David Njoku could see a big target count, especially if Patrick Surtain denies targets to wideout Jerry Jeudy.
The Bills should have at least one productive running back Sunday, and James Cook has scored touchdowns at a rapid rate in 2024.
Isiah Pacheco makes his return Friday, but it's not clear how much usage he'll get in his first game back.
Justin Herbert could post productive fantasy numbers Monday, especially if he keeps running as often as he has in the past month.
The Eagles need to get A.J. Brown the ball Sunday night, and there might not be much the Rams can do to slow him.
At 6-4 the Texans might need to fully unleash Nico Collins in his first game back, because they can't afford to take a fifth loss at the hands of Dallas.
The Chargers might not throw much by design, but if the Bengals offense scores quickly then Ladd McConkey might be busy as the Chargers try to keep pace.
Kyren Williams is likely in line for a big game against a weak Miami run defense.
Amon-Ra St. Brown could be productive against a Houston defense that doesn't move around its corners, allowing Detroit to avoid Derek Stingley.
Baker Mayfield has thrown seven interceptions in his last three games, and without his top two wideouts he could throw a few more interceptions at Arrowhead on Monday.
Michael Pittman has struggled through a back injury, but if the injury has improved then Pittman could get back on track with Joe Flacco at quarterback.
The arrival of Russell Wilson lifts up the Pittsburgh passing game, but it also makes life easier for Najee Harris, who could keep rolling Monday.
The 49ers need Jordan Mason to carry the offense Sunday, and he's likely prepared to do so.
The Cardinals must get the ball to Marvin Harrison more, and the Chargers' beat-up corner rotation might provide a get-right game Monday.
Secondary Ravens pass catchers like Rashod Bateman might get open against Tampa Bay's weak cornerback rotation.
The Steelers hope Russell Wilson can improve the Pittsburgh passing game, but the fading veteran steps into a challenging situation Sunday night.
If the Jets really mean to commit to the ground game then they'll have to prove it by feeding Breece Hall against the Bills on Monday.
Tyrone Tracy showed up big for the Giants in Week 5, and they'll need to call on him again with Devin Singletary (groin) unavailable against Cincinnati on Sunday night.
Derek Carr has a career average of just 6.3 yards per pass against the Chiefs, and now he needs to play at Arrowhead with an interior offensive line decimated by injury.
Dak Prescott is without Brandin Cooks against a dangerous Pittsburgh defense, but he should need to throw the ball often given Dallas' rushing struggles.
Despite three weeks of struggles to open the 2024 season, Jared Goff is in a good bounce-back spot Monday night.
The Miami run defense is much more inviting than any Tony Pollard has seen in his first three games with Tennessee.
Derrick Henry finally got rolling in Week 3, but he faces a much tougher defense Sunday night than the Dallas one from Week 3.
The Commanders are heavy road underdogs, but Brian Robinson should still be busy against a beat-up and questionable Bengals run defense.
Josh Allen could do big damage Monday, but it's also not clear if the Bills will need to ask much of him against a sinking Jaguars squad.
With both offenses struggling through two weeks it's likely crucial to pursue Bijan Robinson's assured usage in single-game lineups between Atlanta and Kansas City on Sunday night.
With A.J. Brown (hamstring) unavailable, DeVonta Smith becomes extremely difficult to fade against Atlanta on Monday.
C.J. Stroud is generally stronger at home than on the road, but the Bears defense is strong enough to raise the difficulty level Sunday night.
There's both hope and apprehension for the Jets offense as Aaron Rodgers returns from last year's Achilles' tendon tear on the road and against a dangerous 49ers defense.
Jahmyr Gibbs is reportedly over his hamstring injury, setting up for a monster box score against the Aaron Donald-less Rams on Sunday night.