Netherlands, France and Switzerland are all big favorites on Saturday's late four-game slate, and Antoine Griezmann comes in with the best anytime goal scoring odds.
The United States needs a win at home against Panama on Friday to keep their World Cup hopes alive, and they'll be looking to Christian Pulisic to make an impact.
Spain have a very easy match at home against Albania to solidify their spot in the 2018 World Cup, and bookmakers are expecting plenty of goals.
There are a number of players away on international duty this weekend, but Sacha Kljestan is still around to help the Red Bulls solidify their postseason spot.
Argentina has had a tough path to World Cup qualification, but there is a chance they could book their ticket to Russia if they beat Peru on Thursday and get help elsewhere.
England are heavy favorites as they host Slovenia on Thursday, and bookmakers are expecting Harry Kane to make an impact.
Arsenal are heavy favorites at home against Brighton on Sunday, and the bookmakers are expecting a solid performance from Alexandre Lacazette.
David Villa looks set to start for NYC FC on Saturday against the Fire, but RotoWire's JD Bazzo explains why that makes another NYC attacker more attractive than paying up for Villa.
Many people will be focusing on getting Romelu Lukaku into their lineups, but Kevin Swanson says not to forget about midfielder Henrikh Mkhitaryan.
Manchester United are the biggest favorites on the slate, and Romelu Lukaku is surely to be highly owned in cash games and tournaments because of his goal-scoring odds.
Romelu Lukaku's hot streak continued in Wednesday's Champions League match against CSKA Moscow, and he'll look to add to his goal total Saturday against Crystal Palace.
Sacha Kljestan hasn't had the strongest season, but Evan Morter is expecting a vintage performance Wednesday against D.C. United.
Paulo Dybala has 10 goals in six Serie A matches this season, and his share of set pieces makes him one of the best fantasy options available on Wednesday's seven-game slate.
Miralem Pjanic's role for Juventus allows him to pick up fantasy points all over the pitch, giving him a solid floor Wednesday against Olympiacos.
Juventus are strong favorites at home against Olympiacos on Wednesday, which means plenty of fantasy managers could be turning to Gonzalo Higuain.
Traveling to Cyprus to take on Apoel Nicosia should be no problem for Spurs, who will once again rely on Harry Kane to lead the attack.
Napoli are big favorites over Feyenoord on Tuesday's eight-game slate, and while Schuyler Redpath says you should load up, finding the right values to pair with them will be key.
Radamel Falcao has 11 goals in seven Ligue 1 matches this season, and he'll look to bag his first one in the Champions League Tuesday against Porto.