Tuesday's two-game Interleague slate includes four La Liga teams, though without Real Madrid, Barcelona and Atletico Madrid on the schedule, fantasy managers will need to dig deep for fantasy points.
Sadio Mane has scored three goals in his last three starts, and he'll look to extend his streak Monday against Leicester City at the King Power Stadium.
Despite playing away from home, Real Madrid are still heavy favorites Sunday against Villarreal, which means Cristiano Ronaldo should get plenty of fantasy attention.
Harry Kane has four goals in his last two home games, and he has a great opportunity to extend his streak Sunday against Stoke City at White Hart Lane.
Juventus are the biggest favorites on Saturday's four-game interleague slate, which means plenty of fantasy managers will be focusing on Gonzalo Higuain.
Andrew Laird and Chris Owen break down the upcoming weekend of Premier League matches, including whether it's okay to fade Chelsea and which mid-tier midfielders could provide the best value.
With Mario Balotelli suspended and Alassane Plea out with a knee injury, someone will have to step up for Nice as they take on Montpellier at home.
Eden Hazard has been an up-and-down fantasy option this season, but Kevin Swanson explains why the Chelsea midfielder should make an impact Saturday against Swansea City.
Romelu Lukaku bagged a hat trick at Sunderland earlier this season, and he'll get a shot to repeat the feat this weekend at Goodison Park.
Chelsea are the biggest favorites on Saturday's six-game slate, and the bookmakers are thinking Diego Costa will have a big impact on the outcome.
Liverpool will take on lowly Leicester City after the title holders play a midweek Champions League match, setting Sadio Mane up for a big game this weekend, according to Adam Zdroik.
Gonzalo Higuain has scored in nine of his last 10 domestic matches, and he's likely to be involved if Juventus are to take anything out of Wednesday's match at FC Porto.
While he isn't a unanimous top pick, Chelsea's Eden Hazard sits atop the midfield composite ranking as Chelsea host Swansea City this weekend.
Sergio Aguero has his starting job back for Manchester City, and he'll look to make an immediate impact this week against Monaco.
Radamel Falcao has resurrected his career with Monaco this season, and he could be a key piece if they are to upset Manchester City in England on Tuesday.
Sergio Aguero is back at the top of the Man City attack, and he'll head into this week's Champions League slate with the best anytime goal-scoring odds.
Saturday's four-game interleague slate doesn't offer a ton of firepower, though Nice's Mario Balotelli is always capable of putting up a big fantasy score.
Andrew Laird, Schuyler Redpath and JD Bazzo discuss the changes in MLS Fantasy Manager for the upcoming season, including unlimited transfers, and which new players to the league could make an immediate fantasy impact.