Sunday's action is highlighted by the Hudson River Derby, which ended in a 7-0 Red Bulls win at Yankee Stadium earlier this season.
Saturday's three-game MLS slate includes plenty of fireworks, with Toronto FC's Sebastian Giovinco leading the charge.
Iceland's surprising run to the quarterfinal has them matched up with the home nation on Sunday, but Saturday features a heavyweight battle between Italy and Germany.
The MLS schedule will be a bit staggered for the July 4 weekend, with only two games kicking off the Friday DFS slate.
Cristiano Ronaldo highlights the players available for the two opening quarterfinal matches, but there are a few other stars who could outproduce him.
The Round of 16 concludes Monday, beginning with a huge Italy v. Spain match that could go either way, followed by England v. Iceland, which isn't likely to be as close.
While a few key Americans are still away for Copa America, there are plenty of viable fantasy options for Saturday's eight-game MLS slate.
The Copa America Centenario finishes this weekend, highlighted by a final rematch between Argentina and Chile.
The knockout rounds begin Saturday, with Cristiano Ronaldo, Gareth Bale and Robert Lewandowski highlighting the upper-tier options.
Schuyler Redpath and JD Bazzo break down MLS' three-game Wednesday slate, which includes a very intriguing RSL vs. Red Bulls match that could produce plenty of fantasy points.
The final group stage matches will be played Wednesday, which could be the last time we see Zlatan Ibrahimovic playing for Sweden.
There are plenty of upper-tier options available on the two-game, two-day slate for the Copa America semifinal matches, with Lionel Messi leading the way against the U.S.
Groups C and D finish up Tuesday, with Germany and Spain well positioned to take the top spots, but some potential squad rotation could open up fantasy rosters.
Group B finishes up Monday, with three teams in reach of finishing on top of the table before heading to the knockout rounds.
The final matches of Group A will be played at the same time Sunday, with France needing only a draw to finish first.
Copa America and Euros may still be going on, but Major League Soccer is back in action with a heavy Saturday slate.
The United States already clinched their spot in the semifinal, while six teams will compete for the last three spots over the next two days.
When Portugal are on the slate, the simple question is: do we fade Cristiano Ronaldo?