Injury hotspots for Week 8 include the Cowboys' secondary, Bears' secondary, Giants' secondary, Bucs' skill-position players and Texans' wide receivers.
Note: Article edited Saturday, following major injury news on Lamar Jackson and others.
Below you'll find four different categories, with our lists including key offensive linemen and defensive players whose absences might impact fantasy decisions. The bottom section, for potential game-day decisions, is sorted by kickoff times. It can be used as a checklist/cheatsheet for Sunday morning and afternoon when inactives come out and we need to adjust lineups. Before we get to the 'questionable' players, let's see who's definitely in and who's definitely out...
Good to Go 💯
QB Baker Mayfield (knee)
RB Josh Jacobs (calf)
RB D'Andre Swift (groin)
RB Alvin Kamara (ankle)
WR Chris Olave (ankle)
WRs Terry McLaurin (quad) & Deebo Samuel (heel)
WR Jaylen Waddle (hamstring/rest)
WR DJ Moore (groin)
WR Stefon Diggs (chest)
WR Emeka Egbuka (hamstring)
WR Josh Downs (concussion)
WR Jerry Jeudy (knee)
WR Darius Slayton (hamstring)
WR Curtis Samuel (ribs)
TE Dalton Schultz (back/shoulder)
TE Juwan Johnson (neck)
TE Tanner Hudson (concussion)
#Commanders WRs Terry McLaurin and Deebo Samuel Sr. were full participants in practice again today and are on track to return to action Monday night at Kansas City.
— Tom Pelissero (@TomPelissero) October 24, 2025
Ruled Out/Doubtful 🚑
Out/Doubtful/IR
QB Jayden Daniels (hamstring)
QB Bryce Young (D - ankle)
QB Brock Purdy (toe)
QB Lamar Jackson (hamstring)
QB Tyrod Taylor (knee)
RB Bucky Irving (shoulder/foot)
RB Roschon Johnson (back)
RB Kendre Miller (IR - ACL tear)
WRs Mike Evans (IR - collarbone) & Chris Godwin (fibula)
WR Ricky Pearsall (knee)
WRs Nico Collins (concussion) & Christian Kirk (hamstring)
WRs Garrett Wilson (knee) & Josh Reynolds (hip)
WR A.J. Brown (hamstring)
WRs Calvin Ridley (hamstring) & Bryce Oliver (knee)
WR Joshua Palmer (knee)
WR Dontayvion Wicks (calf)
WR Scotty Miller (finger)
TE Cole Kmet (back)
TEs Darren Waller (pec) + Julian Hill (ankle)
Potential Workload Beneficiaries (From Injuries Above)
QB Marcus Mariota
QB Andy Dalton
QB Mac Jones
QB Tyler Huntley
QB Justin Fields
RBs Rachaad White & Sean Tucker
RBs Alvin Kamara & Devin Neal
WRs Emeka Egbuka, Tez Johnson & Sterling Shepard
WR Kendrick Bourne
WRs Jaylin Noel, Jayden Higgins & Xavier Hutchinson
WRs Josh Reynolds (Q), Arian Smith, Allen Lazard & Tyler Johnson
WRs DeVonta Smith, Jahan Dotson & John Metchie
WRs Elic Ayomanor, Chimere Dike & Van Jefferson
WRs Keon Coleman & Curtis Samuel
WRs Matthew Golden (Q), Christian Watson (Q) & Malik Heath
TE Colston Loveland
TE Tanner Hudson & WR Malik Washington
Key Defensive Players + Offensive Linemen
CB Sauce Gardner (concussion)
CB Trevon Diggs (concussion) + S Donovan Wilson (arm)
CB Paulson Adebo (knee) + S Jevon Holland (D - knee)
LB Divine Deablo (arm) + DB Billy Bowman (hamstring) + OLB Jalon Walker (groin)
DT Jeffery Simmons (hamstring)
OLB Haason Reddick (knee) + RG Luke Haggard (shoulder)
C Jake Brendel (hamstring) + DE Bryce Huff (hamstring)
CB Kyler Gordon (groin) + CB Tyrique Stevenson (shoulder) + LT Braxton Jones (knee)
CB Adoree' Jackson (concussion) + C Cam Jurgens (knee)
Listed as Questionable - Should Play 👍
QB Tyrod Taylor(knee)
RB D'Andre Swift (groin)
K Cairo Santos (thigh)
K Graham Gano (groin)
Truly Questionable / Game-Time Decisions 🤔
Early Games
QB Michael Penix (knee)
QB Lamar Jackson(hamstring)
RB Breece Hall (knee)
RB Tyler Allgeier (hip)
WR Josh Reynolds(hip)
TE Dalton Kincaid (oblique)
TE David Njoku (knee)
TE Mason Taylor (quad)
ESPN Sources: Falcons QB Kirk Cousins is "highly likely" to start Sunday's game vs. the Dolphins as Michael Penix recovers from a bone bruise to his knee.
Penix was limited at practice all week and Cousins worked with the first-team offense, gearing up to start Sunday. pic.twitter.com/790BrBoTBe
— Adam Schefter (@AdamSchefter) October 25, 2025
Late-Afternoon Games
There aren't any fantasy-relevant players listed as questionable for the three late games this week.
Primetime Games
WRs Matthew Golden (hip) + WR Christian Watson (IR) + K Brandon McManus (quad)
RB Kareem Hunt (knee) - MNF
Golden was an end-of-week addition to the injury report, listed as questionable after a limited practice Friday. Watson, meanwhile, will need to be activated from IR on Saturday in order to play Sunday. He's listed as questionable, after remaining limited in practice all week (perhaps a hint that he's another week or two away still?).
Key Defensive Players + O-Linemen
DT Vita Vea (foot)
LBs Matt Milano (pec) + Terrel Bernard (ankle)
CB Deommodore Lenoir (quad)
DE Trey Hendrickson (hip)
S Xavier Woods (ankle) + OLB Arden Key (quad)
S Juanyeh Thomas (migraine) + LT Tyler Guyton (glute)
C Zach Frazier (calf)
LT Josh Simmons (personal) + RG Trey Smith (back)











