Tigres and Monterrey are the favorites on Sunday's two-game slate, which means Andre-Pierre Gignac could be a popular option.
With Romain Alessandrini suspended due to yellow card accumulation, the Galaxy will need to rely even more on Zlatan Ibrahimovic in their attack.
The Galaxy are big favorites at home against Orlando City on Sunday, and fantasy players are likely to give a long, hard look toward Zlatan Ibrahimovic.
Houston could have a tough time against the Timbers in Portland on Saturday, but they always have a chance with the dangerous Alberth Elis in their attack.
Club America are big favorites at home to Atlas on Saturday, while the Chivas-Cruz Azul match expected to be very close.
Diego Valeri has been churning out the fantasy points this season, and RotoWire'e Schuyler Redpath thinks he'll keep it going Saturday against Houston.
Toronto FC is the big favorite on Saturday's slate, with the oddsmakers naturally expecting Sebastian Giovinco to have a big impact.
Both away teams are favored on Friday's two-game Liga MX slate, but that doesn't mean fantasy players should be avoiding hosts Morelia and Puebla.
David Villa could return from injury Thursday, and the oddsmakers are expecting him to have a big impact on the road at Orlando City.
The Red Bulls are favored away to D.C. United on Wednesday, which is likely to get plenty of people looking to Bradley Wright-Phillips for at least one goal.
Los Angeles FC is favored away to Minnesota United on Sunday, and fantasy players will have to decide if Carlos Vela is worth his very high price.
The Red Bulls are big favorites at home to the Revolution on Saturday, and the oddsmakers think Bradley Wright-Phillips has a great chance to find the back of the net.
The new Liga MX season kicks off Friday, with Veracruz and Atlas both expected to win while hosting Pumas and Queretaro, respectively.
The Revolution are road underdogs to Minnesota United on Wednesday, but Diego Fagundez can still make a meaningful fantasy impact.
Atlanta United welcomes the Sounders to Mercedes-Benz Stadium on Sunday, and the oddsmakers are expecting a big performance from Josef Martinez.
The Red Bulls are decent favorites at home against Sporting KC on Saturday, with Bradley Wright-Phillips coming in with solid anytime goal scorer odds.
Antoine Griezmann leads France into the World Cup final against Croatia on Sunday, but can fantasy players rely on him to produce? RotoWire's Andrew Laird dives in to find out.
The decision on which French attackers to roster will be a tough one this weekend, but Adam Zdroik continues to side with Antoine Griezmann over Kylian Mbappe.