Real Madrid are heavy favorites against Huesca, and there's plenty of optimism that Karim Benzema will have a big impact.
Liverpool have a tough matchup against Tottenham on Sunday, but Sadio Mane has shown time and again that he can have an impact against anyone.
Atletico Madrid continue to fight for the top of La Liga, and they'll need a solid performance from Antoine Griezmann on Saturday against Alaves.
Manchester City is expected to throttle Fulham on Saturday, with plenty of reason to think Sergio Aguero will play a big part.
Manchester United should get plenty of interest from fantasy players on Saturday's slate, with Marcus Rashford primed to make an impact.
Chelsea are heavily favored against Cardiff on Sunday, which should push plenty of fantasy players to stack the Blues instead of targeting the Liverpool v. Tottenham match.
Lyon will look to avenge their previous loss to Rennes, and they'll need Nabil Fekir to step up if they want to have a chance.
Hoffenheim take on Bayer Leverkusen in a match with significant top-six implications, with the home side likely needing an impact from Joelinton.
Andrew Laird and Schuyler Redpath preview Saturday's five-game MLS slate on DraftKings, including whether fantasy players can trust expansion side FC Cincinnati at home against the Philadelphia Union.
Crystal Palace are the second-biggest favorite on Saturday's six-game slate, and while he has no role on set pieces anymore, Andros Towsend could be a popular cash-game play.
Andrew Laird and Jordan Cooper preview Saturday's six-game daily fantasy Premier League slate on DraftKings, including whether it's necessary to load up on Manchester United, who are the biggest favorite at hom
Manchester United's home match against Watford is likely to get plenty of attention, and RotoWire's Adam Zdroik puts Marcus Rashford and Paul Pogba under the spotlight.
Portugal disappointed in their Euro 2020 qualification opener last week, and they'll have a tough task bouncing back against Serbia.
Kylian Mbappe has been unstoppable this season, and there's little reason to think Iceland will be able to shut him down in their Euro 2020 qualifier.
Germany are in a bit of transition as they open their Euro 2020 qualification campaign against the Netherlands, but they'll likely continue to rely on Marco Reus to make an impact.
Wales will be without Aaron Ramsey for their Euro 2020 qualifier against Slovakia, putting more pressure on the shoulders of Gareth Bale.
Sweden host Romania in their first Euro 2020 qualifying match Saturday, and they will need Emil Forsberg to step up.
Spain are heavily favored at home against Norway in their opening Euro 2020 qualifier, with La Roja expecting another solid performance from Sergio Ramos.