Menu
Fantasy Home
NFL Betting

Seahawks vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
23.0 Pts
Seahawks
20.5 Pts
Sunday September 7, 2025 at 4:05 PM ET
Loading Possible Bets...
Player Props
Loading Advanced NFL Stats...
SF
49ers Injury Report
Loading 49ers Injuries...
SEA
Seahawks Injury Report
Loading Seahawks Injuries
SF
49ers Lineup
Inactives
    None reported yet.
SEA
Seahawks Lineup
Inactives
    None reported yet.
SF
49ers News
#1 RG
Dominick Puni: Limited practice Wednesday
Sep 3rd
Puni (knee) was a limited participant at the 49ers' practice Wednesday, Cam Inman of The San Jose Mercury News reports.
#1 LG
Ben Bartch: Full practice Wednesday
Sep 3rd
Bartch (elbow) was a full participant at the 49ers' practice Wednesday, Cam Inman of The San Jose Mercury News reports.
#1 WR
Jauan Jennings: Inks incentive-based contract
Sep 3rd
The 49ers and Jennings (calf) agreed Wednesday to add $3 million in play-time incentives to his contract for the 2025 season, Adam Schefter of ESPN reports.
#2 RDE
Sam Okuayinonu: Logs full practice Wednesday
Sep 3rd
Okuayinonu (shoulder) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#2 LDE
Yetur Gross-Matos: Working through knee issue
Sep 3rd
Gross-Matos (knee) did not participate in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#2 DT2
CJ West: Logs full practice Wednesday
Sep 3rd
West (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 SCB
Upton Stout: Recovered from calf injury
Sep 3rd
Stout (calf) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 LDE
Mykel Williams: Full participant in practice
Sep 3rd
Williams (knee) practiced in full Wednesday, Cam Inman of The San Jose Mercury News reports.
#1 FS
Jason Pinnock: Logs full practice
Sep 3rd
Pinnock (heel) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 RCB
Deommodore Lenoir: Recovered from hip injury
Sep 3rd
Lenoir (hip) was not listed on the 49er's injury report Wednesday, Cam Inman of The San Jose Mercury News reports.
#1 RDE
Nick Bosa: Fades injury report
Sep 3rd
Bosa (neck) was not listed on Wednesday's injury report, Cam Inman of The San Jose Mercury News reports.
#2 QB
Mac Jones: Past knee injury
Sep 3rd
Jones (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#5 WR
Jordan Watkins: Doesn't practice Wednesday
Sep 3rd
Watkins (ankle) was a non-participant at Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#4 RB
Jordan James: Gets in limited practice
Sep 3rd
James (finger) was limited at Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#3 RB
Isaac Guerendo: Full practice Wednesday
Sep 3rd
Guerendo (shoulder) practiced fully Wednesday, Cam Inman of The San Jose Mercury News reports.
#3 WR
Marquez Valdes-Scantling: Signed to active roster
Sep 2nd
The 49ers signed Valdes-Scantling to the active roster from the practice squad Tuesday, Aaron Wilson of KPRC 2 Houston reports.
#3 RCB
Jakob Robinson: Moves to IR
Aug 27th
Robinson (forearm) was placed on injured reserve Tuesday.
#4 QB
Carter Bradley: Reverts to IR
Aug 27th
Bradley (undisclosed) cleared waivers and reverted to injured reserve Wednesday.
#8 WR
Jacob Cowing: Lands on injured reserve
Aug 27th
The 49ers placed Cowing (hamstring) on injured reserve Wednesday.
#3 LDT
Kevin Givens: Heads to IR
Aug 26th
Givens (pectoral) was placed on injured reserve Tuesday.
#3 FS
Malik Mustapha: Lands on PUP list
Aug 26th
Mustapha (knee) was placed on the reserve/PUP list Tuesday.
#3 QB
Kurtis Rourke: Shifts to NFI list
Aug 26th
Rourke (knee) was placed on the reserve/non-football injury list Tuesday.
#7 WR
Brandon Aiyuk: Shifts to reserve/PUP list
Aug 26th
The 49ers moved Aiyuk (knee) to the reserve/PUP list Tuesday.
#4 WR
Skyy Moore: Makes first grab with 49ers
Aug 23rd
Moore recorded three receptions on six targets for 19 yards in Saturday's 30-23 preseason win over the Chargers.
#6 WR
Demarcus Robinson: Closes preseason with score
Aug 23rd
Robinson (suspension) recorded two receptions on two targets for 30 yards and a touchdown in Saturday's 30-23 preseason win over the Chargers.
#1 TE
George Kittle: Not slated to suit up Saturday
Aug 23rd
Kittle isn't involved in warmups ahead of Saturday's preseason game against the Chargers, Matt Barrows of The Athletic reports.
#1 RB
Christian McCaffrey: Not in uniform Saturday
Aug 23rd
McCaffrey isn't warming up ahead of Saturday's preseason contest versus the Chargers, Matt Barrows of The Athletic reports.
#2 RB
Brian Robinson: Traded to 49ers
Aug 22nd
The Commanders are trading Robinson to the 49ers, Tom Pelissero of NFL Network reports.
#3 RDE
Robert Beal: Back from groin injury
Aug 21st
Beal (groin) returned to practice Thursday, Nick Wagoner of ESPN.com reports.
SEA
Seahawks News
#2 RDE
Mike Morris: Not listed on injury report
Sep 3rd
Morris (concussion) wasn't listed on Seattle's injury report Wednesday, John Boyle of the team's official site reports.
#1 LT
Charles Cross: Taken off injury report
Sep 3rd
Cross (finger) wasn't listed on Seattle's injury report Wednesday, John Boyle of the team's official site reports.
#1 LILB
Tyrice Knight: Not listed on injury report
Sep 3rd
Knight (knee) wasn't listed on Seattle's injury report Wednesday, John Boyle of the team's official site reports.
#2 SLB
Uchenna Nwosu: Limited in practice Wednesday
Sep 3rd
Nwosu (knee) was a limited participant in Seattle's practice Wednesday, John Boyle of the team's official site reports.
#6 WR
Cody White: Dealing with shoulder injury
Sep 3rd
White (shoulder) was a limited participant in Seattle's practice Wednesday, John Boyle of the team's official site reports.
#5 WR
Dareke Young: Limited participant in practice
Sep 3rd
Young (hamstring) was a limited participant in Seattle's practice Wednesday, John Boyle of the team's official site reports.
#4 WR
Jake Bobo: Remains limited by concussion
Sep 3rd
Bobo (concussion) practiced in a limited capacity Wednesday, John Boyle of the Seahawks' official site reports.
#3 WR
Tory Horton: Logs full practice Wednesday
Sep 3rd
Horton (ankle) was a full practice participant Wednesday, John Boyle of the Seahawks' official site reports.
#2 RILB
Chazz Surratt: Joins Seahawks
Aug 28th
Surratt signed with the Seahawks on Thursday.
#4 RG
Christian Haynes: Placed on IR, designated to return
Aug 27th
Haynes (pectoral) was placed on injured reserve with a designation to return Tuesday, John Boyle of the Seahawks' official website reports.
#2 RCB
Derion Kendrick: Headed to Seattle
Aug 27th
Kendrick was claimed off waivers by the Seahawks on Wednesday, John Boyle of the team's official website reports.
#3 RDE
Rylie Mills: Starting career on NFI list
Aug 27th
Mills (knee) was moved to the reserve/non-football injury list Tuesday, John Boyle of the Seahawks' official site reports.
#2 NT
Johnathan Hankins: Starting season on NFI list
Aug 27th
Hankins (back) was moved to the reserve/non-football injury list Tuesday, John Boyle of the Seahawks' official site reports.
#3 RB
George Holani: Secures No. 3 job
Aug 27th
Holani was named the No. 3 running back after the Seahawks waived Damien Martinez on Tuesday, Michael-Shawn Dugar of The Athletic reports.
#3 QB
Jalen Milroe: Will get special package of plays
Aug 25th
Milroe will have a special set of plays installed in Seattle's offense for regular-season games, Bob Condotta of The Seattle Times reports.
#1 QB
Sam Darnold: Not playing in preseason finale
Aug 23rd
Darnold and other key players will be held out of Saturday's preseason finale at Green Bay, Brady Henderson of ESPN.com reports.