Edin Dzeko has scored seven goals in his last five starts for Roma, but he may find it tough to extend his scoring streak to six games Saturday against Napoli.
Diego Valeri has 10 goals in his last 10 games, and he'll look to get closer to locking up the golden boot at home against D.C. United on Sunday.
Sunday's two-game slate features only one team in the top half of the table.
NYC FC will continue their quest for a top-two spot in the Eastern Conference on Saturday against the Revs, and they'll need David Villa to make a big impact.
Manchester City and Tottenham are likely to get plenty of attention from fantasy players Saturday, but Kevin Swanson reminds us not to forget about Chelsea.
Fantasy players are likely to want lots of exposure to Tottenham and Manchester City on Saturday, which means they'll need plenty of value plays to pair with the high-priced attackers.
Tottenham are heavily favored at home against Bournemouth on Saturday, and midfielder Christian Eriksen is likely to have a big impact.
Tottenham aren't the biggest favorites on Saturday's six-game slate, but striker Harry Kane has the highest anytime goal-scoring odds.
The United States can book their ticket to Russia with a result at Trinidad & Tobago on Tuesday, and they come into the three-game slate as the heaviest favorites.
Argentina need a result in Ecuador to book their ticket to the World Cup, and they'll be relying heavily on Lionel Messi to get them there.
Many of the top teams on Tuesday's slate will likely rotate their lineups having already qualified for the World Cup, though even their backups may not be that cheap.
A few teams on Monday's five-game slate have already qualified for the 2018 World Cup, which means we could see some serious squad rotation.
Germany have already booked their ticket to the 2018 World Cup in Russia, which means we could see some significant lineup rotation Sunday against Azerbaijan.
Slovakia are the biggest favorites on Sunday's early six-game slate, but Poland, England and Denmark are also expected to dominate their matches.
The Red Bulls control their postseason destiny, and they'll look for Sacha Kljestan to lead them to victory Saturday against Vancouver.
While Belgium have plenty of players who fantasy managers love to pick, they are far from the biggest favorites on Saturday's early four-game slate.
Netherlands, France and Switzerland are all big favorites on Saturday's late four-game slate, and Antoine Griezmann comes in with the best anytime goal scoring odds.
The United States needs a win at home against Panama on Friday to keep their World Cup hopes alive, and they'll be looking to Christian Pulisic to make an impact.