Paris Saint-Germain continue to be without Neymar and will miss Edinson Cavani on Saturday, which means Kylian Mbappe will need to step up against Rennes.
Ignacio Piatti failed to do much during the Impact's midweek match at Chicago, but he has a great opportunity to bounce back Saturday at home against the Union.
Chelsea need a win at St. James' Park and help from Brighton to secure Champions League football for next season, which means they'll need a big performance from Eden Hazard.
Another season in the Champions League is in reach for Liverpool, and they'll likely rely on Mohamed Salah to get them there.
Houston travel to Vancouver to take on the Whitecaps on Friday night, and the Dynamo will look for Alberth Elis to make an impact.
Andrew Laird and Jordan Cooper preview Sunday's 10-game daily fantasy Premier League slate, the last one of the 2017/18 season.
Marseille are expected to handle Guingamp on Friday, with Florian Thauvin coming in with the best anytime goal scoring odds.
Liverpool can solidify their top-four spot with at least a draw Sunday against Brighton, and no player on the 10-game slate has higher anytime goal scorer odds than Mohamed Salah.
Manchester United have nothing to play for Wednesday against West Ham, but with World Cup spots up for grabs, Anthony Martial could shine.
Atlanta United host Sporting KC on Wednesday night, and no one on the five-game slate has better goal-scoring odds than Josef Martinez.
Harry Kane was held off the scoresheet by West Brom last weekend, but Spurs will need him to step up as they try to grab three points at home to Newcastle on Wednesday.
Swansea City and Southampton will battle in a huge relegation six-pointer Tuesday, with the Swans needing Jordan Ayew to step up if they want a shot at three points.
Manchester City are expected to destroy Huddersfield on Sunday, which means plenty of fantasy players will be turning their eyes toward Raheem Sterling.
Saturday's slate is highlighted by the first Hudson River Derby of the season, and the Red Bulls will need a big performance from Bradley Wright-Phillips if they want all three points.
Christian Eriksen's price is high for Saturday's slate, but Evan Morter explains why he's worth the investment against West Brom.
Tottenham are big favorites away to West Brom, which could put Kieran Trippier and other Spurs players on a lot of fantasy rosters.
Harry Kane and Christian Eriksen figure to be highly owned in cash games and GPPs on Saturday, but fantasy players will need to find some value plays if they want to roster both Tottenham stars.
Stoke City are desperate for three points Saturday at home to Crystal Palace, and Xherdan Shaqiri will have to step up if they're to grab them.