Napoli need a win and help elsewhere to qualify for the knockout rounds of the Champions League, and they'll look for Lorenzo Insigne to make a big impact.
Roma are the biggest favorites with the highest implied goal odds among Tuesday's eight Champions League matches, and they'll rely on Edin Dzeko to lead them to the round of 16.
Paulo Dybala has yet to find the scoresheet during Champions League play, but Schuyler Redpath is expecting a breakout performance Tuesday at Olympiacos.
Andrew Laird and Jordan Cooper review their DraftKings cash lineups from this past Saturday's Premier League slate before jumping in to preview Tuesday's eight Champions League matches.
Roma will book their place in the knockout rounds with a win against Qarabag on Tuesday, and they'll rely on Edin Dzeko to put them ahead.
Sunday's three-game interleague slate doesn't have any dominant favorites, so fantasy players could look to rack up peripheral stats with players like Jordan Amavi.
With Manchester City one of four teams on Sunday's two-game slate, fantasy managers will have a tough time fitting in as many Citizens as possible.
Mohamed Salah has been on a tear of late, and with Liverpool facing Brighton on Saturday, he's likely to be a very popular fantasy option.
Harry Kane is likely to draw plenty of attention as Spurs look to bounce back at Watford on Saturday, but a few of his teammates may be better fantasy options.
Playing at home against Swansea City is always a place to look for fantasy value, and Eric Maxim Choupo-Moting sticks out among the Stoke City attackers.
With Tottenham possibly rotating their fullbacks after Serge Aurier and Danny Rose started during the midweek, Kieran Trippier could regain his spot in the starting XI at Watford.
Andrew Laird and Jordan Cooper preview Saturday's seven-game daily fantasy Premier League slate, including whether we can finally trust Gylfi Sigurdsson again and if paying up for the Liverpool forwards is worth it.
Two teams have better win odds than Tottenham on Saturday's seven-game slate, but no one has better anytime goal scoring odds than Harry Kane.
Liverpool could rotate a bit after last weekend's match against Chelsea, but if James Milner keeps his spot in the starting XI, he could make a solid play on The Six.
Manchester City have a number of very good fantasy options, but Schuyler Redpath sees one who could really pay off in GPPs on Wednesday.
Manchester City are big favorites at home against Southampton on Wednesday, but do fantasy owners need to pay up for Kevin De Bruyne?
Wednesday's six-game slate includes three overwhelming favorites and Liverpool away to Stoke City, which means fantasy owners will have to find creative ways to roster the likes of Mohamed Salah.
Manchester United and Tottenham are the big teams on Tuesday's four-game slate, but is it worth paying up for Harry Kane?