Brazil have already qualified for the World Cup, but fantasy managers should still be able to rely on Neymar if he gets a start against Ecuador.
Belgium will take on lowly Gibraltar on Thursday, and Romelu Lukaku could have a historic fantasy performance.
There are three gigantic favorites on Wednesday's five-game UEFA World Cup qualifying slate, with Portugal's Cristiano Ronaldo one of the elite stars in action.
Argentina have struggled in World Cup qualifying of late, and they'll need a big performance in a tough matchup in Uruguay from Lionel Messi.
Evan Morter picks the Saturday MLS slate on DraftKings as Miguel Almiron has a good chance against Philadelphia to bust out of his slump.
Romelu Lukaku is the top forward option on Saturday's five-game slate, and Kevin Swanson makes the case for fantasy players to pair him with Christian Benteke.
Lots of fantasy players will be drawn to Henrikh Mkhitaryan on Saturday, but RotoWire's Andrew Laird explains why the Man United midfielder isn't as safe as he seems.
Saturday's five-game slate leaves plenty to be desired in terms of star power, which means Romelu Lukaku is likely to draw plenty of attention from fantasy players.
Sebastian Giovinco is going to be a very popular pick on Wednesday's main MLS slate, and Evan Morter has a number of players to pair with the Atomic Ant.
The final participants in the Champions League group stage will be decided Wednesday, with Sadio Mane looking to solidify Liverpool's spot in the prestigious tournament.
Faouzi Ghoulam is one of the most expensive players at his position on Tuesday's four-game slate, but Schuyler Redpath explains why fantasy managers should still target the Napoli defender.
Most fantasy lineups Sunday will be packed with players from NYC FC and Seattle, with Nicolas Lodeiro one of the safer choices, according to Evan Morter.
Despite playing on the road, RotoWire's JD Bazzo explains why the Crew's Justin Meram should get plenty of fantasy consideration Saturday against Orlando City.
Riyad Mahrez picked up an assist in Leicester's opening match of the season last Friday at the Emirates, and he'll look to make an even bigger impact Saturday at home against Brighton.
Arsenal's attacking players are likely to be popular fantasy options Saturday, with Kevin Swanson already liking what he sees out of Gunners striker Alexandre Lacazette.
Alexandre Lacazette scored just a few minutes into his Premier League debut last week, and bookmakers are giving him a solid chance of starting a streak Saturday at Stoke City.
Napoli's Dries Mertens was one of the best goal scorers in Serie A last season, and Schuyler Redpath explains why he shouldn't be ignored despite his high price Wednesday against Nice.
With Philippe Coutinho and Daniel Sturridge ruled out, RotoWire's Schuyler Redpath is looking for Roberto Firmino to shoulder the Liverpool attack against his former club.