NFL Picks: 
Carolina Panthers vs. 
San Francisco 49ers : Odds, Picks, and Predictions for MNF Week 12
The Carolina Panthers (6-5) travel to San Francisco to take on the 49ers (7-4) in an NFC matchup on Monday Night Football. The Panthers are coming off a huge divisional road win against the Falcons, while the 49ers are off a road divisional win of their own against the Cardinals.
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Carolina Panthers vs. San Francisco 49ers Betting Odds
- Panthers +7.5 (DraftKings +115) / 49ers -7.0 (Bet365 -120)
- Panthers ML (FanDuel +320) / 49ers ML (Bet365 -370)
- Total OVER 49.5 (DraftKings -110) / UNDER 49.5 (DraftKings -110)
- Panthers total points: Over 20.5 (DraftKings -108) / Under 20.5 (DraftKings -112)
- 49ers total points: Over 29.5 (FanDuel -111) / Under 30.5 (Caesars SportsBook -134)
- First-half spread: Panthers +4.0 (Bet365 +100) / 49ers -4.5 (DraftKings -105)
- First-half total: Over 24.5 (DraftKings -108) / Under 24.5 (DraftKings -112)
- First-half team total:
- Panthers Over/Under 9.5 (BetRivers -148/+120)
- 49ers Over/Under 13.5 (BetRivers -139/+112)
The 49ers opened as 7.0-point home favorites, but it reopened at -6.0 on November 11th. It moved to -6.5 on the 15th and back to -7.0 on the 17th.
The total opened at 46.5 and reopened on November 11th at 45.5. Both the Panthers and 49ers put up huge offensive totals last week and it moved the total significantly. it went to 47 on the 16th, and continued to climb 0.5 points each day to peak at 49.5.
The majority of the bets (62%) have come in on the 49ers, but the handle is at 55% in favor of the 49ers. This reflects that some "sharp" money is coming in on Carolina.
The total has 60 percent of bets on the UNDER, but 67 percent of the money. The moneyline is on the Panthers at 95% of the bets and 95% of the money.
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Key Injuries
Panthers - OL Cade Mays (O), LB Trevin Wallace (O), LB Christian Robinson (O), OL Brady Christensen (O)
49ers - DE Robert Beal Jr (D), LB Luke Gifford (Q), LB Tatum Bethune (O), WR Brandon Aiyuk (O), DE Nick Bosa (O)
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Panthers vs. 49ers Betting Picks
Both teams are coming off a bye or extended rest, and both lost their last game, so I look for some fireworks on Monday night between the Panthers and the 49ers.
BETTING TRENDS
- Carolina is 5-2 ATS in its last 7 games.
- The total has gone OVER in 12 of Carolina's last 18 games.
- Carolina is 5-2 SU in its last 7 games.
- Carolina is 14-4 ATS in its last 18 games against San Francisco.
- San Francisco is 7-13 ATS in its last 20 games.
- The total has gone OVER in 6 of San Francisco's last 8 games.
- The total has gone OVER in 15 of San Francisco's last 20 games against Carolina.
- San Francisco is 1-5 ATS in its last 6 games at home.
- The 49ers as -3.0 to -8.0 home favorites
- 3-7 SU, 3-7 SU, 7-3 O/U last 10
- 9-11 SU, 8-12 ATS, 10-5 O/U last 20
- 14-16 SU, 11-19 ATS, 21-9 O/U last 30
- The Panthers as +3.0 to +8.0 road dogs
- 3-7 SU, 4-6 ATS, 7-3 O/U
- 5-15 SU, 9-11 ATS, 13-7 O/U
- 7-23 SU, 13-17 ATS, 19-11 O/U
Panthers vs. 49ers Best Bets
- Panthers/49ers OVER 49.5 points for 1 unit (DraftKings -110)
- Bryce Young OVER 204.5 passing yards for 1 unit (FanDuel -114)
- Panthers +7.5 for 1 unit (DraftKings -115)
- George Kittle OVER 4.5 receptions (DraftKings -133)
Panthers vs. 49ers Predictions
If this were a Sunday game, I would put more stock into the Panthers having to travel all the way west, but with it being on Monday night, that does not have as much of an impact on them.
The 49ers' defense is not what it used to b,e and the Panthers' offense has come alive in recent weeks.
The 49ers are a public favorite this week, and their recent trends in this spot are not favorable. I will lean on the Panthers to keep the game close in a high-scoring affair.
