With Diego Valeri possibly sitting out due to injury, Darlington Nagbe could take on a bigger attacking role for the Timbers on Monday against the Rapids.
Sunday's action is highlighted by the Hudson River Derby, which ended in a 7-0 Red Bulls win at Yankee Stadium earlier this season.
Saturday's three-game MLS slate includes plenty of fireworks, with Toronto FC's Sebastian Giovinco leading the charge.
Iceland's surprising run to the quarterfinal has them matched up with the home nation on Sunday, but Saturday features a heavyweight battle between Italy and Germany.
Andrew Laird and JD Bazzo break down the upcoming weekend of MLS matches, which includes a number of two and three-game slates on most DFS sites.
Only two teams will play twice in Round 16, but Andrew Laird explains why focusing on players from those teams comes with some complications for further weeks.
Andrew Laird and Mike Gottlieb discuss a few of the completed transfers this summer, as well as a number that could (but likely won't) happen.
The MLS schedule will be a bit staggered for the July 4 weekend, with only two games kicking off the Friday DFS slate.
Cristiano Ronaldo highlights the players available for the two opening quarterfinal matches, but there are a few other stars who could outproduce him.
The Round of 16 concludes Monday, beginning with a huge Italy v. Spain match that could go either way, followed by England v. Iceland, which isn't likely to be as close.
While a few key Americans are still away for Copa America, there are plenty of viable fantasy options for Saturday's eight-game MLS slate.
The Copa America Centenario finishes this weekend, highlighted by a final rematch between Argentina and Chile.
The knockout rounds begin Saturday, with Cristiano Ronaldo, Gareth Bale and Robert Lewandowski highlighting the upper-tier options.
Major League Soccer's Round 15 includes four teams with two matches, and RotoWire MLS expert Schuyler Redpath breaks down his top targets.
Schuyler Redpath and JD Bazzo break down MLS' three-game Wednesday slate, which includes a very intriguing RSL vs. Red Bulls match that could produce plenty of fantasy points.
The final group stage matches will be played Wednesday, which could be the last time we see Zlatan Ibrahimovic playing for Sweden.
There are plenty of upper-tier options available on the two-game, two-day slate for the Copa America semifinal matches, with Lionel Messi leading the way against the U.S.
Groups C and D finish up Tuesday, with Germany and Spain well positioned to take the top spots, but some potential squad rotation could open up fantasy rosters.