Groups C and D finish up Tuesday, with Germany and Spain well positioned to take the top spots, but some potential squad rotation could open up fantasy rosters.
Group B finishes up Monday, with three teams in reach of finishing on top of the table before heading to the knockout rounds.
The final matches of Group A will be played at the same time Sunday, with France needing only a draw to finish first.
Copa America and Euros may still be going on, but Major League Soccer is back in action with a heavy Saturday slate.
The United States already clinched their spot in the semifinal, while six teams will compete for the last three spots over the next two days.
When Portugal are on the slate, the simple question is: do we fade Cristiano Ronaldo?
Zlatan Ibrahimovic is back in action Friday, but is he worth taking against the very strong Italy defense?
Copa America heads to the quarterfinal round, with DraftKings breaking out an always difficult two-game, two-day slate.
Two huge grudge matches highlight Thursday's three-game slate, though the other game of the day could produce the most fantasy points.
The host nation returns to action for Wednesday's three-game slate, with many fantasy owners likely flocking toward France's Dimitri Payet after his stunning opening game.
Cristiano Ronaldo highlights Tuesday's Euro action, but fantasy owners will need to find some other pieces to fit together with the Portuguese superstar.
The group stage matches finish up Tuesday, but there is still plenty to be decided in Groups C and D, which should produce plenty of fantasy points.
There aren't many elite goal-scorers on Monday's slate, despite high profile teams like Belgium and Italy, so it will be vital to find players who can contribute with other stats.
Groups B and C will be decided Sunday and Monday, respectively, with plenty of fantasy points expected as teams go all-out to grab the final three points.
Sunday's three-game slate has a number of high-profile players, including Bayern Munich teammates Robert Lewandowski and Thomas Muller.
With Argentina, Chile and Colombia, not to mention the United States, in action over the next two days, daily fantasy soccer players will have plenty of upper-tier options to choose from.
The Wednesday-Thursday slate is highlighted by Brazil, Uruguay and Mexico, with plenty of fantasy points to be had. JD Bazzo breaks down the top plays.
The 2016 European Championship kicks off this weekend, and Chris Henne returns with his top picks for DFS contests.