We're oh-so-close to the end of the MLB regular season. Wednesday has nine games on the DFS slate starting at 7:05 p.m. EDT or later. Mercifully, the Tigers aren't playing in that time frame, so I don't have to think about them within these parameters. I did manage to get a complaint in about the Tigers, though! Onto the MLB DFS lineup recommendations.
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Pitching
Jacob deGrom, TEX vs. MIN ($9,500): DeGrom is going to get to 30 starts! What a time to be alive. Also, he's pitched well on the season and has a 2.39 ERA at home. The Twins and Rangers are actually battling to get out of the bottom 10 in runs scored, but even if deGrom may struggle to get the run support for an easy win, he should have a good game on the mound.
Luis Castillo, SEA vs. COL ($8,600): In each of Castillo's last three starts he's gone six innings, and in those 18 innings he's allowed a total of two runs. Could he do that again? In this matchup, and in Seattle? You bet! Castillo has a 2.71 ERA at home, and the Rockies are 29th in runs scored and last in team OBP.
Yusei Kikuchi, LAA vs. KAN ($7,600): It's been a classic Jekyll-and-Hyde scenario for Kikuchi, done in the home/road sense of things. The lefty has a 5.04 ERA on the road, which is quite poor, but a 3.00 ERA at home. This game is in Anaheim (which is famously not Los Angeles) and the Royals are going to finish in the bottom five in runs scored.
Top Targets
Odds are the White Sox will be going with a bullpen game Wednesday, so I wanted a Yankees righty. Lefties tend to have bigger splits based on the handedness of the pitcher, after all. Since 2023, Giancarlo Stanton ($3,500) has slugged .466 against lefties and .481 against righties. Plus, in that same time frame he has slugged .528 at Yankee Stadium.
For the second season in a row Matt Chapman ($3,300) is likely to have 20 homers and double-digit stolen bases. However, owing to injuries he's only played in 125 games, so he's done his damage with less opportunity. The third baseman has slugged .455 against his fellow righties as well. It's been a tough season for Sonny Gray, even with his stellar K/BB rate. He has a 5.11 ERA on the road, and he also has let righties hit .280 against him.
Bargain Bats
Over the last three weeks, Jorge Polanco ($3,000) has an 1.027 OPS. He's also been strong at home, where he has an .887 OPS. Tanner Gordon has a career 6.86 ERA, but that's not about Coors Field, or at least not fully. His career road ERA is actually 8.75.
When Wyatt Langford tweaked his side (again) Tuesday, it became about finding any viable Ranger who is healthy and might have some upside. Enter Joc Pederson ($2,800). He is one-dimensional, but his chances of hitting a homer are as good as any Ranger. Just last year the southpaw slugged .531 against righties, and he's had several 20-homer seasons even though he's mostly unplayable against lefties. Taj Bradley is a righty, and over his last six starts he has an 8.67 ERA and 2.0 HR/9 rate.
Stacks to Consider
Astros at Athletics (J.T. Ginn): Isaac Paredes ($3,100), Zach Cole ($2,700), Jesus Sanchez ($2,600)
If only Yordan Alvarez was healthy. Ginn has a 5.98 ERA and 2.5 HR/9 rate at home. He's also allowed lefties to hit .332 against him in his career. Unfortunately, the Astros are not known for their left-handed hitters. Fortunately, I was able to get two southpaws in this stack, and then threw a righty with some power into the mix.
Paredes is the righty with power. He's hit 20 homers in 98 games this season. Parades also has an .845 OPS against his fellow righties, so that's encouraging. In 15 games at Triple-A, Cole had an 1.204 OPS. When Alvarez went down, Cole was called up to step in as a lefty bat. In 10 games, he's hit three homers. For the second season in a row, Sanchez has double-digit homers and stolen bases. Since 2023, he's slugged .450 against righties as well.
Red Sox at Blue Jays (Max Scherzer): Trevor Story ($3,700), Nathaniel Lowe ($2,800), Wilyer Abreu ($2,600)
Scherzer is a Hall of Famer, but he's also 41, and so perhaps it is not surprising he has a 5.06 ERA on the season. This is built upon a collapse here down the stretch. Over his last five starts Scherzer has a 9.45 ERA. Given that "Mad Max" is a righty, and given that lefties have hit twice as many homers against him as righties in 2025, I have two southpaws in this stack.
Story is a righty, but he's hit .266 against his fellow righties, and one of his calling cards is stealing bases. That's generally easier against right-handed pitchers. On the year, the shortstop has 25 homers and 31 swiped bags. Lowe has been better since joining the Red Sox, and he has a hit in six consecutive games. He also has a .782 OPS versus righties over the last three seasons. Abreu only just returned from injury, but he's stepping into a good scenario for him. In addition to his .497 slugging percentage versus righties, he has slugged .481 on the road.
