The Round of 16 concludes Monday, beginning with a huge Italy v. Spain match that could go either way, followed by England v. Iceland, which isn't likely to be as close.
While a few key Americans are still away for Copa America, there are plenty of viable fantasy options for Saturday's eight-game MLS slate.
The Copa America Centenario finishes this weekend, highlighted by a final rematch between Argentina and Chile.
The knockout rounds begin Saturday, with Cristiano Ronaldo, Gareth Bale and Robert Lewandowski highlighting the upper-tier options.
Schuyler Redpath and JD Bazzo break down MLS' three-game Wednesday slate, which includes a very intriguing RSL vs. Red Bulls match that could produce plenty of fantasy points.
The final group stage matches will be played Wednesday, which could be the last time we see Zlatan Ibrahimovic playing for Sweden.
There are plenty of upper-tier options available on the two-game, two-day slate for the Copa America semifinal matches, with Lionel Messi leading the way against the U.S.
Groups C and D finish up Tuesday, with Germany and Spain well positioned to take the top spots, but some potential squad rotation could open up fantasy rosters.
Group B finishes up Monday, with three teams in reach of finishing on top of the table before heading to the knockout rounds.
The final matches of Group A will be played at the same time Sunday, with France needing only a draw to finish first.
Copa America and Euros may still be going on, but Major League Soccer is back in action with a heavy Saturday slate.
The United States already clinched their spot in the semifinal, while six teams will compete for the last three spots over the next two days.
When Portugal are on the slate, the simple question is: do we fade Cristiano Ronaldo?
Zlatan Ibrahimovic is back in action Friday, but is he worth taking against the very strong Italy defense?
Copa America heads to the quarterfinal round, with DraftKings breaking out an always difficult two-game, two-day slate.
Two huge grudge matches highlight Thursday's three-game slate, though the other game of the day could produce the most fantasy points.
The host nation returns to action for Wednesday's three-game slate, with many fantasy owners likely flocking toward France's Dimitri Payet after his stunning opening game.
Cristiano Ronaldo highlights Tuesday's Euro action, but fantasy owners will need to find some other pieces to fit together with the Portuguese superstar.