Lionel Messi.
Monaco will be without Radamel Falcao for Sunday's home match against Nantes, but they still have plenty of firepower to fill the void.
With Manchester City expected to easily handle Sunderland, many fantasy managers will be pushed in the direction of Kevin De Bruyne.
Saturday's six-game slate is packed with goal-dependent forwards, and Kevin Swanson makes the case for why Leicester's Islam Slimani should be seriously considered by fantasy players.
Andrew Laird and Mike Gottlieb preview the upcoming weekend of Premier League matches, which should include a huge Gylfi Sigurdsson performance and who knows out of Liverpool and Arsenal.
Andrew Laird, Schuyler Redpath and JD Bazzo preview the opening weekend of Major League Soccer, which brings back the age-old fantasy MLS question of whether or not to fade Sebastian Giovinco.
Alexandre Lacazette has scored 22 Ligue 1 goals this season, and he unsurprisingly has the best goal-scoring odds for Friday's two-game slate.
Gylfi Sigurdsson is likely to be highly owned Saturday, but his floor and upside are nearly unmatched, which means fading him could kill a lineup.
Nicolas Lodeiro may be the only player in Major League Soccer who can compete with Sebastian Giovinco's fantasy consistency, and he'll start the new season against one of 2016's worst teams.
Despite playing on the road, Antoine Griezmann has the best anytime goal scorer odds among Wednesday's four teams.
Manchester City and Stoke City have double gameweeks, which means players from both teams move up in our weekly rankings, with Sergio Aguero unsurprisingly at the top of one.
Manchester City will play twice in Gameweek 27, and while many fantasy managers will be looking to Sergio Aguero for the captain's armband, Adam Zdroik says don't forget about Raheem Sterling.
Liverpool v. Arsenal is the highlight match of Saturday's six-game slate, with goals expected after the two sides scored seven in their first meeting this season.
The Timbers are significantly better when they play at Providence Park, and they'll kick off the new season against expansion franchise Minnesota United, putting Diego Valeri firmly in play as a fantasy captain.
Major League Soccer returns this weekend, which means Sebastian Giovinco returns to his regular spot atop one of our weekly positional rankings.