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Seahawks vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
22.5 Pts
Seahawks
21.0 Pts
Sunday September 7, 2025 at 4:05 PM ET
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SF
49ers Injury Report
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SEA
Seahawks Injury Report
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SF
49ers Lineup
Inactives
    None reported yet.
SEA
Seahawks Lineup
Inactives
    None reported yet.
SF
49ers News
#1 RG
Dominick Puni: Ready to face Seahawks
Sep 5th
Puni (knee) does not have an injury designation ahead of Sunday's game against the Seahawks, Michael-Shawn Dugar of The Athletic reports.
#2 LDE
Yetur Gross-Matos: Cleared for Week 1
Sep 5th
Gross-Matos (knee) does not have an injury designation ahead of Sunday's game against the Seahawks, Michael-Shawn Dugar of The Athletic reports.
#5 WR
Jordan Watkins: Doubtful for Sunday
Sep 5th
Watkins (ankle) is listed as doubtful for Sunday's game at Seattle, Matt Maiocco of NBC Sports Bay Area reports.
#1 RB
Christian McCaffrey: Plans to play Sunday
Sep 5th
McCaffrey (calf), who is listed as questionable for Sunday's game at Seattle, said Friday that he "feels great" and is preparing to suit up Week 1, David Lombardi of SFStandard.com reports.
#4 RB
Jordan James: Doubtful for Week 1
Sep 5th
James (finger) is listed as doubtful for Sunday's contest in Seattle, Matt Maiocco of NBC Sports Bay Area reports.
#1 WR
Jauan Jennings: Week 1 appearance on tap
Sep 5th
Coach Kyle Shanahan said Friday that Jennings (calf) is "good to go" for Sunday's contest at Seattle, Cam Inman of The San Jose Mercury News reports. "He's had a real good week," Shanahan added. "[He's] gotten better and better throughout the week, and I'm excited to see him out there Sunday."
#1 LG
Ben Bartch: Full practice Wednesday
Sep 3rd
Bartch (elbow) was a full participant at the 49ers' practice Wednesday, Cam Inman of The San Jose Mercury News reports.
#2 RDE
Sam Okuayinonu: Logs full practice Wednesday
Sep 3rd
Okuayinonu (shoulder) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#2 DT2
CJ West: Logs full practice Wednesday
Sep 3rd
West (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 SCB
Upton Stout: Recovered from calf injury
Sep 3rd
Stout (calf) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 LDE
Mykel Williams: Full participant in practice
Sep 3rd
Williams (knee) practiced in full Wednesday, Cam Inman of The San Jose Mercury News reports.
#1 FS
Jason Pinnock: Logs full practice
Sep 3rd
Pinnock (heel) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 RCB
Deommodore Lenoir: Recovered from hip injury
Sep 3rd
Lenoir (hip) was not listed on the 49er's injury report Wednesday, Cam Inman of The San Jose Mercury News reports.
#1 RDE
Nick Bosa: Fades injury report
Sep 3rd
Bosa (neck) was not listed on Wednesday's injury report, Cam Inman of The San Jose Mercury News reports.
#2 QB
Mac Jones: Past knee injury
Sep 3rd
Jones (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#3 RB
Isaac Guerendo: Full practice Wednesday
Sep 3rd
Guerendo (shoulder) practiced fully Wednesday, Cam Inman of The San Jose Mercury News reports.
#3 WR
Marquez Valdes-Scantling: Signed to active roster
Sep 2nd
The 49ers signed Valdes-Scantling to the active roster from the practice squad Tuesday, Aaron Wilson of KPRC 2 Houston reports.
#3 RCB
Jakob Robinson: Moves to IR
Aug 27th
Robinson (forearm) was placed on injured reserve Tuesday.
#8 WR
Jacob Cowing: Lands on injured reserve
Aug 27th
The 49ers placed Cowing (hamstring) on injured reserve Wednesday.
#3 LDT
Kevin Givens: Heads to IR
Aug 26th
Givens (pectoral) was placed on injured reserve Tuesday.
#3 FS
Malik Mustapha: Lands on PUP list
Aug 26th
Mustapha (knee) was placed on the reserve/PUP list Tuesday.
#3 QB
Kurtis Rourke: Shifts to NFI list
Aug 26th
Rourke (knee) was placed on the reserve/non-football injury list Tuesday.
#7 WR
Brandon Aiyuk: Shifts to reserve/PUP list
Aug 26th
The 49ers moved Aiyuk (knee) to the reserve/PUP list Tuesday.
#4 WR
Skyy Moore: Makes first grab with 49ers
Aug 23rd
Moore recorded three receptions on six targets for 19 yards in Saturday's 30-23 preseason win over the Chargers.
#6 WR
Demarcus Robinson: Closes preseason with score
Aug 23rd
Robinson (suspension) recorded two receptions on two targets for 30 yards and a touchdown in Saturday's 30-23 preseason win over the Chargers.
#1 TE
George Kittle: Not slated to suit up Saturday
Aug 23rd
Kittle isn't involved in warmups ahead of Saturday's preseason game against the Chargers, Matt Barrows of The Athletic reports.
SEA
Seahawks News
#5 WR
Dareke Young: Out for Sunday
Sep 5th
Young (hamstring) won't play in Sunday's matchup against the 49ers, Brady Henderson of ESPN.com reports.
#2 SLB
Uchenna Nwosu: Missing Week 1
Sep 5th
Nwosu (knee) has been ruled out ahead of Sunday's contest against the 49ers, Brady Henderson of ESPN.com reports.
#6 WR
Cody White: Ready for Sunday
Sep 5th
White (shoulder) has no injury designation ahead of Sunday's matchup against the 49ers, Brady Henderson of ESPN.com reports.
#1 LCB
Riq Woolen: Past illness
Sep 5th
Woolen (illness) carries no injury designation into Sunday's game against the 49ers, Brady Henderson of ESPN.com reports.
#4 WR
Jake Bobo: Doesn't clear protocol for Week 1
Sep 5th
Bobo (concussion) has been ruled out for Sunday's game against the 49ers, John Boyle of the Seahawks' official site reports.
#1 RG
Anthony Bradford: Ready to rock
Sep 5th
Bradford (back) has no injury designation ahead of Sunday's matchup against the 49ers, Brady Henderson of ESPN.com reports.
#1 RT
Abraham Lucas: Nabs extension from Seattle
Sep 4th
Lucas and the Seahawks agreed Thursday on a three-year, $46 million contract extension, Mike Garafolo of NFL Network reports.
#2 RDE
Mike Morris: Not listed on injury report
Sep 3rd
Morris (concussion) wasn't listed on Seattle's injury report Wednesday, John Boyle of the team's official site reports.
#1 LT
Charles Cross: Taken off injury report
Sep 3rd
Cross (finger) wasn't listed on Seattle's injury report Wednesday, John Boyle of the team's official site reports.
#1 LILB
Tyrice Knight: Not listed on injury report
Sep 3rd
Knight (knee) wasn't listed on Seattle's injury report Wednesday, John Boyle of the team's official site reports.
#3 WR
Tory Horton: Logs full practice Wednesday
Sep 3rd
Horton (ankle) was a full practice participant Wednesday, John Boyle of the Seahawks' official site reports.
#2 RILB
Chazz Surratt: Joins Seahawks
Aug 28th
Surratt signed with the Seahawks on Thursday.
#2 RG
Christian Haynes: Placed on IR, designated to return
Aug 27th
Haynes (pectoral) was placed on injured reserve with a designation to return Tuesday, John Boyle of the Seahawks' official website reports.
#2 RCB
Derion Kendrick: Headed to Seattle
Aug 27th
Kendrick was claimed off waivers by the Seahawks on Wednesday, John Boyle of the team's official website reports.
#3 RDE
Rylie Mills: Starting career on NFI list
Aug 27th
Mills (knee) was moved to the reserve/non-football injury list Tuesday, John Boyle of the Seahawks' official site reports.
#2 NT
Johnathan Hankins: Starting season on NFI list
Aug 27th
Hankins (back) was moved to the reserve/non-football injury list Tuesday, John Boyle of the Seahawks' official site reports.
#3 RB
George Holani: Secures No. 3 job
Aug 27th
Holani was named the No. 3 running back after the Seahawks waived Damien Martinez on Tuesday, Michael-Shawn Dugar of The Athletic reports.
#3 QB
Jalen Milroe: Will get special package of plays
Aug 25th
Milroe will have a special set of plays installed in Seattle's offense for regular-season games, Bob Condotta of The Seattle Times reports.
#1 QB
Sam Darnold: Not playing in preseason finale
Aug 23rd
Darnold and other key players will be held out of Saturday's preseason finale at Green Bay, Brady Henderson of ESPN.com reports.