The Buccaneers need to get the ball to Mike Evans, and it's not obvious what the Giants defense can do to stop it.
The Ravens might want to shadow George Pickens with Marlon Humphrey, because the other Ravens corners can't cover Pickens.
Justin Jefferson will almost certainly have a big game Sunday, and the Colts pass defense is weak enough for Jordan Addison to get rolling in the same game.
Kyle Pitts' production is surging despite a decline in playing time, making him one of the riskiest assets in the fantasy landscape.
With Tua Tagovailoa back in the lineup Jaylen Waddle should get rolling against Arizona, and the same is true of Tyreek Hill if he plays through his foot injury.
Jerry Donabedian has the Week 6 injury scoop following Friday injury reports, including a big opportunity for Bucs RB Bucky Irving with teammate Rachaad White listed as doubtful.
The showdown between Detroit and Dallas could set up a punch-for-punch heavyweight contest where CeeDee Lamb and Amon-Ra St. Brown both go off.
Where does Marvin Harrison Jr. rank after last week's two-catch game?
Michael Pittman got back on track in Week 4 and should keep it rolling in Week 5, as neither the Jags nor Colts have viable coverage personnel.
George Pickens should get going against an Indianapolis defense with questionable boundary personnel
If Patrick Surtain shadows Mike Evans on the boundary then it could create a target funnel to Chris Godwin in the slot.
Jim Coventry provides a few of his favorite plays for Locker's Picks contests in Week 3, including Aaron Jones of the Vikings.
Amon-Ra St. Brown will likely torch a thin Buccaneers secondary playing without its star enforcer in Antoine Winfield.
Mike Evans has to slow down eventually, but probably not against Washington's undersized boundary corners.
Nico Collins could see an enormous target share with the Texans managing multiple wideout injuries.
DK Metcalf could pose a major big-play threat to Tennessee's injury-challenged corner rotation.
If New England prioritizes defending Travis Kelce then the Pats might not have leftover personnel to cover Rashee Rice.
Ja'Marr Chase should keep rolling against a Colts secondary with poor boundary corner personnel.