Four of the top six teams in the table aren't on Saturday's main slate, but with Spurs taking on Boro at White Hart Lane, Harry Kane figures to draw plenty of attention from fantasy players.
Another Friday match means Marseille is back on the interleague slate, forcing fantasy players to decide whether Bafetimbi Gomis is worth the investment again.
With Manchester United expected to take care of business against Hull City on Wednesday, Henrikh Mkhitaryan could be in for a big game.
With two of the top three most expensive midfielders ineligible, Man City's Kevin De Bruyne is likely to be heavily owned Wednesday.
Manchester United are big favorites facing Hull at home, which means Zlatan Ibrahimovic should get plenty of attention from fantasy players.
Sunderland come into Tuesday's match without three starting defenders, which means Tottenham's Harry Kane could have a field day.
Sunday's three-game interleague slate includes two heavy favorites, including Real Madrid, which means fantasy players will have to decide whether or not to invest heavily into Cristiano Ronaldo.
Dele Alli has scored eight goals in his last six league games, but is he the Spurs attacker that fantasy players should rely on Tuesday?
Arsenal players are likely to get plenty of fantasy attention for Tuesday's slate, as they'll face off against a Watford side that's allowed multiple goals in three of their last four league matches.
Atletico Madrid are the biggest favorites on Saturday's three-game slate, which does not include Real Madrid or Barcelona, putting Antoine Griezmann firmly in consideration for fantasy players.
Bafetimbi Gomis has the best goal-scoring odds for Friday's three-game interleague slate, which includes matches from La Liga, Ligue 1 and the FA Cup.
Getting a piece of the Manchester United attack will be important when they line up against Stoke City, putting Henrikh Mkhitaryan firmly in play.
Eden Hazard is likely to get plenty of fantasy attention Sunday, as Chelsea will host a Hull side that has been leaking goals all season.
Zlatan Ibrahimovic has 10 goals in his last 10 games, and he'll head into Saturday's match against Stoke City with the best goal-scoring odds on the slate.
You'll never guess, but Cristiano Ronaldo has a great chance for a big fantasy score this weekend as Real Madrid host Malaga on Saturday.
Saturday's six-game slate is highlighted by the big Manchester City v. Tottenham clash, but there are plenty of fantasy points up for grabs from players like Manchester United's Henrikh Mkhitaryan.
Manchester United's Henrikh Mkhitaryan has scored double-digit fantasy points in six of his last seven starts, and the Red Devils will need him to be prolific if they want some points Sunday against Liverpool.
Sunday's two-game slate will make for tricky roster decisions because of no late swap, but Paul Pogba's spot in the starting XI is basically guaranteed.