The Chiefs might assign star corner Trent McDuffie to A.J. Brown, but if so they risk setting loose DeVonta Smith against Kansas City's more modest corners.
Amon-Ra St. Brown against Noah Igbinoghene could prove to be a problem for Washington's defense.
The Texans insist on playing safeties in the slot, which might be a way of asking for trouble from Ladd McConkey.
Justin Jefferson looks truly unstoppable in a game where the Vikings need points and the Lions probably can't cover.
Michael Pittman could be a challenging cover for the Giants' shorter and light cornerbacks.
Michael Penix is unproven, but the quarterback change gives new hope to Falcons pass catchers like Drake London.
Ever since Marshon Lattimore switched teams, Washington's Week 15 matchup with New Orleans became a good matchup for Terry McLaurin.
Now that he's off the injury report, Mike Evans should be set up for a strong game against Las Vegas.
Terry McLaurin should stay hot against a Titans defense starting its third- and fourth-string corners on the boundary.
There's a chance DJ Moore maintains his momentum against a Detroit secondary without Carlton Davis on Thursday.
The Buccaneers need to get the ball to Mike Evans, and it's not obvious what the Giants defense can do to stop it.
The Ravens might want to shadow George Pickens with Marlon Humphrey, because the other Ravens corners can't cover Pickens.
Deebo Samuel could go nuts as the desperate 49ers take aim at a weak Tampa Bay corner rotation.
Justin Jefferson will almost certainly have a big game Sunday, and the Colts pass defense is weak enough for Jordan Addison to get rolling in the same game.
With Tua Tagovailoa back in the lineup Jaylen Waddle should get rolling against Arizona, and the same is true of Tyreek Hill if he plays through his foot injury.
Drake London's breakout should continue against a Seattle secondary that might be without its two starting boundary corners.
The showdown between Detroit and Dallas could set up a punch-for-punch heavyweight contest where CeeDee Lamb and Amon-Ra St. Brown both go off.
Michael Pittman got back on track in Week 4 and should keep it rolling in Week 5, as neither the Jags nor Colts have viable coverage personnel.
George Pickens should get going against an Indianapolis defense with questionable boundary personnel
If Patrick Surtain shadows Mike Evans on the boundary then it could create a target funnel to Chris Godwin in the slot.
Amon-Ra St. Brown will likely torch a thin Buccaneers secondary playing without its star enforcer in Antoine Winfield.
Mike Evans has to slow down eventually, but probably not against Washington's undersized boundary corners.
Facing a tough defense with the bull's eye on him, Sunday's showdown with Buffalo will help clarify just how good Rashee Rice can be.
The Steelers might assign Joey Porter to Stefon Diggs, but if so the decision might backfire against Pittsburgh.
Nico Collins could see an enormous target share with the Texans managing multiple wideout injuries.
CeeDee Lamb could have one of his biggest games playing against a Lions defense that's tougher against the run than the pass.
DK Metcalf could pose a major big-play threat to Tennessee's injury-challenged corner rotation.
If New England prioritizes defending Travis Kelce then the Pats might not have leftover personnel to cover Rashee Rice.
Ja'Marr Chase should keep rolling against a Colts secondary with poor boundary corner personnel.
The Saints are tougher on the boundary than in the slot, which should provoke a big game from Amon-Ra St. Brown.