Houston could have a tough time against the Timbers in Portland on Saturday, but they always have a chance with the dangerous Alberth Elis in their attack.
Club America are big favorites at home to Atlas on Saturday, while the Chivas-Cruz Azul match expected to be very close.
Diego Valeri has been churning out the fantasy points this season, and RotoWire'e Schuyler Redpath thinks he'll keep it going Saturday against Houston.
Toronto FC is the big favorite on Saturday's slate, with the oddsmakers naturally expecting Sebastian Giovinco to have a big impact.
Both away teams are favored on Friday's two-game Liga MX slate, but that doesn't mean fantasy players should be avoiding hosts Morelia and Puebla.
David Villa could return from injury Thursday, and the oddsmakers are expecting him to have a big impact on the road at Orlando City.
The Red Bulls are favored away to D.C. United on Wednesday, which is likely to get plenty of people looking to Bradley Wright-Phillips for at least one goal.
D.C. United will play two games this week, and while some people may consider giving the captain's armband to Wayne Rooney, RotoWire's Adam Zdroik thinks Yamil Asad is the much better option.
New York City FC will play two games in Week 22, but that isn't quite enough to make Maximiliano Moralez the top midfielder in JD Bazzo's weekly positional rankings.
Andrew Laird, Schuyler Redpath and JD Bazzo preview the final week of the spring MLS fantasy season, one that includes eight teams playing twice.
Predicting saves and clean sheets isn't the easiest part of building a fantasy Premier League team, but that doesn't stop RotoWire's Andrew Laird from trying.
Los Angeles FC is favored away to Minnesota United on Sunday, and fantasy players will have to decide if Carlos Vela is worth his very high price.
The Red Bulls are big favorites at home to the Revolution on Saturday, and the oddsmakers think Bradley Wright-Phillips has a great chance to find the back of the net.
Mike Gottlieb and Andrew Laird begin their preview of the upcoming fantasy Premier League season, including whether Mohamed Salah is a must-own, which promoted players will be worthy fantasy producers and what to do with all the available Manchester City
The new Liga MX season kicks off Friday, with Veracruz and Atlas both expected to win while hosting Pumas and Queretaro, respectively.
The Revolution are road underdogs to Minnesota United on Wednesday, but Diego Fagundez can still make a meaningful fantasy impact.
Schuyler Redpath and Adam Zdroik preview Week 21 of the MLS Fantasy season, one that includes some double gameweeks but lots of teams playing once with extremely favorable matchups.
Two teams will play twice in the final week of the FMLS spring season, but could fantasy players still give the armband to Josef Martinez despite having just one game?
