Manchester United need a point against CSKA Moscow to lock up the top spot in their group, and Marcus Rashford could have an important role on set pieces.
Napoli need a win and help elsewhere to qualify for the knockout rounds of the Champions League, and they'll look for Lorenzo Insigne to make a big impact.
Roma are the biggest favorites with the highest implied goal odds among Tuesday's eight Champions League matches, and they'll rely on Edin Dzeko to lead them to the round of 16.
Paulo Dybala has yet to find the scoresheet during Champions League play, but Schuyler Redpath is expecting a breakout performance Tuesday at Olympiacos.
Andrew Laird and Jordan Cooper review their DraftKings cash lineups from this past Saturday's Premier League slate before jumping in to preview Tuesday's eight Champions League matches.
Roma will book their place in the knockout rounds with a win against Qarabag on Tuesday, and they'll rely on Edin Dzeko to put them ahead.
Sunday's three-game interleague slate doesn't have any dominant favorites, so fantasy players could look to rack up peripheral stats with players like Jordan Amavi.
With Manchester City one of four teams on Sunday's two-game slate, fantasy managers will have a tough time fitting in as many Citizens as possible.
Mohamed Salah has been on a tear of late, and with Liverpool facing Brighton on Saturday, he's likely to be a very popular fantasy option.
Harry Kane is likely to draw plenty of attention as Spurs look to bounce back at Watford on Saturday, but a few of his teammates may be better fantasy options.
Playing at home against Swansea City is always a place to look for fantasy value, and Eric Maxim Choupo-Moting sticks out among the Stoke City attackers.
Andrew Laird and Mike Gottlieb preview the upcoming weekend of Premier League matches, including how fantasy managers can adjust to the squad rotation that many teams are expected to use.
Chelsea's home match against Newcastle on Saturday could have plenty of fantasy owners giving the captain's armband to Alvaro Morata.
With Tottenham possibly rotating their fullbacks after Serge Aurier and Danny Rose started during the midweek, Kieran Trippier could regain his spot in the starting XI at Watford.
Andrew Laird and Jordan Cooper preview Saturday's seven-game daily fantasy Premier League slate, including whether we can finally trust Gylfi Sigurdsson again and if paying up for the Liverpool forwards is worth it.
Two teams have better win odds than Tottenham on Saturday's seven-game slate, but no one has better anytime goal scoring odds than Harry Kane.
Mohamed Salah just can't stop scoring, but only one of our FPL experts has him as the top fantasy midfielder in Gameweek 15.
Liverpool could rotate a bit after last weekend's match against Chelsea, but if James Milner keeps his spot in the starting XI, he could make a solid play on The Six.