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Seahawks vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
23.0 Pts
Seahawks
20.5 Pts
Sunday September 7, 2025 at 4:05 PM ET
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SF
49ers Injury Report
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SEA
Seahawks Injury Report
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SF
49ers Lineup
Inactives
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SEA
Seahawks Lineup
Inactives
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SF
49ers News
#3 WR
Marquez Valdes-Scantling: Signed to active roster
Sep 2nd
The 49ers signed Valdes-Scantling to the active roster from the practice squad Tuesday, Aaron Wilson of KPRC 2 Houston reports.
#1 WR
Jauan Jennings: Retakes practice field
Sep 1st
Jennings (calf) is participating in practice Monday, Nick Wagoner of ESPN.com reports.
#5 WR
Jordan Watkins: Not practicing
Aug 28th
Watkins (ankle) didn't practice Thursday, Matt Barrows of The Athletic reports.
#3 RCB
Jakob Robinson: Moves to IR
Aug 27th
Robinson (forearm) was placed on injured reserve Tuesday.
#5 QB
Tanner Mordecai: Clears waivers
Aug 27th
Modecai (undisclosed) cleared waivers and reverted to injured reserve Wednesday.
#4 QB
Carter Bradley: Reverts to IR
Aug 27th
Bradley (undisclosed) cleared waivers and reverted to injured reserve Wednesday.
#1 SCB
Upton Stout: Returns to practice
Aug 27th
Stout (calf) returned to practice Wednesday, Jennifer Lee Chan of NBC Sports Bay Area reports.
#8 WR
Jacob Cowing: Lands on injured reserve
Aug 27th
The 49ers placed Cowing (hamstring) on injured reserve Wednesday.
#4 RB
Jordan James: Back on practice field
Aug 27th
James (finger) returned to practice Wednesday, Nick Wagoner of ESPN.com reports.
#3 LDT
Kevin Givens: Heads to IR
Aug 26th
Givens (pectoral) was placed on injured reserve Tuesday.
#2 LDE
Yetur Gross-Matos: Activated from PUP list
Aug 26th
Gross-Matos (undisclosed) was activated from the active/PUP list Tuesday.
#3 FS
Malik Mustapha: Lands on PUP list
Aug 26th
Mustapha (knee) was placed on the reserve/PUP list Tuesday.
#3 QB
Kurtis Rourke: Shifts to NFI list
Aug 26th
Rourke (knee) was placed on the reserve/non-football injury list Tuesday.
#7 WR
Brandon Aiyuk: Shifts to reserve/PUP list
Aug 26th
The 49ers moved Aiyuk (knee) to the reserve/PUP list Tuesday.
#4 WR
Skyy Moore: Makes first grab with 49ers
Aug 23rd
Moore recorded three receptions on six targets for 19 yards in Saturday's 30-23 preseason win over the Chargers.
#6 WR
Demarcus Robinson: Closes preseason with score
Aug 23rd
Robinson (suspension) recorded two receptions on two targets for 30 yards and a touchdown in Saturday's 30-23 preseason win over the Chargers.
#3 RB
Isaac Guerendo: Playing through shoulder inury
Aug 23rd
Guerendo (shoulder) rushed the ball eight times for 13 yards in Saturday's 30-23 preseason win over the Chargers. He added one reception on one target for one yard.
#1 TE
George Kittle: Not slated to suit up Saturday
Aug 23rd
Kittle isn't involved in warmups ahead of Saturday's preseason game against the Chargers, Matt Barrows of The Athletic reports.
#1 RB
Christian McCaffrey: Not in uniform Saturday
Aug 23rd
McCaffrey isn't warming up ahead of Saturday's preseason contest versus the Chargers, Matt Barrows of The Athletic reports.
#2 RB
Brian Robinson: Traded to 49ers
Aug 22nd
The Commanders are trading Robinson to the 49ers, Tom Pelissero of NFL Network reports.
#3 RDE
Robert Beal: Back from groin injury
Aug 21st
Beal (groin) returned to practice Thursday, Nick Wagoner of ESPN.com reports.
SEA
Seahawks News
#2 RILB
Chazz Surratt: Joins Seahawks
Aug 28th
Surratt signed with the Seahawks on Thursday.
#4 RG
Christian Haynes: Placed on IR, designated to return
Aug 27th
Haynes (pectoral) was placed on injured reserve with a designation to return Tuesday, John Boyle of the Seahawks' official website reports.
#7 WR
John Rhys Plumlee: Reverts to IR
Aug 27th
Plumlee (undisclosed) reverted to the Seahawks' injured reserve list Wednesday, per the NFL's transaction log.
#2 RCB
Derion Kendrick: Headed to Seattle
Aug 27th
Kendrick was claimed off waivers by the Seahawks on Wednesday, John Boyle of the team's official website reports.
#3 RDE
Rylie Mills: Starting career on NFI list
Aug 27th
Mills (knee) was moved to the reserve/non-football injury list Tuesday, John Boyle of the Seahawks' official site reports.
#2 NT
Johnathan Hankins: Starting season on NFI list
Aug 27th
Hankins (back) was moved to the reserve/non-football injury list Tuesday, John Boyle of the Seahawks' official site reports.
#3 RB
George Holani: Secures No. 3 job
Aug 27th
Holani was named the No. 3 running back after the Seahawks waived Damien Martinez on Tuesday, Michael-Shawn Dugar of The Athletic reports.
#3 WR
Tory Horton: Wins No. 3 job
Aug 26th
Horton (ankle) has beaten out Marquez Valdes-Scantling for the No. 3 wide receiver role, Michael-Shawn Dugar of The Athletic reports.
#2 RDE
Mike Morris: Dealing with concussion
Aug 25th
Morris was placed in concussion protocol Monday, Michael-Shawn Dugar of The Athletic reports.
#3 QB
Jalen Milroe: Will get special package of plays
Aug 25th
Milroe will have a special set of plays installed in Seattle's offense for regular-season games, Bob Condotta of The Seattle Times reports.
#6 WR
Cody White: Scores in preseason finale
Aug 24th
White caught three of five targets for 69 yards and a touchdown in Saturday's 20-7 preseason loss to the Packers.
#4 WR
Jake Bobo: Suffers concussion
Aug 23rd
Bobo suffered a concussion in Saturday's preseason loss to the Packers, Brady Henderson of ESPN.com reports.
#1 QB
Sam Darnold: Not playing in preseason finale
Aug 23rd
Darnold and other key players will be held out of Saturday's preseason finale at Green Bay, Brady Henderson of ESPN.com reports.
#1 LT
Charles Cross: Ramping up participation
Aug 21st
Cross (finger) participated in 11-on-11 team drills at practice Thursday, John Boyle of the Seahawks' official website reports.
#2 SLB
Uchenna Nwosu: Participates in workout
Aug 21st
Nwosu went through a workout in full pads Thursday, John Boyle of the Seahawks' official website reports.
#1 LILB
Tyrice Knight: Should be ready for season opener
Aug 21st
Knight (knee) is expected to be ready by Week 1 against the 49ers, head coach Mike Macdonald said Thursday, Brady Henderson of ESPN.com reports.