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Seahawks vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
24.0 Pts
Seahawks
21.5 Pts
Sunday September 7, 2025 at 4:05 PM ET
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SF
49ers Injury Report
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SEA
Seahawks Injury Report
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SF
49ers Lineup
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SEA
Seahawks Lineup
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SF
49ers News
#6 WR
Jordan Watkins: Paces pass catchers in defeat
Aug 9th
Watkins brought in three of six targets for 56 yards in the 49ers' 30-9 preseason loss to the Broncos on Saturday night.
#4 RB
Patrick Taylor: Scores rushing touchdown Saturday
Aug 9th
Taylor rushed five times for seven yards and a touchdown and secured his only target for four yards in the 49ers' 30-9 preseason loss to the Broncos on Saturday night.
#4 WR
Demarcus Robinson: Two catches in team debut
Aug 9th
Robinson brought in both targets for 20 yards in the 49ers' 30-9 preseason loss to the Broncos on Saturday night.
#3 RDE
Robert Beal: Sustains groin injury
Aug 9th
San Francisco head coach Kyle Shanahan said Saturday that Beal (groin) suffered an injury late during the team's 30-9 preseason loss to Denver, David Lombardi of SFStandard.com reports.
#3 FS
Marques Sigle: Initially injury diagnosis hopeful
Aug 9th
San Francisco head coach Kyle Shanahan said Saturday that Sigle will still undergo testing but that initial indications are that he's avoided a serious knee injury, Nick Wagoner of ESPN.com reports.
#2 SS
Richie Grant: To miss roughly a week
Aug 9th
San Francisco head coach Kyle Shanahan said Saturday that Grant (knee) did not suit up for the team's 30-9 preseason loss to Denver due to an injury and is expected to miss roughly one week, Nick Wagoner of ESPN.com reports.
#1 SCB
Upton Stout: Dealing with calf tightness
Aug 9th
San Francisco head coach Kyle Shanahan said Stout (calf) did not suit up for Saturday's 30-9 preseason loss to the Broncos due to calf tightness, Rich Cimini of ESPN.com reports.
#5 RB
Ameer Abdullah: Doesn't return Saturday
Aug 9th
Abdullah was forced out of Saturday's 30-9 preseason loss to the Broncos due to a rib injury.
#1 TE
George Kittle: Not expected to play Saturday
Aug 9th
Kittle isn't warming up ahead of Saturday's preseason game against the Broncos and isn't slated to play, Nick Wagoner of ESPN.com reports.
#1 QB
Brock Purdy: Not slated to play Saturday
Aug 9th
Purdy didn't warm up and isn't likely to play in Saturday's preseason game against Denver, Nick Wagoner of ESPN.com reports.
#1 RB
Christian McCaffrey: Not on track to play Saturday
Aug 9th
McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report.
#6 RB
Ke'Shawn Vaughn: Back with Niners
Aug 9th
The 49ers signed Vaughn to a contract Saturday.
#5 QB
Tanner Mordecai: Back in Bay Area
Aug 8th
The 49ers signed Mordecai to a contract Friday, Cam Inman of The San Jose Mercury News reports.
#12 WR
Equanimeous St. Brown: Lands on IR with foot injury
Aug 8th
The 49ers placed St. Brown on injured reserve Friday due to a foot injury, Cam Inman of The San Jose Mercury News reports.
#1 LDE
Mykel Williams: Hurts knee Thursday
Aug 7th
Williams is unlikely to suit up for Saturday's preseason game against Denver after exiting Thursday's practice due to a knee injury, Matt Barrows of The Athletic reports.
#3 RB
Jordan James: Breaks finger, out a few weeks
Aug 7th
San Francisco head coach Kyle Shanahan said Thursday that James will miss a couple weeks due to a broken finger, Cam Inman of The San Jose Mercury News reports.
#1 WR
Brandon Aiyuk: Not expected for Week 1
Aug 7th
San Francisco GM John Lynch said Thursday he "doesn't think" Aiyuk (ACL), who remains on the active/PUP list, will be cleared to play Week 1, Cam Inman of The San Jose Mercury News reports.
#3 WR
Ricky Pearsall: Standing out at practice
Aug 6th
Pearsall has impressed in recent practices and was a clear standout on offense Tuesday, connecting with quarterback Brock Purdy on five targets, Nick Wagoner of ESPN reports.
#3 DT2
Evan Anderson: Dealing with bruised knee
Aug 4th
Anderson (knee) did not practice Monday, Nick Wagoner of ESPN.com reports.
#2 RDE
Sam Okuayinonu: Misses practice Monday
Aug 4th
Okuayinonu (groin) sat out of practice Monday, Eric Branch of The San Francisco Chronicle reports.
#1 SS
Ji'Ayir Brown: Sits out of practice Monday
Aug 4th
Brown (ankle) did not participate in practice Monday, Jennifer Lee Chan of NBC Sports Bay Area reports.
#1 FB
Kyle Juszczyk: Misses practice Monday
Aug 4th
Juszczyk (Achilles) did not participate in practice Monday, Jennifer Lee Chan of NBC Sports Bay Area reports.
#1 LDT
Kevin Givens: Out with pectoral injury
Aug 4th
Givens is expected to miss the start of the 2025 regular season due to a pectoral injury, David Lombardi of SFStandard.com reports.
#2 WR
Jauan Jennings: Sidelined by calf again
Aug 4th
Jennings (calf) isn't practicing Monday, Jennifer Lee Chan of NBC Sports Bay Area reports.
#2 RB
Isaac Guerendo: Out for a few weeks
Aug 4th
San Francisco coach Kyle Shanahan said Monday that Guerendo (shoulder) is expected to miss a couple weeks, Matt Maiocco of NBC Sports Bay Area reports.
#1 K
Jake Moody: Appears to win job
Aug 4th
Moody is the only kicker on San Francisco's roster after the team released Greg Joseph on Monday, Matt Maiocco of NBC Sports Bay Area reports.
#1 LG
Ben Bartch: In line to start at LG
Aug 4th
Offensive line coach Chris Foerster declared Sunday that the starting left guard spot is "Bartch's job to lose," Jennifer Lee Chan of NBC Sports Bay Area reports.
#11 WR
Robbie Chosen: Signs with San Francisco
Aug 3rd
Chosen and the 49ers agreed on a one-year contract Sunday.
#2 SLB
Curtis Robinson: Activated off PUP list
Aug 2nd
The 49ers activated Robinson (undisclosed) off the active/PUP list Saturday, Vic Tafur of The Athletic reports.
#1 RCB
Deommodore Lenoir: Missing time with hip injury
Jul 31st
Lenoir is expected to miss the next few practices with a hip injury, David Lombardi of SFStandard.com reports.
#4 QB
Carter Bradley: Joins San Francisco
Jul 31st
The 49ers signed Bradley to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports.
#1 RT
Colton McKivitz: Returns from injury
Jul 31st
McKivitz (undisclosed) is fully healthy and participated in training camp Wednesday, Mike Maynard reports.
#2 RCB
Darrell Luter: Participating in training camp
Jul 31st
Luter (pelvis) has been participating in training camp, Grant Cohn of Sports Illustrated reports.
#2 DT2
Alfred Collins: Back at training camp
Jul 30th
Collins (calf) has fully participated in practices during the 49ers' first week of training camp, Mike Maynard of The Sporting News reports.
#7 WR
Russell Gage: Healthy start to camp
Jul 29th
Gage made an athletic grab during Tuesday's padded practice session, Matt Barrows of The Athletic reports.
#5 RDE
Tarron Jackson: Placed on IR
Jul 29th
The 49ers placed Jackson (undisclosed) on injured reserve Tuesday.
#1 WLB
Dee Winters: Competing for starting role in camp
Jul 27th
Winters drew praise from a star teammate at the start of training camp as the linebacker prepares to compete for a starting role in 2025, Vic Tafur of The Athletic reports.
#5 WR
Jacob Cowing: Hopeful to return in 2-3 weeks
Jul 27th
San Francisco coach Kyle Shanahan said Sunday that he's hopeful Cowing (hamstring) will be back by the week of Aug. 11 for joint practices with the Raiders, David Lombardi of SFStandard.com reports.
#1 LCB
Renardo Green: Will be out several weeks
Jul 27th
Green (hamstring) is expected to be sidelined for the next several weeks, David Lombardi of SFStandard.com reports.
SEA
Seahawks News
#1 LILB
Tyrice Knight: To miss a few weeks
Aug 9th
Seahawks head coach Mike Macdonald said Saturday that Knight (knee) will miss a "couple weeks" and is dealing with a "medical issue" in addition to his knee injury, Brady Henderson of ESPN.com reports.
#2 RG
Christian Haynes: Over pectoral issue
Aug 8th
Haynes (pectoral) played in Thursday night's preseason opener against the Bengals.
#3 LCB
Nehemiah Pritchett: Registers INT in preseason
Aug 8th
Pritchett recorded four solo tackles and two pass breakups, including an interception, in Thursday's 23-23 preseason tie versus the Raiders.
#6 RB
Anthony Tyus: Generates 23 yards
Aug 8th
Tyus rushed six times for 23 yards in Thursday's 23-23 preseason tie versus the Raiders.
#3 FS
Jerrick Reed: Makes five stops in tie
Aug 8th
Reed (quadriceps) made five tackles (three solo) in Thursday's 23-23 tie versus the Raiders.
#1 P
Michael Dickson: Booming punts Thursday
Aug 8th
Dickson punted four times for 222 yards (55.5 average) in Thursday's 23-23 tie versus the Raiders.
#1 K
Jason Myers: Misses extra point Thursday
Aug 8th
Myers connected on a 48-yard field goal and made two of three extra-point tries in Thursday's 23-23 tie versus the Raiders.
#6 WR
Ricky White: Makes one catch Thursday
Aug 8th
White (undisclosed) caught his lone target for 14 yards in Thursday's 23-23 preseason tie versus the Raiders.
#7 WR
Cody White: No catches in preseason opener
Aug 8th
White didn't catch either of his two targets in Thursday's 23-23 tie against the Raiders.
#8 WR
Dareke Young: One long catch Thursday
Aug 8th
Young caught one of three targets for 31 yards in Thursday's 23-23 tie against the Raiders.
#5 RB
Jacardia Wright: Scores in preseason tie
Aug 8th
Wright rushed seven times for 34 yards and a touchdown in Thursday's 23-23 preseason tie versus the Raiders.
#4 RB
Damien Martinez: Outplayed by Holani
Aug 7th
Martinez rushed six times for 10 yards and caught both of his targets for 15 yards in Thursday's 23-23 preseason tie against the Raiders. He also totaled 25 yards on two kickoff returns.
#3 RB
George Holani: Strengthens case for roster spot
Aug 7th
Holani rushed seven times for 61 yards and a touchdown while catching his only target for 20 yards in Thursday's 23-23 preseason tie against the Raiders.
#3 WR
Tory Horton: Adds to camp hype with preseason TD
Aug 7th
Horton caught three of seven targets for 31 yards and a touchdown in Thursday's 23-23 preseason tie against the Raiders. He also had a five-yard punt return.
#3 QB
Jalen Milroe: Minimal passing production in debut
Aug 7th
Milroe completed six of 10 passes for 61 yards while rushing three times for 38 yards in Thursday's 23-23 preseason tie against the Raiders.
#2 QB
Drew Lock: One TD, one INT in preseason start
Aug 7th
Lock completed 12 of 22 passes for 147 yards, one touchdown and one interception in Thursday's 23-23 preseason tie against the Raiders. He added three rushing attempts for four yards.
#2 RDE
Mike Morris: Set for preseason action
Aug 7th
Morris (leg) started Seattle's preseason game against the Raiders on Thursday, Curtis Crabtree of Fox 13 Seattle reports.
#9 WR
Steven Sims: Tending to hamstring issue
Aug 5th
Coach Mike Macdonald said Tuesday that Sims has a hamstring injury, Curtis Crabtree of Fox 13 Seattle reports.
#3 LILB
Josh Ross: Undergoes hand surgery
Aug 5th
Ross underwent surgery on his injured hand Tuesday, Michael-Shawn Dugar of The Athletic reports.
#1 C
Olu Oluwatimi: Dealing with back tightness
Aug 5th
Oluwatimi (back) didn't participate in Seattle's practice Tuesday, Michael-Shawn Dugar of The Athletic reports.
#2 LCB
Shaquill Griffin: Back with team Tuesday
Aug 5th
Griffin (personal) was present during Tuesday's training camp practice, Gregg Bell of The Tacoma News Tribune reports.
#1 RB
Kenneth Walker: Back at practice Tuesday
Aug 5th
Walker (foot) returned to practice Tuesday, Gregg Bell of The Tacoma News Tribune reports.
#4 FS
AJ Finley: Placed on IR
Aug 4th
The Seahawks placed Finley (knee) on injured reserve Monday, Corbin K. Smith of SI.com reports.
#2 WR
Cooper Kupp: Set to sit preseason opener
Aug 3rd
Kupp and the rest of the Seahawks' starters won't play in Thursday's preseason opener against the Raiders, Brady Henderson of ESPN.com reports.
#1 WR
Jaxon Smith-Njigba: Sitting out preseason opener
Aug 3rd
Smith-Njigba and the rest of the Seahawks' starters won't play in Thursday's preseason game against the Raiders, Brady Henderson of ESPN.com reports.
#2 RB
Zach Charbonnet: May see more work in 2025
Aug 3rd
Charbonnet is pushing for a timeshare in the backfield with Kenneth Walker in 2025, Brady Henderson of ESPN.com reports.
#1 QB
Sam Darnold: Won't play in preseason opener
Aug 3rd
Darnold and the rest of the Seahawks' starters won't play in Thursday's preseason game versus the Raiders, Gregg Bell of The Tacoma News Tribune reports.
#2 FS
Nick Emmanwori: Lining up all over formation
Aug 2nd
Emmanwori is practicing at safety, nickel corner and outside linebacker, Gregg Bell of The Tacoma News Tribune reports.
#1 RILB
Ernest Jones: Back in action
Aug 1st
Jones (knee/personal) returned to practice Friday, Gregg Bell of The Tacoma News Tribune reports.
#1 LT
Charles Cross: Undergoes finger surgery
Jul 31st
Cross underwent surgery Thursday to repair a dislocated finger but is expected to be ready for the Seahawks' Week 1 season opener against the 49ers, Ian Rapoport of NFL Network reports.
#1 NT
Byron Murphy: Aiming for more pass-rushing work
Jul 29th
Murphy (back) is expected to be a bigger factor as a pass rusher in 2025, John Boyle of the Seahawks' official site reports.
#7 RB
Kenny McIntosh: Placed on IR
Jul 28th
The Seahawks placed McIntosh (knee) on injured reserve Monday, Curtis Crabtree of Fox 13 Seattle reports.
#2 TE
Elijah Arroyo: Competing with AJ Barner
Jul 28th
Arroyo is thriving as a pass catcher early in training camp, but AJ Barner's blocking makes him the favorite to replace Noah Fant as Seattle's starting tight end, according to Gregg Bell of The Tacoma News Tribune.