The Red Bulls will take on a resurgent D.C. United on Sunday, and they'll likely rely on Bradley Wright-Phillips to lead the charge.
First-place Cruz Azul visits third-place Santos Laguna on Sunday, but fantasy players may be better off focusing on Toluca at home against Leon.
Toronto is the second-biggest favorite on Saturday's five-game MLS slate, which means fantasy players will surely be targeting Sebastian Giovinco.
Eden Hazard is apparently not ready to play a full 90 minutes yet, but fantasy players could be tempted to roster him anyway if he starts Sunday at Newcastle.
Josef Martinez has already tied the MLS single-season goal-scoring record, and he'll look to take control of it in Orlando on Friday.
A home match against Brighton is likely to see plenty of people trying to stack Liverpool this weekend, according to RotoWire's Schuyler Redpath.
Lyon are big favorites at home to Strasbroug on Friday, and Memphis Depay could be a very popular fantasy option.
There are likely to be plenty of Liverpool stacks on Saturday's six-game slate, but RotoWire's Chris Owen explains why fantasy players shouldn't forget about Manchester City.
Mohamed Salah figures to be a very popular play on Saturday's five-game slate, and while fantasy players could pivot to Sadio Mane, RotoWire's Andrew Laird explains why Roberto Firmino may be the better alternative.
Mohamed Salah and Sadio Mane are attractive plays for Saturday's five-game slate, and RotoWire's Adam Zdroik dives in to explain why one makes more sense than the other.
Andrew Laird and Jordan Cooper preview Saturday's five-game daily fantasy Premier League slate, with the biggest lineup decision coming down to whether or not playing Mohamed Salah is optimal in cash games.
Liverpool are expected to win big against Brighton on Saturday, with fantasy players likely having to decide whether it's worth paying up for Mohamed Salah and/or Sadio Mane.
The Dynamo are favored at home in Thursday's rivalry game against FC Dallas, and they'll need Alberth Elis to step up as he returns from a two-match ban.
Tigres are the biggest favorites on Wednesday's five-game slate, so fantasy players will have to decide if they want to pay up for Andre-Pierre Gignac.
Things always get heated during the Hudson River Derby, and New York City FC will need a big game from Maximiliano Moralez if they want to grab all three points.
Gabriel Jesus was one of three Manchester City players with at least 13.00 floor points on DraftKings last weekend, an impressive total given that none took a set piece.
Ajax are strong favorites at home to Dynamo Kyiv on Wednesday, which will put Hakim Ziyech under the fantasy spotlight.
PSV Eindhoven are favored away to BATE Borisov on Tuesday, but is it enough to make fantasy players pay up for Hirving Lozano?