There aren't expected to be many goals during Saturday's five-game slate, which means many fantasy players could be paying up for Mohamed Salah.
James Milner has been a dominant fantasy option of late, but is his rising price worth it Saturday against West Ham?
Mohamed Salah has four goals in his last four matches in all competitions, and he'll look to extend his streak of fine play Saturday at West Ham.
With the top five teams in the table playing Sunday, fantasy players could be looking to stack Liverpool as they face off against West Ham at London Stadium.
After a disappointing 1-1 draw in Cyprus two weeks ago, Borussia Dortmund are expected to come out swinging at home against Apoel Nicosia on Wednesday.
Liverpool are big favorites at home against Maribor on Wednesday, and their attacking group is likely to get plenty of attention from fantasy players.
Atletico Madrid need a big performance out of Antoine Griezmann against Qarabag on Tuesday if they want to have a realistic shot at advancing to the group stage.
Despite possibly being without Philippe Coutinho, Liverpool are the biggest favorites on Wednesday's Champions League slate, and Mohamed Salah could have a major impact.
Paris Saint-Germain's home match against Anderlecht will have plenty of fantasy players targeting Neymar, who returns after serving a one-match domestic ban.
Fantasy players are likely to flock to Neymar for Tuesday's eight-game Champions League slate, with PSG heavily favored against Anderlecht.
Inter Milan are the biggest favorites on Monday's four-game slate, and the bookmakers are expecting fireworks from Mauro Icardi.
Florian Thauvin is on a roll for Marseille, and he'll look to keep it going Sunday against Lille.
Riyad Mahrez has been a disappointing fantasy option for much of this season. Could his breakout game come Sunday at home against Everton?
Liverpool, Arsenal and Manchester City are the three biggest favorites on Saturday's six-game slate, but getting a piece from each might be too tough without punting at least one spot.
Liverpool will look to bounce back after getting thrashed by Tottenham last weekend, which means fantasy owners will have to decide which attackers to prioritize.
Man City are likely to dominate possession during Saturday's match at West Brom, which will make plenty of their players popular fantasy options on The Six.
Despite playing away at West Brom, Manchester City are still expected to produce plenty of fantasy fireworks.
Juventus are the biggest favorites on Wednesday's five-game Serie A slate, but fantasy managers probably won't want to stack them too heavily because of the other options available.