Zlatan Ibrahimovic's arrival in MLS will dominate the attention Saturday, but Nemanja Nikolic has a great opportunity for a breakout game at home against Portland.
Toronto FC are still looking for their first goal of the 2018 MLS season, and they'll look toward Sebastian Giovinco to break through Friday against Real Salt Lake.
With Sergio Aguero potentially sidelined with injury, a few other Man City attackers will have to step up Saturday at Everton.
Alexis Sanchez and Romelu Lukaku will get most of the attention for fantasy players looking for exposure to Manchester United, but don't forget about Marcus Rashford if he starts.
With Sergio Aguero unlikely to start Saturday at Everton, more of the scoring load for Manchester City could fall to Raheem Sterling.
Manchester United's expected dominance of Swansea City on Saturday is likely to cause plenty of fantasy players to focus on attackers like Romelu Lukaku, Alexis Sanchez and Paul Pogba.
Fantasy players are likely to to give long looks at Romelu Lukaku as Manchester United host Swansea City on Saturday, but he may not be the best option for cash games.
Cardiff are big favorites and have the highest implied goal total as they host Burton Albion as part of Friday's six-match slate.
Manchester United will host Swansea City at Old Trafford on Saturday, which means plenty of fantasy players could be stacking the Red Devils.
Andrew Laird and Jordan Cooper preview Saturday's daily fantasy Premier League slate, which includes both Manchester clubs as decent favorites even though one is playing away.
The Red Bulls are the biggest favorites on Saturday's late four-game slate, and the oddsmakers are giving Bradley Wright-Phillips the best odds at scoring at least one goal.
The Timbers have a tough matchup at Dallas on Saturday, which could make the decision whether to pay up for Diego Valeri a little easier.
The Sounders will be without some key contributors, namely Nicolas Lodeiro, at Dallas on Sunday, which could open up some value plays but are they worth trusting?
Cristiano Ronaldo is expected to have a big game at home against Girona on Sunday, but will fantasy players miss out on other elite scorers if they pay up for the Real Madrid star?
Sunday's two-game FA Cup slate isn't expected to have a ton of goals, so fantasy players may have to rely on Willian for a lot of their points.
Saturday's five-game slate is packed with solid fantasy producers, and most of the games are expected to be close, with Monterrey the only solid favorite.
Juventus are heavily favored away to SPAL on Saturday, and the bookmakers are giving Gonzalo Higuain a good chance to find the back of the net.
Atlanta United have a promising matchup at home against Vancouver on Saturday, which could mean good things for Miguel Almiron.