Brandon Aiyuk headshot

Brandon Aiyuk Injury: Unlikely to have practice window opened this week

Written by RotoWire Staff

Updated on October 29, 2025 at 9:30am

Coach Kyle Shanahan said Monday that the 49ers don't intend to designate Aiyuk (knee) to return from the reserve/PUP list Wednesday, Matt Barrows of The Athletic reports.

On Friday, Shanahan told David Lombardi of SFStandard.com that Aiyuk's 21-day practice window may open this week, but even if it doesn't, the 49ers currently are in "week-to-week mode" with the wide receiver. Aiyuk is a little over one year removed from suffering ACL and MCL tears in his right knee during Week 7 of the 2024 campaign, so he's likely facing a significant ramp-up process even when he is cleared to practice.

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