Isaac Brown

Running BackRB
 Free Agent
Out
Injury Transfer Portal
Est. Return 3/1/2026
2025 Fantasy Outlook
Brown's 2025 season commenced with him working in a backfield committee alongside Maurice Turner, Keyjuan Brown, Duke Watson and Donald Chaney. By Week 5, Brown started to emerge as the top option in the backfield, amassing 13 carries for 72 yards and four grabs for 23 yards and a score in the contest. He served in more of a workhorse role down the stretch, handling at least 50 percent of the rushing attempts in five of the last games and 43 percent against Miami. The only two games he didn't? A game against Stanford in which he missed most of the game due to injury, and the subsequent week against Pitt in a blowout win. Watson is definitely an intriguing option behind Brown, but all signs point to Brown claiming a clear lead role in an explosive Cardinals offense in 2025, which should result in an improvement on his 147 carries for 1,074 yards and 11 touchdowns and 30 grabs for 152 yards and a score over the 12 regular-season contests last season, making him a top-flight fantasy running back option. Read Past Outlooks
Entering transfer portal
RBNo Current School
Transfer Portal
January 1, 2026
Brown will enter the NCAA transfer portal, per Hayes Fawcett of On3.com.
ANALYSIS
Brown will enter the portal following two seasons with Louisville. The 5-foot-9 running back appeared in nine games for the Cardinals this past season, running for 884 yards and seven touchdowns while adding 13 receptions for 48 yards through the air as well. He will retain two years of eligibility at his next destination.
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2025 CFB Game Log
2025
2024
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Recent RotoWire Articles Featuring Isaac Brown See More
Recent RotoWire Articles Featuring Isaac Brown See More
More Fantasy News
Two touchdowns during bowl game
December 24, 2025
Brown totaled 10 rushes for 102 yards and two touchdowns and hauled in all two targets for six yards during Tuesday's 27-22 victory versus Toledo.
ANALYSIS
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Will play bowl game
December 23, 2025
Brown (lower leg) will play in Tuesday's bowl game with Toledo, Mark Blankenbaker of ESPN Louisville reports.
ANALYSIS
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Out for Week 14
Lower Leg
November 29, 2025
Brown (lower leg) is out for Saturday's game against Kentucky, Pete Thamel of ESPN reports.
ANALYSIS
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Questionable for Week 14
Lower Leg
November 29, 2025
Brown (lower leg) is questionable for Saturday's game against Kentucky, Pete Nakos of On3.com reports.
ANALYSIS
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Out for Week 13
Lower Leg
November 20, 2025
Brown (lower leg) is out for Saturday's game at SMU, Pete Nakos of On3 reports.
ANALYSIS
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