The United States can book their ticket to Russia with a result at Trinidad & Tobago on Tuesday, and they come into the three-game slate as the heaviest favorites.
Argentina need a result in Ecuador to book their ticket to the World Cup, and they'll be relying heavily on Lionel Messi to get them there.
Many of the top teams on Tuesday's slate will likely rotate their lineups having already qualified for the World Cup, though even their backups may not be that cheap.
A few teams on Monday's five-game slate have already qualified for the 2018 World Cup, which means we could see some serious squad rotation.
Germany have already booked their ticket to the 2018 World Cup in Russia, which means we could see some significant lineup rotation Sunday against Azerbaijan.
Slovakia are the biggest favorites on Sunday's early six-game slate, but Poland, England and Denmark are also expected to dominate their matches.
The Red Bulls control their postseason destiny, and they'll look for Sacha Kljestan to lead them to victory Saturday against Vancouver.
While Belgium have plenty of players who fantasy managers love to pick, they are far from the biggest favorites on Saturday's early four-game slate.
Netherlands, France and Switzerland are all big favorites on Saturday's late four-game slate, and Antoine Griezmann comes in with the best anytime goal scoring odds.
The United States needs a win at home against Panama on Friday to keep their World Cup hopes alive, and they'll be looking to Christian Pulisic to make an impact.
Spain have a very easy match at home against Albania to solidify their spot in the 2018 World Cup, and bookmakers are expecting plenty of goals.
There are a number of players away on international duty this weekend, but Sacha Kljestan is still around to help the Red Bulls solidify their postseason spot.
Argentina has had a tough path to World Cup qualification, but there is a chance they could book their ticket to Russia if they beat Peru on Thursday and get help elsewhere.
England are heavy favorites as they host Slovenia on Thursday, and bookmakers are expecting Harry Kane to make an impact.
Arsenal are heavy favorites at home against Brighton on Sunday, and the bookmakers are expecting a solid performance from Alexandre Lacazette.
David Villa looks set to start for NYC FC on Saturday against the Fire, but RotoWire's JD Bazzo explains why that makes another NYC attacker more attractive than paying up for Villa.
Many people will be focusing on getting Romelu Lukaku into their lineups, but Kevin Swanson says not to forget about midfielder Henrikh Mkhitaryan.
Manchester United are the biggest favorites on the slate, and Romelu Lukaku is surely to be highly owned in cash games and tournaments because of his goal-scoring odds.