There are five road favorites during Saturday's seven-game slate, with Arsenal as the top one against Swansea at the Liberty Stadium.
With Barcelona on the slate, fantasy owners are presented with the big question of who to choose between Lionel Messi, Neymar and Luis Suarez.
Real Madrid are heavy favorites in their first match after the winter break, which means fantasy players will be looking squarely toward Cristiano Ronaldo.
In his debut column for RotoWire, Jordan Cooper breaks down the key differences between small and large slates for DFS soccer contests and what players should focus on when they prepare their lineups.
Alexis Sanchez hasn't scored in two straight games, but he's taken 17 shots over that span and could certainly break through Tuesday against Bournemouth.
Fresh off his incredible scorpion kick Sunday, Olivier Giroud will try to find the back of the net for the third time in three games Tuesday against Bournemouth.
Arsenal are the top dogs on Tuesday's three-game slate, though there are a number of fantasy options who could provide top value.
Paul Pogba has scored at least 40 fantasy points in three of his last four games, and a Monday matchup against West Ham should allow him to continue his solid form.
James Milner has scored double-digit fantasy points in nine consecutive games, and he has a great opportunity to extend the streak Monday at Sunderland.
Tottenham and Arsenal have fairly easy matchups during Sunday's two-game Premier League slate, and fantasy managers looking to pay up in defense should turn to Danny Rose.
Kevin De Bruyne is likely to be a popular fantasy option during Monday's five-game slate, as Man City will look to bounce back at home against Burnley.
Arsenal and Tottenham are heavy favorites on Sunday's two-game slate, which means plenty of fantasy players will be looking to Alexis Sanchez.
Henrikh Mkhitaryan is finally finding his form with Manchester United, and a home match against Middlesbrough on Saturday puts him in a great spot for fantasy owners.
Sergio Aguero returns after his four-match ban, and Kevin Swanson likes the Argentine as a solid upper-tier option who comes in cheaper than both Diego Costa and Zlatan Ibrahimovic.
Chelsea are big favorites playing at home against Stoke City, which means Eden Hazard is likely to get plenty of fantasy attention.
Harry Kane has decent goal-scoring odds against Southampton on Wednesday, but there's another team that may be worth stacking on a short slate.
Manchester United are heavy favorites on Boxing Day, giving David De Gea a good chance at the win and clean sheet.
Manchester City's attack has understandably fallen off a bit without Sergio Aguero, but Leroy Sane may be the one to get them back on track Monday at Hull City.