With Barcelona having to make up a four-goal deficit at home against Paris Saint-Germain, Lionel Messi is likely to be firing shots all night.
Borussia Dortmund will try to overturn a 1-0 deficit at home against Benfica, which means all eyes will be on striker Pierre-Emerick Aubameyang.
Despite playing on the road, Robert Lewandowski comes in with the best goal-scoring odds on the slate, but is he worth paying up for?
Diego Costa got back on the goal-scoring track last weekend, and he'll look to start a streak Monday against West Ham.
Barcelona have a significant deficit to make up when they host Paris Saint-Germain on Wednesday, and if they are going to get close, it'll take a huge performance from Lionel Messi.
Monaco will be without Radamel Falcao for Sunday's home match against Nantes, but they still have plenty of firepower to fill the void.
With Manchester City expected to easily handle Sunderland, many fantasy managers will be pushed in the direction of Kevin De Bruyne.
Saturday's six-game slate is packed with goal-dependent forwards, and Kevin Swanson makes the case for why Leicester's Islam Slimani should be seriously considered by fantasy players.
Alexandre Lacazette has scored 22 Ligue 1 goals this season, and he unsurprisingly has the best goal-scoring odds for Friday's two-game slate.
Gylfi Sigurdsson is likely to be highly owned Saturday, but his floor and upside are nearly unmatched, which means fading him could kill a lineup.
Nicolas Lodeiro may be the only player in Major League Soccer who can compete with Sebastian Giovinco's fantasy consistency, and he'll start the new season against one of 2016's worst teams.
Despite playing on the road, Antoine Griezmann has the best anytime goal scorer odds among Wednesday's four teams.
Liverpool v. Arsenal is the highlight match of Saturday's six-game slate, with goals expected after the two sides scored seven in their first meeting this season.
Lionel Messi is always a popular fantasy option, and his ownership could be even higher Wednesday because oddsmakers are giving him an 80 percent chance to score at least once.
Tuesday's two-game Interleague slate includes four La Liga teams, though without Real Madrid, Barcelona and Atletico Madrid on the schedule, fantasy managers will need to dig deep for fantasy points.
Sadio Mane has scored three goals in his last three starts, and he'll look to extend his streak Monday against Leicester City at the King Power Stadium.
Despite playing away from home, Real Madrid are still heavy favorites Sunday against Villarreal, which means Cristiano Ronaldo should get plenty of fantasy attention.
Harry Kane has four goals in his last two home games, and he has a great opportunity to extend his streak Sunday against Stoke City at White Hart Lane.