Tottenham suffered a crushing loss to Juventus in the Champions League on Wednesday, but they'll look to bounce back against Bournemouth at the Vitality Stadium.
Tigres and Club America are both home favorites on Saturday's two-game slate, but there could still be plenty of fantasy points to be had among all four teams.
Lionel Messi is unavailable for Saturday's match against Malaga, which means fantasy players won't necessarily have their guaranteed goal.
The Red Bulls may not have the highest win odds on Saturday's four-game late slate, but no one has better anytime goal scoring odds than Bradley Wright-Phillips.
Alvaro Morata's spot in the starting XI isn't guaranteed, but he could be a huge reward for fantasy managers willing to risk it.
Real Salt Lake will host expansion-side LAFC on Saturday, likely pushing plenty of fantasy players toward Albert Rusnak.
With few forwards to pay up for, Chelsea midfielder Eden Hazard could be the highest-owned player on Saturday's six-game slate.
Chelsea are big favorites at home to Crystal Palace on Saturday, and with few elite goal scorers to pay up for, many fantasy players will be stacking the Chelsea defense.
Morelia are the big favorites on Friday's two-game slate, as the bookmakers expect them to easily handle 14th-place Veracruz.
Chelsea's attackers have been a bit inconsistent this season, but Willian may be too hard to pass up at home against Crystal Palace.
Radamel Falcao has been sidelined for the past month with a thigh injury, but he is expected to return Friday to face Strasbourg and comes in with the best anytime goal scorer odds on DraftKings' three-game slate.
Andrew Laird and Jordan Cooper review this week's Champions League action before previewing Saturday's six-game daily fantasy Premier League slate, which only includes one top-six team and a ton of recognizable set-piece takers.
Chelsea are the only top-six club on Saturday's six-game slate, and they're high win odds and implied goal total will help Eden Hazard be a popular fantasy option.
Marseille have a number of solid fantasy options, and they'll all be tested in a home match against Athletic Club on Thursday.
Atletico Madrid are the biggest favorites and have the highest implied goal total on Thursday's early Europa League slate, which means many eyes will be on Antoine Griezmann.
A win Wednesday would book Tottenham's ticket to the quarterfinal, and they'll be relying on Harry Kane to try and get them there.
Fantasy players are likely to be keying on Harry Kane and Gabriel Jesus for their two forward spots, but Evan Morter says those looking for a differential should turn to Paulo Dybala.
Tottenham have the advantage over Juventus after scoring two goals in Turin in the first leg, but that doesn't mean Christian Eriksen will be sitting back in Wednesday's deciding match.