Real Madrid have a commanding 3-0 aggregate lead over Juventus, but that isn't likely to slow down Cristiano Ronaldo, who has been unstoppable in Champions League play this season.
Manchester City have a big mountain to climb as they look to make up a three-goal deficit to Liverpool, and they'll look for Sergio Aguero to help them get there.
Chelsea and Arsenal are strong favorites on Sunday's two-game slate, which means fantasy owners will surely have to consider Eden Hazard.
The Atlanta United-Los Angeles FC match is expected to have plenty of fireworks, which means Josef Martinez could be a popular fantasy option on Saturday's five-game slate.
With Mohamed Salah not expected to feature Saturday against Everton, RotoWire's Schuyler Redpath has a few LFC value plays that could pay off big.
Fantasy players are likely to be all over Tottenham on Saturday, but Leicester City's Riyad Mahrez offers an alternative with plenty of upside.
Fantasy players will want Spurs exposure Saturday at Stoke, and while some may be thinking about how to choose between Harry Kane and Christian Eriksen, there's a solid path to rostering both.
With Tottenham traveling to face Stoke City on Saturday, RotoWire's Schuyler Redpath sees a clear path to a full-blown Spurs stack.
Tijuana and the New England Revolution are the two bigger favorites on Friday's three-game late interleague slate, but all three matches figure to be fairly close.
Paris Saint-Germain are heavy favorites away to St. Etienne on Friday, and with Neymar still sidelined due to injury, Edinson Cavani will continue to shoulder a bigger scoring load.
Despite Manchester City and Manchester United being on Saturday's seven-game slate, fading Tottenham's Harry Kane could be very detrimental, according to Evan Morter.
Andrew Laird and Jordan Cooper briefly discuss this week's Champions League matches before diving into Saturday's seven-game daily fantasy Premier League slate, with Harry Kane the big topic regarding his potential ownership percentage in DraftKings' King
Andrew Laird and Mike Gottlieb preview Gameweek 33 of the Premier League, a huge weekend that will include both the Merseyside and Manchester derbies.
A home match against West Ham will have plenty of fantasy managers looking to Chelsea for their fantasy captain, and RotoWire's Adam Zdroik thinks Willian leads the way.
Andrew Laird, JD Bazzo and Schuyler Redpath preview Week 6 of the fantasy MLS season, including how many players we can roster from the Atlanta-LA FC match and what the short-term realistic expectations are for Zlatan Ibrahimovic.
Harry Kane surprisingly returned from injury last weekend, and he has a prime matchup Saturday against Stoke City if he can get back in the starting XI.
Arsenal will be without Pierre-Emerick Aubameyang on Thursday against CSKA Moscow, which will leave Alexandre Lacazette to spearhead the attack.
Saturday's Atlanta-LA FC match figures to get a ton of attention from fantasy players, which means Josef Martinez could be a popular captain option.