
Isaac Brown
Out
Injury Lower Leg
Est. Return 11/29/2025
2025 Rush/Rec Stats
ATT
91
YDS
782
TD
5
YDS
42
TD
0
2025 Rush/Rec Projections
2025 Fantasy Outlook
Brown's 2025 season commenced with him working in a backfield committee alongside Maurice Turner, Keyjuan Brown, Duke Watson and Donald Chaney. By Week 5, Brown started to emerge as the top option in the backfield, amassing 13 carries for 72 yards and four grabs for 23 yards and a score in the contest. He served in more of a workhorse role down the stretch, handling at least 50 percent of the rushing attempts in five of the last games and 43 percent against Miami. The only two games he didn't? A game against Stanford in which he missed most of the game due to injury, and the subsequent week against Pitt in a blowout win. Watson is definitely an intriguing option behind Brown, but all signs point to Brown claiming a clear lead role in an explosive Cardinals offense in 2025, which should result in an improvement on his 147 carries for 1,074 yards and 11 touchdowns and 30 grabs for 152 yards and a score over the 12 regular-season contests last season, making him a top-flight fantasy running back option. Read Past Outlooks
Out for Week 13
Brown (lower leg) is out for Saturday's game at SMU, Pete Nakos of On3 reports.
ANALYSIS
Brown will log his third consecutive DNP because of a leg injury that has kept him out since Week 11. He has one more regular-season opportunity, which will come in Week 14 with a Kentucky-Louisville game on Nov. 29. Brown will look to do something similar to what he did last year, when the annual Louisville-Kentucky game saw him log 26 rushing attempts for 178 yards and two touchdowns.
Brown will log his third consecutive DNP because of a leg injury that has kept him out since Week 11. He has one more regular-season opportunity, which will come in Week 14 with a Kentucky-Louisville game on Nov. 29. Brown will look to do something similar to what he did last year, when the annual Louisville-Kentucky game saw him log 26 rushing attempts for 178 yards and two touchdowns.
College Football Stats
Loading CFB Stats...
2025 CFB Game Log
2025
2024
2025 CFB Game Log
Loading Game Log...
Cardinals Depth Chart
Our full team depth charts are reserved for RotoWire subscribers.
Subscribe Now
More Fantasy News
Remains out Friday
Brown (lower leg) did not appear on the teams injury report but will still not play in Friday's game versus Clemson, Matt McGavic of SI.com reports.
ANALYSIS
Subscribe now to instantly reveal our take on this news.
Subscribe now to instantly reveal our take on this news.
Absent from injury report
Brown (lower leg) isn't listed on Louisville's injury report ahead of a Friday night showdown with Clemson.
ANALYSIS
Subscribe now to instantly reveal our take on this news.
Subscribe now to instantly reveal our take on this news.
Will be out a while
Brown (lower leg) will be out for a while, Matt McGavic of Sports Illustrated reports.
ANALYSIS
Subscribe now to instantly reveal our take on this news.
Subscribe now to instantly reveal our take on this news.
May be sidelined 'a little while'
Brown (undisclosed) may be sidelined for "a little while," per head coach Jeff Brohm, Matt McGavic of SI.com reports.
ANALYSIS
Subscribe now to instantly reveal our take on this news.
Subscribe now to instantly reveal our take on this news.
Leaves game vs. Hokies with injury
Brown (undisclosed) was knocked out of Louisville's game against Virginia Tech and didn't return, per Damien Sordelett of The Roanoke Times.
ANALYSIS
Subscribe now to instantly reveal our take on this news.
Subscribe now to instantly reveal our take on this news.








