Justin Jefferson will almost certainly have a big game Sunday, and the Colts pass defense is weak enough for Jordan Addison to get rolling in the same game.
With Tua Tagovailoa back in the lineup Jaylen Waddle should get rolling against Arizona, and the same is true of Tyreek Hill if he plays through his foot injury.
Drake London's breakout should continue against a Seattle secondary that might be without its two starting boundary corners.
The showdown between Detroit and Dallas could set up a punch-for-punch heavyweight contest where CeeDee Lamb and Amon-Ra St. Brown both go off.
Michael Pittman got back on track in Week 4 and should keep it rolling in Week 5, as neither the Jags nor Colts have viable coverage personnel.
George Pickens should get going against an Indianapolis defense with questionable boundary personnel
If Patrick Surtain shadows Mike Evans on the boundary then it could create a target funnel to Chris Godwin in the slot.
Amon-Ra St. Brown will likely torch a thin Buccaneers secondary playing without its star enforcer in Antoine Winfield.
Mike Evans has to slow down eventually, but probably not against Washington's undersized boundary corners.
Facing a tough defense with the bull's eye on him, Sunday's showdown with Buffalo will help clarify just how good Rashee Rice can be.
The Steelers might assign Joey Porter to Stefon Diggs, but if so the decision might backfire against Pittsburgh.
Nico Collins could see an enormous target share with the Texans managing multiple wideout injuries.
CeeDee Lamb could have one of his biggest games playing against a Lions defense that's tougher against the run than the pass.
DK Metcalf could pose a major big-play threat to Tennessee's injury-challenged corner rotation.
If New England prioritizes defending Travis Kelce then the Pats might not have leftover personnel to cover Rashee Rice.
Ja'Marr Chase should keep rolling against a Colts secondary with poor boundary corner personnel.
The Saints are tougher on the boundary than in the slot, which should provoke a big game from Amon-Ra St. Brown.
The Indianapolis secondary is weakest on the boundary and downfield, where Mike Evans is at his best.
CeeDee Lamb has been a menace from the slot, where Washington lacks the coverage personnel to defend itself.
Playing at home and against the Bears, the Week 11 setup couldn't be much easier for Amon-Ra St. Brown.
DeAndre Hopkins should be able to get rolling against a struggling and injured Tampa Bay corner rotation.
The Jets aren't an easy matchup for Keenan Allen, but the Chargers passing game has no other viable route for production in Week 9.
Nico Collins and Tank Dell should come roaring out of the bye week against a battered and weak Carolina secondary.
A.J. Brown and DeVonta Smith are glaring mismatches against the Dolphins corners, setting the stage for a runaway shootout.
The Vikings face a simple reality Sunday: either Jordan Addison has a strong game, or the Minnesota passing game falls apart.
It might be now or never for DeAndre Hopkins, who catches the Colts battered and weak at cornerback.
The Dolphins are looking to bring a shootout to the Bills, but Stefon Diggs is prepared to shoot back against Miami's questionable pass defense.
Christian Kirk should maintain momentum against a Houston defense without two of its top three corners, including their slot defender.
Drake London is due for a bounce-back after no catches in Week 1, but Jaire Alexander could deny it anyway.
The Colts' cornerback personnel is weak but their run defense is strong, setting up a feast for Calvin Ridley and the Jags passing game.